Degradable organic and inorganic composite nano-particle capable of realizing anti-tumor treatment, and preparation method thereof

Abstract

The invention discloses a degradable organic and inorganic composite nano-particle capable of realizing anti-tumor treatment, and a preparation method thereof. The inner part of the particle is Fe3O4,the middle layer of the particle is gamma-PGA (polyglycolic acid) and Poly-l-arginine (PA), and the outer layer is a golden shell. The size of the particle is about 200nm, and the particle has biodegradability. The preparation method for the degradable organic and inorganic composite nano-particle comprises the following steps: through a gamma-PGA, Fe<2+> and Fe<3+> coprecipitation method, preparing high-dispersion magnetic Fe3O4 nano-particles; then, through a static electricity mutual function, adsorbing doxorubicin hydrochloride (DOX.HCl) and PA to the surface of the particle; finally, carrying out in-situ reduction of chloroauric acid on the surface of the PA to prepare the gamma-PGA-Fe3O4-DOX-PA@Au(PFDR-Au) composite nano-particles. The method has the advantages of simpleness in operation, short time consumption, small material consumption, no organic solvent, moderate and controllable synthesis condition and high reproducibility. The nano-particle has biodegradability and good biocompatibility, Adriamycin can be released under the condition of photo-thermal stimulation and micro acid, and a tumor growth inhibition effect is obvious.

Description

technical field [0001] The invention belongs to the field of nanomaterials and their preparation, and in particular relates to degradable organic-inorganic composite nanoparticles and a preparation method thereof. Background technique [0002] Compared with organic nanomaterials, inorganic nanomaterials are more stable chemically and mechanically, but the retention of inorganic nanomaterials in vivo has attracted widespread attention of many researchers. It has been found that inorganic nanomaterials can exist in the body for more than 2 years, which may bring some unpredictable risks. If nanoparticles cannot be biodegraded, long-term accumulation may cause irreversible damage to the body, such as severe oxidative stress, impairment of phagocytic activity of mononuclear phagocytes, etc. Biodegradable materials can be degraded into smaller-sized nanoparticles after performing their functions in the body, and then excreted through metabolism, reducing the potential damage of ...

AI Technical Summary

Problems solved by technology

The synthesis method of the above materials is relatively complicated, and requires high temperature and high pressure. The synthesis process uses toxic organic solvents, and the requirements for the material preparation conditions are relatively strict; secondly, the material itself has poor stability, poor biocompatibility, poor degradability in vivo, and long metabolic cycle. , so it is particularly important to prepare a degradable organic-inorganic composite nanomaterial that is not only biodegradable but also meets the requirements of photothermal therapy through a simple and green method.

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