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A dual-functional imaging-guided photothermal diagnosis and treatment integrated nanoparticle and its preparation method

An imaging-guided, nanoparticle technology, applied in nanotechnology for sensing, general/multifunctional contrast agents, medical preparations containing active ingredients, etc. Comprehensive information and other issues to achieve low biological toxicity, high potential application value, and good photothermal effect

Active Publication Date: 2020-10-30
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low penetration of X-rays, a single CT imaging nanomaterial often cannot obtain comprehensive information on the lesion site

Method used

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  • A dual-functional imaging-guided photothermal diagnosis and treatment integrated nanoparticle and its preparation method
  • A dual-functional imaging-guided photothermal diagnosis and treatment integrated nanoparticle and its preparation method
  • A dual-functional imaging-guided photothermal diagnosis and treatment integrated nanoparticle and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An integrated photothermal diagnosis and treatment nanoparticle guided by dual-function imaging, which is prepared by the following method:

[0031] S1. Weigh 0.379g of lead acetate and 0.468g of mercaptoethanol and dissolve them in 10ml and 20ml of deionized water respectively, and put them in a 100mL flask 2 Mix and stir under atmosphere for 10 min. Adjust the temperature of the water bath to maintain it at 50°C, then slowly add 10 mL of an aqueous solution in which 0.12 g of sodium sulfide is dissolved, and continue the reaction for 15 min after the drop is complete. The product was then cooled to room temperature, and 1.14 g of 3-chloropropionic acid was added thereto, and stirring was continued for 12 h. Purified by dialysis and freeze-dried to obtain lead sulfide nanoparticles (characterized as having a particle size of 10-50nm).

[0032] S2. Weigh 1.15g of acrylic acid and disperse it in 30ml of ethanol. When the temperature reaches 60°C, adjust the pH to 7.5 w...

Embodiment 2

[0035] An integrated photothermal diagnosis and treatment nanoparticle guided by dual-function imaging, which is prepared by the following method:

[0036] S1. Weigh 0.19g of lead acetate and 0.23g of mercaptoethanol and dissolve them in 10ml and 20ml of deionized water respectively, and put them in a 100mL flask 2 Mix and stir under atmosphere for 10 min. Adjust the temperature of the water bath to maintain it at 55°C, then slowly add 10 mL of an aqueous solution in which 0.06 g of sodium sulfide is dissolved, and continue the reaction for 20 min after the drop is complete. The product was then cooled to room temperature, and 0.57 g of 3-chloropropionic acid was added thereto, and stirring was continued for 12 h. Purified by dialysis and freeze-dried to obtain lead sulfide nanoparticles.

[0037] S2. Weigh 1.35g of acrylic acid and disperse it in 30ml of ethanol. When the temperature reaches 55°C, adjust the pH to 8.0 with ammonia water. Slowly add 20ml of ethanol solution...

Embodiment 3

[0040] An integrated photothermal diagnosis and treatment nanoparticle guided by dual-function imaging, which is prepared by the following method:

[0041] S1. Weigh 0.76g of lead acetate and 0.93g of mercaptoethanol and dissolve them in 10ml and 20ml of deionized water respectively, and put them in a 100mL flask 2 Mix and stir under atmosphere for 10 min. Adjust the temperature of the water bath to maintain it at 50°C, then slowly add 10 mL of an aqueous solution in which 0.24 g of sodium sulfide is dissolved, and continue the reaction for 15 min after the drop is complete. The product was then cooled to room temperature, and 2.28 g of 3-chloropropionic acid was added thereto, and stirring was continued for 12 h. Purified by dialysis and freeze-dried to obtain lead sulfide nanoparticles.

[0042] S2. Weigh 1.55g of acrylic acid and disperse it in 30ml of ethanol. When the temperature reaches 60°C, adjust the pH to 7.5 with ammonia water. Slowly add 20ml of ethanol solution...

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Abstract

The invention relates to bifunctional imaging guided photo-thermal diagnosis and treatment integral nanoparticles and a preparation method thereof. The preparation method comprises the following steps: S1, lead sulfide nanoparticles are prepared by taking lead acetate, sodium sulfide, mercaptoethanol and 3-chloropropionic acid as raw materials, and water as a solvent; S2, a gadolinium-containing complex is prepared by taking acrylic acid, phenanthroline hexahydrate gadolinium chloride as monomers, and ethanol as a solvent; S3, the lead sulfide nanoparticles and the gadolinium-containing complex are put into polyethyleneglycol methacrylate, further a catalyst and an activating agent are added, and the components are enabled to react, so as to obtain gadolinium complex and polyethyleneglycolmethacrylate grafted nanoparticles. The nanoparticles have the beneficial effects that a gadolinium complex is grafted with the surfaces of the lead sulfide nanoparticles for a first time, the obtained nanoparticles have CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) imaging guide functions and meanwhile are good in photo-thermal effect; the nanoparticles are relatively long in blood half-life period and low in biotoxicity, thereby having relatively high potential application values in clinical diagnosis.

Description

technical field [0001] The invention belongs to the field of material science and biomedicine, and specifically relates to a dual-function imaging-guided photothermal diagnosis and treatment integrated nanoparticle and a preparation method thereof. Background technique [0002] Photothermal diagnosis and treatment refers to the absorption of special light by nanomaterials, which presents excellent multifunctional nanomaterials with good diagnostic and therapeutic effects on lesions. Compared with the early photothermal diagnostic reagents, lead sulfide-based photothermal diagnostic reagents have excellent computed tomography (CT) imaging and photothermal therapy (PTT) performance, and have good applications in the diagnosis and treatment of living tumors. potential. As a high atomic number material, lead sulfide has the advantages of excellent X-ray absorption capacity, ultra-small particle size, and good light-to-heat conversion. The CT imaging performance of lead sulfide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K41/00A61K49/10A61K49/12A61K49/18A61K49/00A61P35/00B82Y5/00B82Y15/00
CPCA61K41/0052A61K49/0002A61K49/049A61K49/101A61K49/126A61K49/1833A61K49/1857B82Y5/00B82Y15/00
Inventor 徐祖顺邹义彪张墨珏杨盛力
Owner HUBEI UNIV
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