A method for separating valine from valine fermentation broth
A technology of valine and fermentation broth, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the constraints of large-scale production of valine industry, large consumption of chromatographic fillers, large amount of solvents, etc. problems, to achieve the effect of ensuring separation efficiency and service life, reducing equipment investment and production loss, and low operating costs
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Embodiment 1
[0034] refer to Figure 1~2 , a method for separating valine from valine fermentation broth, comprising the steps of:
[0035] (1) Add 100 parts by weight of macroporous styrene-divinylbenzene polymer, 50 parts by weight of paraformaldehyde, 200 parts by weight of anhydrous zinc chloride, 200 parts by weight of vitriol oil and 400 parts by weight of ice in the reactor Acetic acid, feed hydrogen chloride gas while stirring, and react for 12 hours; after the reaction, wash with deionized water to neutrality, wash with ethanol and acetone, and dry in vacuum for 24 hours to obtain chloromethylated polystyrene resin (CMCPS);
[0036] (2) Take 50 parts by weight of CMCPS obtained in step (1) in the reactor, add 100 parts by weight of glycidyl methacrylate, 1.5 parts by weight of cuprous bromide, 5 parts by weight of 2,2'-bipyridine and 20 parts by weight N,N-Dimethylamide density, first sealed with nitrogen, then evacuated, 70 ° C for 16 hours; Washing, vacuum drying for 24h, to o...
Embodiment 2
[0042] refer to Figure 1~2 , a method for separating valine from valine fermentation broth, comprising the steps of:
[0043] (1) Add 150 parts by weight of macroporous styrene-divinylbenzene polymer, 100 parts by weight of paraformaldehyde, 250 parts by weight of anhydrous zinc chloride, 300 parts by weight of vitriol oil and 550 parts by weight of ice in the reactor Acetic acid, while stirring hydrogen chloride gas. React for 12 hours; after the reaction, wash with deionized water to neutrality, wash with ethanol and acetone, and dry in vacuum for 24 hours to obtain chloromethylated polystyrene resin (CMCPS);
[0044] (2) Take 80 parts by weight of CMCPS in step (1) in the reactor, add 150 parts by weight of glycidyl methacrylate, 3 parts by weight of cuprous bromide, 10 parts by weight of 2,2'-bipyridine and 25 parts by weight N,N-Dimethylamide density, first sealed with nitrogen, then evacuated, and reacted at 70°C for 16h; Washing, vacuum drying for 24h, to obtain the...
Embodiment 3
[0050] refer to Figure 1~2 , a method for separating valine from valine fermentation broth, comprising the steps of:
[0051] (1) Add 200 parts by weight of macroporous styrene-divinylbenzene polymer, 150 parts by weight of paraformaldehyde, 300 parts by weight of anhydrous zinc chloride, 400 parts by weight of vitriol oil and 70 parts by weight of ice in the reactor Acetic acid, while stirring hydrogen chloride gas. React for 12 hours; after the reaction, wash with deionized water to neutrality, wash with ethanol and acetone, and dry in vacuum for 24 hours to obtain chloromethylated polystyrene resin (CMCPS);
[0052] (2) Get 100 parts by weight of CMCPS in step (1) in the reactor, add 200 parts by weight of glycidyl methacrylate, 5 parts by weight of cuprous bromide, 15 parts by weight of 2,2'-bipyridyl and 30 parts by weight Parts by weight of N,N-dimethylamide dense, first sealed and ventilated with nitrogen, then vacuumized, and reacted at 70°C for 16h; Acetone washin...
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