Preparation method of release-controllable electrospun fiber drug carrier with nested nanostructure

A nanostructure and electrospun fiber technology, which is applied in fiber treatment, plant fiber, pharmaceutical formulations, etc., can solve the problems of short drug release time and achieve stable and sufficient drug release.

Active Publication Date: 2018-05-15
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some scholars have prepared it into nanoparticles and applied it in the field of drug delivery. However, due to its fast degradation rate, there is a certain burst release phenomenon, and the short drug release time limits its application in the field of drug delivery. How to simply and efficiently It is also a problem to prepare lignin nanoparticles with uniform particle size and controllable size

Method used

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  • Preparation method of release-controllable electrospun fiber drug carrier with nested nanostructure
  • Preparation method of release-controllable electrospun fiber drug carrier with nested nanostructure
  • Preparation method of release-controllable electrospun fiber drug carrier with nested nanostructure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Dissolve kraft lignin and paclitaxel in tetrahydrofuran at a mass ratio of 10:1 to prepare an organic solution with a kraft lignin concentration of 10 mg / ml. Pass the obtained organic solution through a 0.22 μm filter membrane to remove Insoluble matter; the filtrate is slowly added to the ultrapure water under stirring, the stirring speed is 300r / min, the volume ratio of water and lignin solution is 4:1, stirred for 10min, and the liquid is centrifuged at 5000r / min for 10min, and taken The supernatant was put into a 12-14KDa dialysis bag for dialysis for 2 days, and the drug-loaded carrier particles were obtained after freeze-drying. figure 1 It is an electron microscope scanning picture of the obtained carrier particles, and it can be seen that the obtained carrier particles are uniform in size and uniform in shape.

[0026] (2) Use an ultrasonic cell pulverizer to disperse the carrier particles prepared in step (1) evenly in deionized water at a concentration of ...

Embodiment 2-5

[0037] Except for lignin concentration, other process parameters are the same as in Example 1, and the addition ratio of lignin in Examples 2-5 is shown in Table 1

[0038] Table 1 Example 2-5 lignin concentration

[0039]

[0040] The microstructure of the spun fiber membrane obtained in Examples 2-5 is consistent with that of Example 1.

[0041] Embodiment 2-5 drug release and antibacterial experiment see respectively Figure 4 with 5 .

[0042] The comparison shows that with the increase of the drug-loaded lignin nanoparticles, the release rate of the drug gradually increases, but there is no burst release phenomenon in these types; the diameter of the inhibition zone increases with the increase of the drug-loaded lignin content, and the antibacterial effect Increase.

Embodiment 6-8

[0044] Except PVA concentration, other processing parameters are identical with embodiment 1, and embodiment 6-8 PVA concentration content is shown in Table 2

[0045] Table 2 Example 6-8 PVA concentration

[0046]

[0047] The microstructure of the spun fiber membrane prepared in Examples 6-8 is consistent with that of Example 1, and its bacteriostasis, degradation performance, and drug release performance are all good.

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Abstract

The invention relates to a preparation method of a degradable and release-controllable polymer carrier, in particular to a preparation method of a release-controllable electrospun fiber drug carrier with a nested nanostructure. The method comprises the following four steps: preparing carrier particles, preparing electrostatic spinning fluid, preparing a spinning fiber membrane and carrying out aftertreatment on the fiber membrane; the obtained fiber membrane can be both applied to the exterior of a body and implanted into the body, and has good biological activity, biodegradability, antibacterial property and good drug loading property; furthermore, lignin nanoparticles wrapped in spinning fibers show a certain antibacterial property in a degradation process of the fiber membrane; in addition, the fiber membrane prepared by the method can be biodegraded in a long-term service period in the alkaline environment of body fluid, so that the stable release of a drug is ensured, and the drugis enabled to be fully and thoroughly released.

Description

technical field [0001] The invention belongs to the field of biomaterials, and relates to a method for preparing a polymer carrier capable of loading drugs, in particular to a method for preparing a degradable polymer carrier with controllable release. Background technique [0002] Nanotechnology offers new approaches to many biomedical applications, especially the controlled delivery of drugs. The application of drug delivery carrier can improve the treatment efficiency and reduce the toxic and side effects. At present, there have been reports on nanoparticles and hydrogels as drug delivery carriers. Among them, there is a certain burst release phenomenon of individual nanoparticles as a transport carrier, and the drug release time is short, and the degradation of some carrier materials becomes a problem; as a drug carrier, hydrogel requires a certain amount of cross-linking, and the cross-linking process reduces the quality of the material. biocompatibility. [0003] Co...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/42D01D5/00D04H1/728D06M15/15A61K31/12A61K31/337A61K31/575D06M101/06
CPCA61K9/70A61K31/12A61K31/337A61K31/575A61K47/32A61K47/42D01D5/0069D01D5/0092D04H1/728D06M15/15D06M2101/06
Inventor 梁春永雒永超夏丹王洪水刘帅
Owner HEBEI UNIV OF TECH
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