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Polyglycolic acid resin composite material and manufacturing method thereof

A technology of resin composite materials and polyglycolic acid, applied in medical science, prosthesis, surgery, etc., can solve problems such as short degradation time, unfavorable animal or human bone healing, and increased patient pain

Inactive Publication Date: 2018-05-29
陈逊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Through extensive investigation and research at home and abroad, it is known that the incidence of bone defects due to trauma is high in clinical practice. The existing methods have always used metal materials such as stainless steel as internal fixation materials for bone repair, but it has its own obvious disadvantages. Disadvantages: First, because the firmness of the metal material will reduce the stimulation of the physiological stress of the cross-section, forming a functional replacement and stress shielding protection, thereby forming osteoporosis; second, because the metal material cannot be biodegraded and needs to be removed by a second operation after bone healing, Increased the pain of the patient; the third is that the metal fixation material will cause some complications
[0025] In China Patent No.: CN201380047578.6, a polyglycolic acid composition and its manufacturing method are introduced, in which polylactic acid, a biocompatible material, and silicon oxide, silicate, carbonate, sulfate, and clay are used At least one of the group of minerals, inorganic fibrous filling materials and inorganic whisker-like filling materials; since polyglycolic acid and polylactic acid are biodegradable materials and are also affected by degradation time, the combined material is used For animal or human bone reinforcement materials, because of its relatively short degradation time, it is not conducive to the healing of animal or human bones

Method used

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  • Polyglycolic acid resin composite material and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Add an anhydrous ethanol solution containing 0.6%wt ethoxysilane to the nanoscale titanium oxide powder, mix evenly under the stirring of a high-speed mixer, put it in an exhaust oven with a temperature of 90°C, and dry the inorganic filler material for 2 hours Afterwards, add the high-speed mixer that fills the polyglycolic acid resin that the weight average molecular weight is 400,000, and the molecular weight distribution coefficient is 1.8 and stir for 30min; After the fiber reinforced material is input into the single-screw extruder for honey refining, the composite material is directly input into the feed port of the twin-screw extruder through the melt pipe of the head of the single-screw extruder, and is further honey-melted by the twin-screw extruder Extrude the head mold to obtain polyglycolic acid composite material particles with a particle size of 2mm and a length of 4mm, put them in a vacuum oven with a temperature of 80°C, and dry them for 18 hours; input ...

Embodiment 2

[0060] Add an anhydrous ethanol solution containing 0.3%wt ethoxysilane to the nanoscale titanium oxide powder, mix evenly under the stirring of a high-speed mixer, put it in an exhaust oven with a temperature of 80°C, and dry the inorganic filler material for 3 hours Afterwards, add the polyglycolic acid resin that fills weight-average molecular weight and be 200,000, and molecular weight distribution coefficient is 1.88 and stir 45min; After the fiber reinforced material is input into the single-screw extruder for honey refining, the composite material is directly input into the feed port of the twin-screw extruder through the melt pipe of the head of the single-screw extruder, and is further honey-melted by the twin-screw extruder Extrude the head mold to obtain polyglycolic acid composite material particles with a particle size of 3mm and a length of 6mm, put them in a vacuum oven at a temperature of 80-90°C, and dry them for 18-24 hours; The feeding tank of the injection ...

Embodiment 3

[0064] Add an anhydrous ethanol solution containing 0.6%wt ethoxysilane to 30%wt nano-scale magnesium oxide powder, mix evenly under the stirring of a high-speed mixer, put it in an exhaust oven with a temperature of 80°C, and fill it with inorganic After the material was dried for 3 hours, it was added to a high-speed mixer filled with a polyglycolic acid resin with a weight average molecular weight of 200,000 and a molecular weight distribution coefficient of 1.88 and stirred for 45 minutes; The benzamide fiber reinforced material is input into the single-screw extruder after honey refining, and the composite material is directly input into the feeding port of the twin-screw extruder through the melt pipe of the head of the single-screw extruder. Refining is extruded by its head die to obtain polyglycolic acid composite material particles with a particle size of 2 mm and a length of 4 mm, which are placed in a vacuum oven at a temperature of 80 ° C and dried for 24 hours; Th...

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Abstract

The invention provides a polyglycolic acid resin composite material and a manufacturing method thereof. The polyglycolic acid composite material is prepared from 30 to 40%wt of polyglycolic acid resin, 20 to 30%wt of inorganic filling material and 30 to 50% of reinforcing material. The manufacturing method comprises the steps: performing surface treatment on the inorganic filling material and reinforced fibers, smelting in a twin-screw extruder and extruding and forming by a machine head mould of the extruder. Except the inorganic filling material in the polyglycolic acid composite material, the other ingredients are all biocompatible materials compatible with animals or human bodies; thus, the composite material can serve as a reinforced material and a fracture fixing material of animal or human bones and further can be used as a packaging material and a well drilling downhole tool and component material.

Description

technical field [0001] The present invention belongs to the field of polymer material manufacturing, and it relates to the biodegradability of polyglycolic acid resin, and excellent performance in terms of formability and mechanical properties, and there is also a polyglycolic acid resin composite material with high-quality heat resistance and hydrolysis and its method of manufacture. Background technique [0002] Polymer materials are increasingly widely used in the medical field. In the research and development of medical polymer materials, degradable polymer materials have been applied in many fields such as surgical sutures, artificial skin, artificial blood vessels, bone fixation and repair, drug controlled release and red blood cell carriers. Research began in the 1960s. Initially, degradable materials were only used in slow-release drugs and sutures. In the 1980s, with the development of polymer polymerization technology and plastic processing technology, especially ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/58A61L31/12A61L31/14
CPCA61L27/446A61L27/58A61L31/128A61L31/148
Inventor 陈逊
Owner 陈逊