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Microemulsion containing radix arnebiae extract, preparation method and application thereof

A comfrey root and microemulsion technology, applied in the field of daily chemicals, can solve the problems of content determination of functional ingredient shikonnaphthoquinone, uneven quality of downstream products, no description of application conditions, etc., and achieves transdermal absorption, convenient application, Good dispersion effect

Active Publication Date: 2018-06-01
广州增城潮徽生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The defect of this method: there is no description of its application. In practical application, we found that shikonin prepared by subcritical fluid extraction technology is a paste substance with poor dispersion and solubility, which limits its application range.
The patent document with the application number CN201410216490.9 discloses a preparation method of multi-effect tea oil and comfrey paste. From the perspective of formula structure, the multi-effect tea oil and comfrey paste is an oil-water two-phase system, but only the emulsifying ability is very strong. Weak beeswax acts as an emulsifier, resulting in poor product stability and short shelf life
[0006] Generally speaking, most of the comfrey root extract products on the market do not carry out the content determination of the active ingredient shkonadione, which leads to uneven quality of the middle and downstream products in the application

Method used

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  • Microemulsion containing radix arnebiae extract, preparation method and application thereof
  • Microemulsion containing radix arnebiae extract, preparation method and application thereof
  • Microemulsion containing radix arnebiae extract, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1 contains the preparation of the microemulsion of comfrey root extract

[0059] (1) Preparation of comfrey oil: Weigh 5kg of comfrey roots, soak them in water for 24 hours, wash them, dry them at 55°C (for 4 hours), grind them with a powder machine, pass them through a 100-mesh sieve, and continue pulverizing those that cannot pass the sieve. Until all can be sieved; put the comfrey root powder into an 800-mesh filter bag, tie the bag tightly, place it at the bottom of the extraction tank, vacuum the extraction tank to -0.1MPa, and use the pressure difference to vacuum the n-butan in the solvent tank Pass alkanes into the extraction tank, make the solvent 5cm higher than the material, set the extraction temperature to 45°C, the extraction pressure to 0.5MPa, and extract 2 times continuously, each extraction time is 30min; vacuumize the desorption tank to -0.1 MPa, let the solvent in the extraction tank enter the analysis tank along the pressure difference, t...

Embodiment 2

[0065] Embodiment 2 contains the preparation of the microemulsion of comfrey root extract

[0066] (1) Preparation of comfrey oil: Weigh 6 kg of comfrey roots, soak them in water for 22 hours, wash them, dry them at 50°C for 5 hours, pulverize them with a powder machine, pass them through a 400-mesh sieve, and continue pulverizing those that cannot pass the sieve. Until all can be sieved; put the comfrey root powder into two 800-mesh filter bags, tie the bag mouths tightly respectively, place them at the bottom of the extraction tank, vacuum the extraction tank to -0.1MPa, and use the pressure difference to remove the solvent in the solvent tank. Put n-butane into the extraction tank, make the solvent 10cm higher than the material, set the extraction temperature to 48°C, and the extraction pressure to 0.8MPa, and extract 3 times continuously, each extraction time is 20min; vacuumize the analysis tank to -0.1MPa, let the solvent in the extraction tank enter the analysis tank al...

Embodiment 3

[0072] The application of microemulsion described in embodiment 3: the preparation of baby's buttock cream

[0073] Preparation formula: 8% of the microemulsion prepared in Example 1, 15% of white beeswax, 10% of glycerin, 0.5% of Vitamin E-Acetate, and 69.5% of AigloSy N (RG-01).

[0074] Preparation process: Weigh 15g of white beeswax, 10g of glycerin, and 69.5g of AigloSy N (RG-01) in a 150mL beaker, mix, heat to 85°C while stirring, and melt completely; cool down to 55°C, add 8g of Example 1 to prepare The microemulsion, 0.5gVitamin E-Acetate, stir evenly; While hot discharge filling, make baby's nape cream.

[0075] The content of shkonadione in the baby buttock cream is: 0.024%.

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Abstract

The invention discloses microemulsion containing radix arnebiae extract, a preparation method and application thereof. The preparation method comprises the following steps: extracting fat-soluble components in radix arnebiae by a subcritical fluid extraction technology, then dispersing the obtained radix arnebiae extract in camellia oil and preparing into radix arnebiae oil; uniformly mixing the radix arnebiae oil with a dispersing agent, then adding water-in-oil type co-emulsifier and a water-in-oil type emulsifier, heating to 70-78 DEG C and preparing into an oil phase of the microemulsion;heating water to 65-75 DEG C and preparing into a water phase of the microemulsion; under a stirring condition, adding the water phase into the oil phase and obtaining the microemulsion containing theradix arnebiae extract. The microemulsion containing the radix arnebiae extract disclosed by the invention has the advantages of small particle diameter, good dispersity, high stability and long shelf life, and is suitable for being applied to cosmetics.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and in particular relates to a microemulsion containing comfrey root extract and a preparation method and application thereof. Background technique [0002] Comfrey is a perennial herbaceous plant belonging to the family Boraginaceae. It has the functions of antibacterial, anti-inflammatory, promoting cell regeneration, and detoxifying rashes. [0003] At present, there are many comfrey products used in the market, the formula of which is mainly composed of comfrey and other traditional Chinese medicine ingredients and sesame oil heated to make comfrey oil, but studies have shown that the active ingredients of comfrey, naphthoquinone compounds, At 80°C, the stability drops sharply and is easily damaged. Other comfrey extracts prepared by alcohol extraction and water extraction contain many ingredients that are harmful to the human body such as hormones and pigments. The patent literature with the...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/92A61K8/06A61Q19/00A61Q17/00A61P31/02A61P31/04
CPCA61K8/068A61K8/922A61K8/97A61K2800/805A61Q17/005A61Q19/00
Inventor 徐进黄桂州徐俊伟郑华生谢培镇陈杰烽晏洁张鹏程建华
Owner 广州增城潮徽生物技术有限公司
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