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Bioactive borophosphate glass and preparation method thereof

A technology of bioactive glass and borophosphorus, which is applied in the field of biomedicine, can solve the problems of affecting wound healing, slow degradation rate, and affecting tissue growth, etc., and achieve the effects of improving biocompatibility, promoting complexation, and increasing repair speed

Active Publication Date: 2018-06-15
FUZHOU RUIKE BULANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the silicate system bioglass proposed by Professor Hench to the commercialized 45S5 bioactive glass in 1971, the performance of materials has been continuously improved (Zhong Jipin, Journal of Inorganic Materials, 1995), and a large number of patents have also emerged, such as CN201210518111.2, among which Provides a method for preparing strontium-containing bioglass powder by sol-gel method, and further provides a preparation method for making strontium-containing porous bioglass scaffold, such as CN201710198500.4, which provides a biological Glass dressing and its drug delivery device, but most of the current disclosed technologies focus on the phosphate and silicate system bioglass system, and its disadvantage is that the degradation rate of the two in the human body is too slow, which affects the growth of tissue, thereby affecting wound healing

Method used

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  • Bioactive borophosphate glass and preparation method thereof
  • Bioactive borophosphate glass and preparation method thereof
  • Bioactive borophosphate glass and preparation method thereof

Examples

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preparation example Construction

[0029] A boron-phosphorous bioactive glass and a preparation method thereof, the selected initial bioglass is boron-based glass, and the raw material is composed of B 2 o 3 , MgO, CaO, Na 2 O, K 2 The mass ratio of O and SrO is 45~60:2~10:15~25:3~10:10~15:1~8. The melting temperature of the initial glass is 1000-1350°C, and the holding time is 0.5-4 hours, preferably 1100-1300°C, and the holding time is 0.5-2 hours. The composition of the impregnation solution is CaCl 2 , (NH 4 ) 2 HPO 4 、K 2 HPO 4 ×3H 2 O, HCl, dissolved in 1L of ultra-pure water, the mass ratio is 5~20:15~25:60~70:0.1~2. The specific operation steps are as follows:

[0030] (1) Clean the experimental equipment used in this method, such as beakers, stirring rods, measuring cylinders, etc., with ultrapure water, and carry out disinfection and sterilization treatment;

[0031] (2) Grind and sieve the boron-based glass to obtain glass powder with a particle size of 30-45 μm, and perform disinfection ...

Embodiment 1

[0047] Embodiment 1: preparation of material and performance test result

[0048] According to the proportioning of each component in Table 1, a certain amount of analytically pure raw material (B 2 o3 , MgO, CaO, Na 2 O, K 2 O and SrO), after mixing evenly, put the powder into a platinum crucible, and put it in a box-type resistance furnace for melting (melting temperature is 1350°C, holding time is 2 hours). Then pour the melt into deionized water for rapid cooling, dry to obtain glass frit, and obtain glass powder after ball milling. Weigh a certain amount of CaCl 2 , (NH 4 ) 2 HPO 4 、K 2 HPO 4 ×3H 2 O, HCl (the mass ratio is 5:23:70:2), dissolved in 1L of ultrapure water. Weigh 100g of glass powder, put it into 1L of impregnating solution, and keep stirring for 6h. After the stirring is completed, the impregnated glass powder is separated by vacuum filtration, dried and made into a biological glass dressing for later use. The dressings were used for wound heali...

Embodiment 2

[0049] Embodiment 2: preparation of material and performance test result

[0050] According to the proportioning of each component in Table 1, a certain amount of analytically pure raw material (B 2 o 3 , MgO, CaO, Na 2 O, K 2 O and SrO), after mixing evenly, put the powder into a platinum crucible, and put it in a box-type resistance furnace for melting (melting temperature is 1300°C, holding time is 2 hours). Then pour the melt into deionized water for rapid cooling, dry to obtain glass frit, and obtain glass powder after ball milling. Weigh a certain amount of CaCl 2 , (NH 4 ) 2 HPO 4 、K 2 HPO 4 ×3H 2 O, HCl (the mass ratio is 10:20:68.5:1.5), dissolved in 1L of ultrapure water. Weigh 100g of glass powder, put it into 1L of impregnating solution, and keep stirring for 6h. After the stirring is completed, the impregnated glass powder is separated by vacuum filtration, dried and made into a biological glass dressing for later use. The dressings were used for woun...

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Abstract

The invention discloses bioactive borophosphate glass and a preparation method of the bioactive borophosphate glass. The method comprises the steps of preparing boron glass by a fusion and cooling method, and then steeping in a solution containing phosphorus ions to form the double-layer bioactive glass taking porous phosphate as a shell and borate as a kernel, wherein the boron glass comprises the following raw materials: B2O3, MgO, CaO, Na2O, K2O and SrO at a mass ratio of (45-60):(2-10):(15-25):(3-10):(10-15):(1-8). A degradation rate of a borate glass structure in an organism can be controlled, and the biocompatibility of a biological material can be improved by the porous shell; and therefore, the repairing speed of an injured body surface tissue is significantly increased.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a bioactive glass used for repairing body surface tissue damage and a preparation method thereof. Background technique [0002] With the rapid development of science and technology in today's society, the types and quantities of vehicles are constantly increasing, and traffic congestion has appeared in major first- and second-tier cities. These changes have directly led to frequent traffic accidents, resulting in a sharp increase in the number of deaths and injuries. In major traffic accidents, the majority of patients suffer from trauma to the body surface, and accelerating the repair of body surface tissue damage has become everyone's demand. [0003] On the other hand, accelerating the repair of body surface tissue when the body surface is damaged can reduce the healing time and create more social value. A lot of research has been done on bioglass international...

Claims

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Application Information

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IPC IPC(8): C03C3/14C03C12/00C03C4/00A61L27/10A61L27/58A61L27/50A61L27/54
CPCA61L27/10A61L27/50A61L27/54A61L27/58A61L2300/112A61L2300/412C03C3/14C03C4/0007C03C12/00A61L15/18C03C4/0014
Inventor 刘鸿琳陈瑞果黄培琰李倩王俊峰张腾傅宇宏
Owner FUZHOU RUIKE BULANG MEDICAL TECH CO LTD
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