Scaffold for repairing articular subchondral bone

A technology for articular cartilage and bone repair, applied in the field of prostheses, can solve problems such as collapse, damage, and bionic human joints, and achieve the effects of excellent mechanical properties, good seepage characteristics, and good cushioning functions

Active Publication Date: 2018-06-26
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although people have carried out a lot of research, the structure of the scaffold for articular subchondral bone repair is still unreasonable, and it has not been able to effectively mimic human joints. The repair scaffold for subchondral bone is prone to collapse and damage, and its repair and regeneration effects are not good.

Method used

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  • Scaffold for repairing articular subchondral bone
  • Scaffold for repairing articular subchondral bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] see figure 1 , the scaffold for articular subchondral bone repair in this embodiment is composed of a porous salt layer 1 and a porous metal material layer 2 from top to bottom. The porous salt layer 1 is a porous inorganic salt layer, prepared by porous hydroxyapatite, with a pore size of 3 μm-6 μm, a porosity of 43%, and a thickness of 0.5 mm; the porous metal material layer 1 is a porous titanium alloy, the material is TC4, Wherein the porous titanium alloy has two layers, see figure 1 , wherein the upper layer 2-1 connected to the porous salt layer has a pore diameter of 3 μm-10 μm, a porosity of 38%, and a thickness of 2 mm; the lower layer 2-2 has a pore diameter of 100 μm-450 μm, a porosity of 82%, and a thickness of 4 mm , the pores in each layer of porous titanium alloy and between layers are interconnected. The preparation method of the material for artificial joint repair is as follows:

[0025] (1) The porous titanium alloy upper layer was prepared by mix...

Embodiment 2

[0030] The scaffold for articular subchondral bone repair in this example is similar to Example 1, except that the porous metal material layer is porous niobium, the pore diameter of the upper layer is 75 μm-100 μm, and the porosity is 43%, and the pore diameter of the lower layer is 400 μm-700 μm , the porosity is 78%, and the pores inside and between the layers of porous niobium are interconnected. The pore diameter of the porous hydroxyapatite is 5 μm-10 μm, and the porosity is 36%. The preparation method is similar to Example 1.

Embodiment 3

[0032] The scaffold for articular subchondral bone repair in this example is similar to Example 1, except that the porous metal material layer is made of nickel-titanium alloy, the pore diameter of the upper layer is 50 μm-80 μm, the porosity is 39%, and the pore diameter of the lower layer is 700 μm -1000μm, the porosity is 72%, the pores inside and between layers of porous nickel-titanium alloy are interconnected, the porous salt layer is made of ammonium hyaluronate as raw material, its pore size is 4μm-8μm, and the porosity is 38 %, the preparation method is similar to Example 1.

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Abstract

The invention discloses a scaffold for repairing an articular subchondral bone. The scaffold is composed of a porous salt layer and a porous metal material layer from top to bottom. The porous metal material layer is a gradient porous metal material layer. The scaffold realizes articular subchondral bone bionic simulation. Through the scaffold, the articular subchondral bone can bear complex and large load, has good buffering functions, realizes good force transmission, has the strength higher than that of the porous non-metallic scaffold and solves the problem that the single-pore size high-porosity porous metal material has poor rigidity. The porous salt layer can be fused with the cartilage layer. The scaffold has good transfusion characteristics and a pore size conducive to cell and nutrient solution migration and keeping of appropriate pressure of the liquid in the joint. The pore size and material design of the scaffold are conducive to migration, colonization, differentiation and proliferation and is a real articular subchondral bone repair and regeneration scaffold.

Description

technical field [0001] The invention relates to a prosthesis, in particular to a bracket for articular subchondral bone repair. Background technique [0002] Human joints have a complex structure, and subchondral bone is an important part of the joints. When the human body moves, the joints bear large complex loads. When moving, the joints bear even 7-9 times the body weight. The articular subchondral bone places high demands. With the improvement of socio-economic level, the incidence of severe trauma such as traffic accidents is also increasing rapidly. In my country, the joint damage caused by trauma affects the lives of hundreds of thousands of people every year, and about 100,000 people need artificial joint replacement every year. The incidence of joints caused by disease and social aging is also increasing. Osteoarthritis can cause joint damage or defect, which can cause damage or defect of articular subchondral bone. Clinically, simple articular cartilage damage R...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/12A61L27/06A61L27/04A61L27/56A61L27/50
CPCA61L27/045A61L27/047A61L27/06A61L27/12A61L27/20A61L27/50A61L27/56A61L2430/06A61L2430/24C08L5/08
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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