Medical hydrogel dressing capable of stopping bleeding and promoting healing and preparation method thereof

A technology of healing hydrogel and distilled water, applied in pharmaceutical formulations, medical science, bandages, etc., can solve problems such as unsatisfactory hemostasis effect and poor skin healing effect, achieve good hemostasis effect and improve the effect of healing rate

Inactive Publication Date: 2018-07-13
苏州凌科特新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dressings currently put into production for clinical use generally have unsatisfactory hemostatic effect and poor skin healing effect after use, so it still needs to be further improved and improved to promote wound healing or muscle regeneration

Method used

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  • Medical hydrogel dressing capable of stopping bleeding and promoting healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A medical hydrogel dressing for hemostasis and healing, prepared from the following components by weight: 2 g of polyvinyl alcohol, 3 parts of hyaluronic acid, 10 parts of fibrin glue, 5 parts of calcium chloride, 3 parts of glycerol, 6 parts of quaternary ammonium chitosan, 20 parts of medical distilled water, 1.5 parts of white plum extract, 0.8 parts of Maizuru two leaves extract, 3 parts of Hibiscus Venus fern extract, 0.8 parts of Euphorbia alpine extract, Larnia thorn flower Extract 0.5 parts.

[0021] The preparation method of the above-mentioned medical hydrogel dressing for hemostasis and healing is as follows: (1) Take Baimei, Maiheca bilobata, Hibiscus Venus fern and extract them with 65% ethanol at room temperature for 4 hours respectively. The ratio of solid to liquid is 1:4. Ethyl ester extraction, the extracts were dissolved in ether respectively, then distilled water was added for distillation, the distillate was collected, dehydrated with anhydrous sodi...

Embodiment 2

[0023] A medical hydrogel dressing for hemostasis and healing, prepared from the following components by weight: 4 g of polyvinyl alcohol, 8 parts of hyaluronic acid, 3 parts of fibrin glue, 2 parts of calcium chloride, 10 parts of glycerol, 3 parts of quaternary ammonium chitosan, 40 parts of medical distilled water, 2.5 parts of white plum extract, 1.8 parts of Maizuru two leaves extract, 2 parts of Hibiscus Venus fern extract, 1.5 parts of Euphorbia alpine extract, Larnia thorn flower Extract 1.2 parts.

[0024] The preparation method of the above-mentioned medical hydrogel dressing for hemostasis and healing is as follows: (1) Take Baimei, Maiheca bilobata, and Hibiscus Venus fern, and extract them with 65% ethanol at room temperature for 2 hours, with a solid-liquid ratio of 1:2, and use acetic acid Ethyl ester extraction, the extracts were dissolved in ether respectively, then distilled water was added for distillation, the distillate was collected, dehydrated with anhyd...

Embodiment 3

[0026] A medical hydrogel dressing for hemostasis and healing, prepared from the following ingredients by weight: 2.5 g of polyvinyl alcohol, 4 parts of hyaluronic acid, 8 parts of fibrin glue, 4 parts of calcium chloride, and 8 parts of glycerol , 5 parts of quaternary ammonium chitosan, 25 parts of medical distilled water, 1.8 parts of white plum extract, 1.6 parts of Maihe grass extract, 2.2 parts of hibiscus Venus fern extract, 1 part of Euphorbia alpine extract, hare lip thorn Flower extract 1 part.

[0027] The preparation method of the above-mentioned medical hydrogel dressing for hemostasis and healing is as follows: (1) Take Baimei, Maiheca bilobata, Hibiscus Venus fern and extract them with 65% ethanol at room temperature for 2.5 hours respectively. The ratio of solid to liquid is 1:3. Ethyl acetate extraction, add ether to dissolve the extracts, then add distilled water for distillation, collect the distillate, dehydrate with anhydrous sodium sulfate, and prepare Ba...

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Abstract

The invention provides medical hydrogel dressing capable of stopping bleeding and promoting healing and a preparation method thereof. The preparation method comprises the following steps: (1) preparing fructus armeniacae mume extract, extract of herba maianthemi bifolii and herba parathelypteris nipponicae extract; (2) preparing herba euphorbiae stracheyi boiss extract andflos lagochili leiacanthi extract; (3) adding polyvinyl alcohol and hyaluronic acid into a medical distilled water solution, and stirring at a temperature of 90 DEG C to form a uniform solution; (4) cooling to a temperaturebeing 60 DEG C, adding quaternary ammonium salt chitosan, fibrin glue and calcium chloride in mass ratio, keeping rotation speed, and contiuously stirring; and (5) adding extract prepared in steps (1)and (2), and modulating glycerol into a solution with proper viscosity, strirlizing, and storring for 12-24 hours at temperature being 4 DEG C. The medical hydrogel dressing capable of stopping bleeding and promoting healing can quickly stop bleeding, and further has the effect of prompting the wound to heal.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical hydrogel dressing for hemostasis and healing and a preparation method thereof. Background technique [0002] The hydrogel medical dressing has good hydrophilicity, can absorb the exudate of the wound, and does not adhere to the wound, so the new granulation or epithelial tissue will not be damaged when changing the dressing. To apply, the doctor sticks the hydrogel dressing on the surface of the patient's skin, and then secures it to the wound with adhesive tape or a polyurethane film. When replacing, just gently peel off the hydrogel, or rinse it off with normal saline. The replacement process has little effect on the wound surface, which is unmatched by various medical gauzes. [0003] Compared with other commonly used dressings, the hydrogel does not shed impurities such as fibers on the wound. As the wound heals, the hydrogel can be easily rinsed from the wound. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0014A61L26/0023A61L26/0042A61L26/0066A61L26/008A61L2300/30A61L2300/412A61L2300/45A61L2400/04C08L29/04C08L5/08C08L89/00
Inventor 王鹤明
Owner 苏州凌科特新材料有限公司
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