Preparation method of bioactive glass-wrapping modified zirconium oxide dental ceramic material

A technology of bioactive glass and dental ceramics, used in dental preparations, dentistry, dental prostheses, etc., can solve the problems of low interfacial bonding force, decreased mechanical strength of ceramics, uncertain effect, etc., to promote proliferation and osteogenic differentiation. , Improve the effect of repairing, improve the biological activity

Inactive Publication Date: 2018-07-17
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Around this mechanism, there are mainly the following three modification methods: the first is to directly compound the second phase material with relatively good biological activity in the zirconia matrix, such as hydroxyapatite, bioactive glass, calcium phosphate, etc., although biological The activity is significantly improved, but because the strength of the second phase is low, it will cause a sharp drop in the overall mechanical strength of the ceramic; Depositing bioactive coatings, such as phosphate coatings, bioactive glass coatings, and hydroxyapatite coatings, this method can significantly improve the bioactivity of ceramic surfaces to a certain extent, and is widely used, but because the surface The bonding between the coating and the substrate is mainly ph

Method used

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  • Preparation method of bioactive glass-wrapping modified zirconium oxide dental ceramic material
  • Preparation method of bioactive glass-wrapping modified zirconium oxide dental ceramic material
  • Preparation method of bioactive glass-wrapping modified zirconium oxide dental ceramic material

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Experimental program
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Effect test

Embodiment 1

[0050] The application composition of this embodiment is SiO 2 ,40mol%; CaO,56mol%; P 2 o 5 , 4mol% bioactive glass to improve the bioactivity of yttrium partially stabilized tetragonal zirconia ceramics (Y-TZP), the specific process includes:

[0051] (1) According to the composition ratio, tetraethyl orthosilicate (TEOS, Si(OC 2 h 5 ) 4 )) dissolved in deionized water (orthosilicate: deionized water molar ratio is 1:4), add 0.1mol / L of HNO 3 Adjust the pH to 1.67, stir with a mixer at a speed of 250r / min, and the stirring time is 60min;

[0052] (2) After observing that the solution in step (1) becomes clear, add triethyl phosphate (TEP, OP(OC 2 H5) 3 ), stirring at a speed of 250r / min, the stirring time is 60min;

[0053] (3) after the solution of observation step (2) becomes clear, add calcium nitrate (Ca(NO 3 ) 2 4H 2 (0), stirring at a speed of 250r / min, the stirring time is 60min;

[0054] (4) Obtain the bioactive glass precursor sol after the solution in th...

Embodiment 2

[0070] The application composition of this embodiment is SiO 2 ,90mol%; CaO,18mol%; P 2 o 5 ,1mol% bioactive glass to improve the bioactivity of magnesium partially stabilized tetragonal zirconia ceramics (Mg-TZP), the specific process includes:

[0071] (1) According to the composition ratio, tetraethyl orthosilicate (TEOS, Si(OC 2 h 5 ) 4 )), dissolved in deionized water (orthosilicate: deionized water molar ratio is 1:12), adding 0.1mol / L of HNO 3 Adjust the pH to 6, stir with a mixer at a speed of 1000r / min, and the stirring time is 50min;

[0072] (2) After observing that the solution in step (1) becomes clear, triethyl phosphate (TEP, OP(OC) 2 H5) 3 ), stirring at a speed of 1000r / min, the stirring time is 50min;

[0073] (3) After the solution of observation step (2) becomes clear, the calcium nitrate (Ca(NO) added in according to the composition ratio 3 ) 2 4H 2 (0), stirring at a speed of 250r / min, the stirring time is 50min;

[0074] (4) Obtain the bioact...

Embodiment 3

[0084] The application composition of this embodiment is SiO 2 , 65mol%; CaO, 33.5mol%; P 2 o 5 , 1.5mol% bioactive glass to improve the bioactivity of aluminum-toughened tetragonal zirconia ceramics (Al-TZP), the specific process includes:

[0085] (1) According to the composition ratio, tetraethyl orthosilicate (TEOS, Si(OC 2 h 5 ) 4 )), dissolved in deionized water (orthosilicate: deionized water molar ratio is 1:10), adding 0.1mol / L of HNO 3 Adjust the pH to 14, stir with a mixer at a speed of 800r / min, and the stirring time is 30min;

[0086] (2) After observing that the solution in step (1) becomes clear, triethyl phosphate (TEP, OP(OC) 2 H5) 3 ), stirred at a speed of 800r / min, and the stirring time was 30min;

[0087] (3) After the solution of observation step (2) becomes clear, the calcium nitrate (Ca(NO) added in according to the composition ratio 3 ) 2 4H 2 (0), stirring at a speed of 800r / min, the stirring time is 30min;

[0088] (4) Obtain the bioactiv...

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Abstract

The invention discloses a preparation method of a bioactive glass-wrapping modified zirconium oxide dental ceramic material. The method comprises the specific steps that a hydrolysable silicon-containing compound, triethyl phosphate and nitrate are dissolved in a solvent, the pH value is adjusted, the mixed solution is subjected to a hydrolytic condensation reaction, and bioactive glass precursorsol is obtained; a zirconium oxide suspension solution which is evenly dispersed in advance is added to the bioactive glass precursor sol and evenly dispersed, the sol is converted into gel through aging, a layer of extremely-thin bioactive glass wraps the peripheries of zirconium oxide particles, and after high-temperature sintering, the bioactive glass-wrapping modified zirconium oxide dental ceramic material is obtained. The zirconium oxide dental ceramic material has good biological activity and excellent mechanical properties, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells can also be promoted at the same time, and accordingly the material helps to improve the osseointegration capacity; the effect of repairing the dental material is improved, the wider clinical application of the material is promoted, and the material has high social economic value.

Description

technical field [0001] The invention relates to the field of dental restoration medical materials, in particular to a method for preparing a bioactive glass-coated modified zirconia dental ceramic material. Background technique [0002] Tooth loss due to dental caries, periodontitis, dental trauma, etc. is one of the most common oral diseases faced by humans. Before the 1950s, The professor proposed for the first time to use titanium metal to replace the gold and precious metals in the past to become a new oral implant. Since then, dental implants have been hailed as the "third set of teeth" for human beings due to their strong functions and good retention. At present, the mainstream planting products on the market are titanium metal and its alloys. Although they are widely used, they still have problems such as poor aesthetics, toxicity, and poor biomechanical adaptability. Bioceramics, especially zirconia ceramics, have more and more clinical application potential becau...

Claims

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Application Information

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IPC IPC(8): C04B35/48C04B35/628A61K6/027
CPCA61K6/833C04B35/481C04B35/62823C04B2235/3217C04B2235/36C04B2235/443C04B2235/483C04B2235/77C04B2235/96
Inventor 叶建东柯金环
Owner SOUTH CHINA UNIV OF TECH
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