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A kind of raw material medicine of ginseng fruit saponins, preparation, preparation method, and application thereof

A technology of ginseng fruit and total saponins, which is applied in the direction of pharmaceutical formulations, plant raw materials, anti-toxins, etc., can solve problems such as application limitations, achieve the effects of shortening coating time, improving performance and efficacy, and avoiding negative effects

Active Publication Date: 2020-12-25
JILIN JICHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs are prone to drug dependence and other side effects, which limit the application.

Method used

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  • A kind of raw material medicine of ginseng fruit saponins, preparation, preparation method, and application thereof
  • A kind of raw material medicine of ginseng fruit saponins, preparation, preparation method, and application thereof
  • A kind of raw material medicine of ginseng fruit saponins, preparation, preparation method, and application thereof

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preparation example Construction

[0030] In a third aspect, the present invention provides a method for preparing a raw material drug of ginseng fruit saponins, comprising the following steps:

[0031] Step 1. Collection: Collect fresh ginseng fruits in autumn, wash them, and separate the pulp.

[0032] The above separation method is as follows: after soaking the washed ginseng fruit in tap water for 2-4 days (preferably 3 days), the pulp is located in the upper layer of the container, the seeds are located in the lower layer of the container, and the pulp is obtained by filtering.

[0033] Step 2, homogenizing: homogenizing the above pulp with a beater to obtain pulp.

[0034] As a preferred embodiment, the above-mentioned fruit pulp is first subjected to ultrasonic treatment, so that the active ingredients of the ginseng fruit are further dissolved out of the cells, and then the subsequent soaking treatment is performed. In the above-mentioned ultrasonic treatment, the above-mentioned pulp and absolute etha...

Embodiment 1

[0067] The preparation method of the ginseng fruit saponins crude drug of the present embodiment comprises the following steps:

[0068] (1) Collection: Collect fresh ginseng fruits in autumn, soak them in tap water for 3 days, then filter and separate the pulp.

[0069] (2) Homogenization: the above-mentioned pulp is processed into pulp with a beater.

[0070] (3) Soaking: extract the above fruit pulp, add the same mass of purified water at 20° C. for cold soaking for 3.5 hours, and obtain supernatant and sediment.

[0071] (4) Filtration for the first time: absorb the above supernatant, and then filter with a 100-mesh filter to obtain the first filtrate and filter residue.

[0072] (5) Extraction: collect the above-mentioned sediment and filter residue, and decoct and extract twice: the amount of purified water added to the first decocting and extracting treatment is 3 times that of the solid, and the time is 2 hours; the second decocting and extracting treatment The amoun...

Embodiment 2

[0111] The preparation method of the total ginseng fruit saponins crude drug in this example is referred to Example 1, and the difference from Example 1 is that an ultrasonic step is added between step (2) homogenization and step (3), as follows:

[0112] The fruit pulp obtained in step (2) and absolute ethanol were mixed according to the mass ratio of 1:3, ultrasonically extracted at room temperature for 8 minutes, the ultrasonic frequency was 30KHz, and the power was 220W to obtain an ultrasonic extraction mixture. The sonicated mixture is then soaked.

[0113] The yield in this implementation was 0.93%.

[0114] The preparation method of the total ginseng fruit saponins tablet of this embodiment is the same as that of embodiment 1.

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Abstract

The invention belongs to the field of processing of traditional-Chinese-medicine bulk drugs, and particularly relates to a bulk drug with ginseng-fruit total saponin, a preparation, a preparation method and application of the bulk drug or the preparation. The yield of the bulk drug with ginseng-fruit total saponin is up to 0.8% or above, and the extracting efficiency is high. The content of the ginseng total saponin in the bulk drug with the ginseng-fruit total saponin (calculated by ginseng saponin Re) is 90% or above, and the bulk drug with the ginseng-fruit total saponin can be applied to preparation of medicines for resisting depression and / or resisting angina pectoris and / or resisting fatigue. The preparation method comprises the steps of absorbing with macroporous resin, eluting, concentrating and spray drying. The preparation method has the beneficial effects that all the steps and parameters are in close matching and have a synergistic effect, reasonable parameters are especially adopted in the processes of absorption with the microporous resin and eluting, so that the property and the effect of a product are improved by the steps and the parameters commonly.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a raw material drug of ginseng fruit saponins, a preparation, a preparation method and an application thereof. Background technique [0002] Ginseng fruit is the fruit of Araliaceae plant ginseng (Panax ginseng C.A.Mey.). The active components of ginseng fruit saponins extracted from ripe fresh ginseng fruit include: saponins, ginseng polysaccharides, volatile oils, amino acids and polypeptides. It has various physiological effects such as improving the body's immunity, anti-aging, promoting learning and memory functions, detoxification, and antibacterial, and has good effects on diseases such as cardiovascular diseases, osteoporosis, tumors, inflammation, and peptic ulcers. However, in the prior art, in the extraction process of total saponins of ginseng fruit using ginseng or American ginseng fresh pulp as raw material, the content of active ing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P25/24A61P9/10A61P39/00A61K131/00
CPCA61K36/258A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/55
Inventor 曲风采
Owner JILIN JICHUN PHARMA
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