Carboxymethyl dextrin/chitosan composite nanogel as well as preparation method and application thereof

A carboxymethyl dextrin and nanogel technology, applied in the field of emulsifiers, can solve problems such as application limitations, and achieve the effects of wide use and long-term storage stability

Active Publication Date: 2018-08-03
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its application in the food and pharmaceutical industries is greatly limited due to issues such as its biodegradability and biocompatibility

Method used

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Examples

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preparation example Construction

[0026] One aspect of the embodiments of the present invention provides a preparation method of carboxymethyldextrin / chitosan composite nanogel, which includes:

[0027] Carboxymethyldextrin and chitosan are electrostatically complexed to form a carboxymethyldextrin / chitosan composite nanogel.

[0028] In some embodiments, the preparation method specifically includes: making carboxymethyldextrin and chitosan in a volume ratio of 1:1 to 4 in a reaction system with a pH of 3 to 6 at 25 to 30°C. Mix and form a carboxymethyldextrin / chitosan composite nanogel through electrostatic complexation.

[0029] In some embodiments, the preparation method further includes: performing an alkalization reaction of dextrin with a uniform degree of polymerization at 35-40°C for 3 to 5 hours, and then making the paste containing the paste under the condition of a pH of 6.5 to 7.5 The mixed system of refined and monochloroacetic acid undergoes etherification reaction at 40~45℃ for 6~8h to obtain carboxym...

Embodiment 1

[0063] Disperse waxy corn starch in acetic acid buffer (0.05M, pH5.0) and boil for 35min, then autoclave at 121℃ for 1h to make it completely gelatinized, then cool it to 50℃, add isoamylase (60u / g) Hydrolysis for 24h, then add an excess of 95% absolute ethanol to terminate the hydrolysis reaction, collect the reaction solution, collect the precipitate after centrifugation at 3800rpm for 15min, and wash it with 95% ethanol three times, and then put it in 45℃ Dry in an oven for 24 hours, take out the dried material and grind it into a finely divided powder in a mortar, then dissolve the starch hydrolysate in distilled water to prepare a 1.0%-4.0% dextrin solution, and add a certain amount of polyethylene The alcohol is heated and stirred until the polyethylene glycol is dissolved and the solution is clear. Cool to 25°C in a water bath for 24 hours at room temperature. After the precipitate is obtained, centrifuge at 4500g for 10 minutes. Use chloroform to wash off the polyethyle...

Embodiment 2

[0065] The waxy corn starch was dispersed in acetic acid buffer (0.05M, pH5.0) and boiled for 35min, then autoclaved at 121℃ for 1h to make it completely gelatinized, then cooled to 55℃, added isoamylase (60u / g) Hydrolysis for 20h, then add an excess of 95% absolute ethanol to terminate the hydrolysis reaction, collect the reaction solution, collect the precipitate after centrifugation at 3800rpm for 15min, and wash it with 95% ethanol three times, and then put it in 45°C Dry in an oven for 24 hours, take out the dried material and grind it into a finely divided powder in a mortar, then dissolve the starch hydrolysate in distilled water to prepare a 1.0%-4.0% dextrin solution, and add a certain amount of polyethylene The alcohol is heated and stirred until the polyethylene glycol is dissolved and the solution is clear. Cool to 25°C in a water bath for 24 hours at room temperature. After the precipitate is obtained, centrifuge at 4500g for 10 minutes. Use chloroform to wash off ...

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Abstract

The invention discloses carboxymethyl dextrin / chitosan composite nanogel as well as a preparation method and application thereof. The preparation method of the carboxymethyl dextrin / chitosan compositenanogel comprises the following steps: electrostatically complexing carboxymethyl dextrin and chitosan to form the carboxymethyl dextrin and chitosan composite nanogel. The preparation method of O / Wpickering emulsion comprises the following steps: uniformly mixing an oil phase and the carboxymethyl dextrin / chitosan composite nanogel by adopting a high pressure homogenization technique to obtainthe O / W pickering emulsion. The pickering emulsion prepared by the invention has good emulsification performance, and colloidal particles can be irreversibly absorbed and anchored on an oil / water interface to form a compact layer, so that the steric-hinerance effect is improved, thereby improving the stability of the emulsion, significantly improving the agglomeration resistance and Ostwald curingcapability of the emulsion, having long-term storage stability, and having wide application in the fields of food, medicine, cosmetics and the like.

Description

Technical field [0001] The invention relates to an O / W type Pickering emulsion, in particular to a carboxymethyldextrin / chitosan composite nanogel and a preparation method thereof, and the carboxymethyldextrin / chitosan composite nanogel The stable O / W type Pickering emulsion prepared by rubber and its preparation method and application belong to the technical field of emulsifiers. Background technique [0002] Pickering emulsion refers to an emulsion stabilized by solid colloidal particles. It does not use surfactants in the preparation process and has the advantages of good stability and biocompatibility. Generally speaking, inorganic particles have received widespread attention in Pickering emulsions and their extended applications. Most of the current understanding of Pickering emulsion is the conclusion drawn from the model Pickering system stabilized by silica nanoparticles with or without surface modification. However, due to its biodegradability and biocompatibility issu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L3/08C08B31/12C08B30/18
CPCC08B30/18C08B31/12C08J3/075C08J2303/08C08J2305/08C08J2403/08C08J2405/08
Inventor 章宝李小敏陈寒青潘怡
Owner HEFEI UNIV OF TECH
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