Synthesizing method of beta-keto sulfone compound

Abstract

The invention discloses a synthesizing method of a beta-keto sulfone compound. The synthesizing method includes: mixing a compound I as shown in formula I and a compound II as shown in formula II withan oxidizing agent to obtain mixed liquid, and adding a copper catalyst into the mixed liquid by three times; sequentially subjecting the mixture obtained after the reaction to cation exchange membrane processing and post-processing to obtain the beta-keto sulfone compound as shown in formula III. The synthesizing method has the advantages that the compound I is used as the raw material, the rawmaterial is simple and easy to obtain, the synthesizing route is simple, side reaction is reduced, and high product purity and yield are achieved; the used copper catalyst is cheap and has high specificity to the reaction of the method, the copper catalyst is added by three times and coordinated with the other raw materials, the mixture obtained after the reaction is sequentially subjected to cation exchange membrane processing and post-processing, and the problem that a metal catalyst is hard to separate in the prior art can be well solved.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a synthesis method of β-carbonyl sulfone compounds. Background technique [0002] Enaminones are an important class of organic compounds, widely used in organic synthesis, especially in the synthesis of heterocyclic compounds. Because the molecule contains a conjugated N-C=C-C=O functional group structure, its physical and chemical properties are different from those of general ketones. It has both the nucleophilicity of enamine and the electrophilicity of enone. As a highly active organic intermediate, enaminone is a key intermediate in the synthesis of nitrogen-containing heterocyclic compounds such as pyridine, pyrrole, indole, oxazolidine, pyrimidinone, quinoline, and alkaloids (MingLietc.ChineseJournalofOrganicChemistry, 2006 , 26, 1192-1207). Through the study of the reaction mechanism, it is found that this type of reaction generally undergoes the p...

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Problems solved by technology

At present, there are some methods for synthesizing β-carbonyl sulfone compounds, such as using 2-bromoacetophenone (or 2-chloroacetophenone) and sodium sulfinate as raw materials and preparing them through sulfonation reaction under alkaline conditions. , but this kind of synthetic method requires the use of strong base or ionic liquid in most cases, which requires too high requirements on the reaction equipment, and at the same time, a large amount of heat is released during the reaction process, which is likely to cause production hazards

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