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Benzalkonium chloride external solution and preparation method thereof

A benzalkonium chloride and solution technology, applied in the field of benzalkonium chloride topical solution and preparation thereof, can solve the problems of insufficient absorption, poor antibacterial effect, skin irritation and the like, and achieves improvement of insufficient absorption and unstable antibacterial effect. , improve the absorption effect

Active Publication Date: 2018-08-21
HAINAN HUALON PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to: overcome the problems of insufficient absorption, easy irritation to the skin, poor antibacterial effect and the like in the existing common benzalkonium chloride preparations, and provide a product with high skin absorption, low irritation, and good antibacterial stability. Benzalkonium chloride topical solution and preparation method thereof

Method used

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  • Benzalkonium chloride external solution and preparation method thereof
  • Benzalkonium chloride external solution and preparation method thereof
  • Benzalkonium chloride external solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prepare eight groups of benzalkonium chloride topical solutions, and the dosage of each component is shown below. According to the components and dosage of the AH group below, add benzalkonium chloride to the pH buffer solution and stir to dissolve, then add the coolant and the penetration enhancer in sequence, stir to dissolve, and finally add the thickener and stir until it becomes clear Solution, stand still, get it.

[0027] Table 1 Eight groups of benzalkonium chloride topical solutions

[0028]

[0029]

Embodiment 2

[0030] Example 2 Evaluation of antibacterial effect

[0031] In this example, the antibacterial effect of the benzalkonium chloride external solution obtained in the example of the present invention was measured by the paper agar diffusion method.

[0032] 1. Preparation of antibacterial tablets: Take a dry sterile filter paper sheet with a diameter of 9cm, drop 0.5ml of benzalkonium chloride topical solution-3 in the center of the filter paper sheet, place the filter paper sheet in a clean sterile plate, and dry it naturally at room temperature. Use; make at least 9 pieces of such antibacterial tablets as samples. For negative photos, take a dry sterile filter paper sheet, drop 0.5 ml of sterilized water into the center of the filter paper sheet, and dry for later use; in this way, make at least 3 antibacterial tablets.

[0033] 2. Preparation of stained plates: three types of bacteria, including representative Gram-positive bacteria (Staphylococcus aureus) and two Gram-negative ba...

Embodiment 3

[0040] Example 3 Evaluation of clinical effects

[0041] 1. General information

[0042] gender

70 males, 74 females, 144 cases in total

age

1-10 years old: 33 cases; 11-20 years old: 38 cases; 21-30 years old: 36 cases; 31-40 years old: 37 cases

Case

49 cases of subcutaneous abscess of limbs; 45 cases of surgical incision infection; 50 cases of trauma infection

[0043] 2. Treatment method: clean up the wound, randomly assign 9 groups of patients, 16 patients in each group, use the AH group benzalkonium chloride solution in Example 1 to clean the affected area in eight groups, and the other group of patients with domestic marketed Common benzalkonium chloride lotion was used for cleaning as a control. After washing, the dressing is changed and carefully bandaged with sterile gauze. This treatment was carried out twice a day, and the treatment effect was evaluated for 7 days.

[0044] 3. Evaluation criteria

[0045] Significant effect: the swelling of the affected area is ...

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Abstract

The invention discloses a benzalkonium chloride external solution and a preparation method thereof. The benzalkonium chloride external solution comprises the following components in percentage by mass: 0.06 to 0.12 percent of benzalkonium chloride, 2.0 to 6.5 percent of a permeation enhancer, 0.5 to 2.0 percent of a tackifier, 0.1 to 6.0 percent of a cooling agent and the balance of a pH buffer solution. The benzalkonium chloride external solution can effectively improve absorption of the benzalkonium chloride effective component on an affected part, completely guarantees the antibacterial effect of the benzalkonium chloride, avoids organ toxicity and skin allergic reaction caused by the benzalkonium chloride and improves the problems that the traditional benzalkonium chloride external preparation is insufficient to absorb and has an unstable antibacterial effect; furthermore, the preparation method is simple, the benzalkonium chloride external solution can be produced without specialequipment, and a good application prospect is achieved.

Description

Technical field [0001] The invention belongs to the field of pharmacy. More specifically, the invention relates to a benzalkonium chloride external solution with high skin absorption, low irritation and good antibacterial stability and a preparation method thereof. Background technique [0002] Benzalkonium chloride is a cationic surfactant, a non-oxidizing bactericide, with a broad-spectrum, high-efficiency bactericidal and algae-killing ability, can effectively control the growth of bacteria and algae and slime growth in water, and has good slime peeling It has a certain degree of dispersion and penetration, as well as a certain degree of oil removal, deodorization and corrosion inhibition. This product is very soluble in water or ethanol, slightly soluble in ether, and belongs to the class of disinfectant and antiseptic. Benzalkonium chloride dissociates into cationic active groups in an aqueous solution. It has cleansing and bactericidal effects. It is used for skin disinfec...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/14A61K47/38A61P31/04
CPCA61K9/0014A61K9/08A61K31/14A61K47/38A61P31/04
Inventor 陈雪君吴淑铭
Owner HAINAN HUALON PHARM
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