Method for splitting and measuring enantiomer of chiral pesticide benalaxyl through ultra-performance convergence chromatography-tandem mass-spectrometric technique

Abstract

The invention belongs to the field of analytical chemistry and the technical field of determination of pesticide residues, particularly relates to a method for splitting and measuring enantiomer of achiral pesticide benalaxyl through the ultra-performance convergence chromatography-tandem mass-spectrometric technique, and relates to a method for splitting and quantifying raceme of the chiral pesticide. The method uses a QuEChERs method to extract benalaxyl in tobacco, cereals and dried fruits, and the enantiomer of the chiral pesticide benalaxyl is detected through the combination of convergence chromatographic chiral stationary phase and triple quadrupole tandem mass spectrum. The convergence chromatography is used for the first time to rapidly chirally separate the benalaxyl, and the sensitivity is high. The supercritical CO2 is taken as a mobile phase, a large number of organic solvents are saved in use, and the method is green and environmentally friendly.

Description

technical field [0001] The invention belongs to the field of analytical chemistry and the technical field of pesticide residue detection, and specifically relates to a method for splitting and measuring the enantiomers of the chiral pesticide benalaxyl by ultra-high-efficiency convergence chromatography-tandem mass spectrometry, and relates to the racemization of the chiral pesticide Body separation and quantification methods. Background technique [0002] The enantiomers of chiral pesticides often have significantly different digestion and fate in the environment. That is, the enantiomers of chiral pesticides may have huge differences in many aspects such as activity, toxicity, absorption, metabolism, and degradation in the natural environment and organisms. [0003] Chiral analysis is a powerful tool that can help people detect and deeply understand the biochemical impact process of chiral pesticides on the environment. A comprehensive and in-depth understanding of chiral...

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Problems solved by technology

Hou Jingguo et al [Analytical Chemistry, 2006, 11(34), 1424-1528] separated a group of enantiomers of benalaxyl by high performance liquid chromatography using a chiral chromatographic column, but the synthesis of the chiral column is cumbersome and the separation time is cumbersome. Long, consumes a lot of organic solvent

Feng Shuoli et al [Zhejiang University of Technology, master's thesis] and others adopted a chromatographic column to separate a group of enantiomers of benalaxyl by supercritical fluid chromatography, but the separation time was long

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