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Compound bacteriostatic agent as well as preparation method and application thereof

A compound antibacterial and bacteriostatic agent technology, applied in the direction of botanical equipment and methods, applications, biocides, etc., can solve the problems that have not been seen in related reports

Active Publication Date: 2018-08-24
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the basis of the above research results, this application has obtained a new type of compound antibacterial agent, which has good antibacterial properties. In this application, a compound in the bismuth subnitrate system——Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 , and combine it with Ag / AgCl to synthesize a molecular formula of Ag / AgCl / Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 compound antibacterial agent, the above technical content has not seen relevant reports in the prior art

Method used

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  • Compound bacteriostatic agent as well as preparation method and application thereof
  • Compound bacteriostatic agent as well as preparation method and application thereof
  • Compound bacteriostatic agent as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The molecular formula of the novel compound antibacterial agent involved in this embodiment is Ag / AgCl / Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54, the property is gray powder, odorless, has good visible light response ability in the visible light range (390-760nm); has good inhibitory ability to bacteria such as Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella, and its concentration is 35μg / mL can completely inhibit the concentration of 5 × 10 5 Growth of bacteria in cfu / mL bacterial suspension.

[0023] The composite antibacterial agent involved in the present embodiment can be known through X-ray powder diffractometer (XRD) identification (specifically as figure 1 Shown), there are three kinds of phase Bi in this compound antibacterial agent 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 , AgCl and Ag, where Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 is the main phase.

[0024] The compound bacteriostatic agent that present embodiment relates to can know (r...

Embodiment 2

[0026] The molecular formula that present embodiment relates to is Ag / AgCl / Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 The compound bacteriostat preparation method comprises the following steps:

[0027] (1) Preparation of BiOCl

[0028] ①To 0.05-0.1mol bismuth oxide (Bi 2 o 3 ) was added dropwise 10-40mL nitric acid (HNO 3 ), stir until completely dissolved to form a transparent solution, and then add ammonia water (NH 3 ·H 2 O) to adjust the pH value to 3-5, so that a white precipitate appears in the transparent solution to form a suspension;

[0029] ②Put the suspension at 40-80°C under temperature control and continue magnetic stirring for 10-30 minutes to form a white jelly. 2 h 5 OH) After centrifuging and washing the white jelly for three times, drying the white jelly at a temperature of 30-50° C. for 24 hours, and collecting a white powder of BiOCl;

[0030] (2) Preparation of Ag / AgCl / Bi by impregnation method 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54

[0031] ① Dissolv...

Embodiment 3

[0043] This embodiment is to the Ag / AgCl / Bi prepared in embodiment 2 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 The bacteriostasis performance of compound antibacterial agent is tested (results such as image 3 shown), the test sample (Ag / AgCl / Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 Composite bacteriostatic agent) has bacterial growth when concentration is 25 μ g / mL, and when concentration is 35 μ g / mL, the growth of bacteria is completely inhibited, so the minimum inhibitory concentration of test sample is 35 μ g / mL.

[0044] The specific test methods and steps are as follows:

[0045] (1) Put the instruments required for the experiment into the ultra-clean workbench after cleaning, high-temperature sterilization, and drying, and turn on the ultraviolet lamp to sterilize for 30 minutes;

[0046] (2) Ag / AgCl / Bi was mixed with deionized water 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 The compound antibacterial agent (hereinafter referred to as the test sample) was diluted to the concentra...

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Abstract

The invention belongs to the technical field of composites and preparation and relates to a novel compound bacteriostatic agent as well as a preparation method and an application thereof. The compoundbacteriostatic agent has the molecular formula of Ag / AgCl / Bi6O4.46(OH)3.54(NO3)5.54, is grey powder and odorless, has good visible-light response capacity and bacteriostatic ability and can have a better inhibition function on bacteria such as escherichia coli, staphylococcus aureus, salmonella and the like. Single-component Bi6O4.46(OH)3.54(NO3)5.54 is synthesized with a BiOCl conversion methodfor the first time and is bound with Ag / AgCl, and the novel bacteriostatic agent with the molecular formula of Ag / AgCl / Bi6O4.46(OH)3.54(NO3)5.54 is obtained. The compound bacteriostatic agent has unique chemical composition and good antibacterial effect, and the preparation method is scientific, has simple preparation process, is low in preparation cost and has good application prospects and market values.

Description

Technical field: [0001] The invention belongs to the technical field of composite materials and preparation, and relates to a novel composite antibacterial agent and its preparation method and application. The molecular formula of the composite antibacterial agent is Ag / AgCl / Bi 6 o 4.46 (OH) 3.54 (NO 3 ) 5.54 , can play a better inhibitory effect on Escherichia coli, Staphylococcus aureus, Salmonella and other bacteria. Background technique: [0002] Bacteriostatic agents are substances that inhibit the growth of bacteria. Bacteriostats in the prior art are roughly divided into three categories: inorganic, organic, and natural. Natural bacteriostats are limited by raw materials and processing conditions, and cannot achieve large-scale market production; although organic bacteriostats have It has the advantages of fast sterilization speed and wide antibacterial range, but there are problems such as poor heat resistance, easy oozing, toxic leachate, and short service life...

Claims

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Application Information

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IPC IPC(8): A01N59/16A01P1/00A61L2/08A61L2/23
CPCA61L2/084A61L2/23A01N59/16
Inventor 赵梅董立峰候小雪房玉双张浩王雨洋
Owner QINGDAO UNIV OF SCI & TECH
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