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Cyclic lipopeptide nutritional chewable tablet and preparation method thereof

A technology of cyclolipopeptide and chewable tablets, which is applied in the field of food processing, can solve the problems of restricting the application of rapeseed meal, affecting the palatability or growth and development of animals, etc., and achieve the goal of improving bioavailability, being easy to carry and transport, and convenient to eat Effect

Inactive Publication Date: 2018-09-04
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anti-nutritional factors such as glucosinolates (glucosinolates), sinapine, phytic acid, and tannins in rapeseed meal will affect the palatability or growth of animals, which limits the application of rapeseed meal in the food and feed industry

Method used

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  • Cyclic lipopeptide nutritional chewable tablet and preparation method thereof
  • Cyclic lipopeptide nutritional chewable tablet and preparation method thereof
  • Cyclic lipopeptide nutritional chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Methylotrophic Bacillus (Bacillus methylotrophicus) was expanded in seed medium. Take 5g of rapeseed meal and 0.25g of spent molasses, add 5mL of water and 0.5g of inorganic salt solution, mix well, add 0.1mL of Bacillus methylotrophicus seed liquid after expanding cultivation, and ferment at 25°C for 24h . After fermentation, add 25 mL of deionized water to soak for half an hour, add dropwise 6 mol / L sodium hydroxide to adjust the pH of the extract to 8.0, centrifuge, and collect the supernatant. Add 6 mol / L hydrochloric acid to the supernatant to adjust the pH to 2.0, let it stand for 30 minutes and then centrifuge to collect the precipitate. 0.1mol / L NaNO for precipitation 3 Washing 3 times, then washing 3 times with deionized water, centrifuging to collect the precipitate, freeze-drying to obtain the cyclolipopeptide product. Take 10 parts of cyclolipopeptide powder according to the number of parts by mass, add 80 parts of nutrients (skimmed milk powder and dextr...

Embodiment 2

[0035] Methylotrophic Bacillus (Bacillus methylotrophicus) was expanded in seed medium. Take 25g of rapeseed meal and 3.75g of spent molasses, add 25mL of water and 2.5g of inorganic salt solution, mix well, add 2.5mL of Bacillus methylotrophicus seed liquid after expanding cultivation, and ferment at 32°C for 48h . After the fermentation, add 375mL deionized water to soak for half an hour, add dropwise 6mol / L sodium hydroxide to adjust the pH of the extract to 8.0, centrifuge, and collect the supernatant. Add 6 mol / L hydrochloric acid to the supernatant to adjust the pH to 2.0, let it stand for 30 minutes and then centrifuge to collect the precipitate. 0.1mol / L NaNO for precipitation 3Washing 3 times, then washing 3 times with deionized water, centrifuging to collect the precipitate, freeze-drying to obtain the cyclolipopeptide product. Take 30 parts of cyclolipopeptide powder according to the mass parts, add 30 parts of nutrients (skimmed milk powder and dextrin are mixed...

Embodiment 3

[0037] Methylotrophic Bacillus (Bacillus methylotrophicus) was expanded in seed medium. Take 15g of rapeseed meal and 1.5g of spent molasses, add 15mL of water and 1.5g of inorganic salt solution, mix well, add 0.99mL of microbial seed liquid, and ferment at 28°C for 36h. After the fermentation, add 150mL deionized water to soak for half an hour, add dropwise 6mol / L sodium hydroxide to adjust the pH of the extract to 8.0, centrifuge, and collect the supernatant. Add 6 mol / L hydrochloric acid to the supernatant to adjust the pH to 2.0, let it stand for 30 minutes and then centrifuge to collect the precipitate. 0.1mol / L NaNO for precipitation 3 Washing 3 times, then washing 3 times with deionized water, centrifuging to collect the precipitate, freeze-drying to obtain the cyclolipopeptide product. Take 20 parts of cyclolipopeptide powder according to the mass parts, add 60 parts of nutritional substances (skimmed milk powder and dextrin are mixed in a mass ratio of 3:1), add fl...

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Abstract

The present invention discloses a cyclic lipopeptide nutritional chewable tablet and a preparation method thereof, and belongs to the technical field of food processing. The cyclic lipopeptide nutritional chewable tablet comprises the following ingredients in parts by mass: 10-30 parts of cyclic lipopeptide powder, 30-80 parts of nutrients, 5-15 parts of a flavoring agent, 1-5 parts of a binder and 0.3-1 part of a lubricant. The nutrients are skim milk powder and dextrin (at a mass percentage of 2:1 to 5:1). The preparation method comprises the following steps: the cyclic lipopeptide powder used as a main functional ingredient and the other auxiliary materials are prepared according to a certain ratio; and soft material preparing, granulating, tableting and sterilizing are conducted to prepare the cyclic lipopeptide nutritional chewable tablet. The chewable tablet is comprehensive in the nutrients, has multiple health-care effects and is convenient to eat and carry, sour, sweet, tastyand suitable for various people.

Description

technical field [0001] The invention belongs to the technical field of food processing and relates to functional health food processing, in particular to a cyclolipopeptide nutritional chewable tablet and a preparation method thereof. Background technique [0002] Cyclic lipopeptide is a secondary metabolite produced by Gram-positive bacillus through the non-ribosomal synthesis pathway, and its molecule consists of a fatty acid chain containing 13-19 carbons and a peptide chain containing 7-10 amino acids. Composition, the amino acid and the hydroxyl or amino group on the fatty acid chain are combined with a lactone or amide bond to form a cyclic lipopeptide. Existing studies have shown that cyclolipopeptide has the functions of antitumor, antibacterial, improving immunity and promoting human health. [0003] my country is the largest rapeseed meal producer in the world. In 2011, my country's rapeseed meal output was 8.95 million tons, accounting for 25% of the global rapes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/18A23L33/10A23L33/125A23L29/30A23L29/00A23P10/28C12P21/04C12R1/07
CPCA23V2002/00A23L29/03A23L29/30A23L33/10A23L33/125A23L33/18A23P10/28C12P21/00A23V2200/308A23V2200/324A23V2200/30A23V2250/55A23V2200/202
Inventor 代春华何荣海任晓锋黄六容马海乐
Owner JIANGSU UNIV
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