Synthetic process of sulfamide

Abstract

The invention discloses a synthesis process of sulfamide. The process uses a self-priming internal circulation pressure reactor instead of a commonly used ordinary reactor as an amination kettle, pumps petroleum ether into the amination kettle, vacuumizes, passes through ammonia, and adds dropwise pre-cooled to -10°C Sulfuryl chloride and petroleum ether mixture, after the dropwise addition, continue to pass ammonia gas until the pressure in the amination tank is stable and the temperature does not rise, the amination reaction is completed, and then through static stratification, hydrolysis, dissolution, filtration, refining, Crystallization, drying and other steps to obtain the finished product of sulfamide. The present invention ends the long-standing requirement that ammonia refrigerator equipment must be used in the production of sulfamide from the structure of process equipment. The refrigerating coil installed in the self-priming internal circulation pressure reactor makes the reaction temperature reach an effective steady state, shortens the reaction time, thereby shortening the production cycle of sulfamide, maximizing the satisfaction of production needs, reducing energy consumption and reducing ammonia Exhaust gas emission increases the utilization rate of ammonia from the original 50% to over 95%.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a synthesis process of sulfamide. Background technique [0002] Sulfuramide is an intermediate produced by the side chain of famotidine, and is a traditional pharmaceutical intermediate product. At present, sulfuryl chloride and liquid ammonia are mainly used in industry to acylate, and then hydrolyzed with hydrochloric acid to obtain sulphamide products. In the process of acylation synthesis, the temperature requirements are extremely strict, and the utilization rate of ammonia in the reaction process is low. The industry has been using external circulation ammonia refrigerators to recover and reuse unreacted ammonia gas, which requires large energy consumption and pollution. The environment is large, so how to develop a sulfamide production process with leading quality and environmentally friendly technology is imperative. Contents of the invention [...

AI Technical Summary

Problems solved by technology

In the process of acylation synthesis, the temperature requirements are extremely strict, and the utilization rate of ammonia in the reaction process is low. The industry has been using external circulation ammonia refrigerators to recover and reuse unreacted ammonia gas, which requires large energy consumption and pollution. The environment is large, so how to develop a sulfamide production process with leading quality and environmentally friendly technology is imperative

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