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Pyrazinamide tablet and preparation method thereof

A technology of pyrazinamide tablets and pyrazinamide, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Efficiency, the effect of improving yield and tableting speed

Inactive Publication Date: 2018-09-18
JIANGSU SIHUAN BIOENGINEERING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to disclose a kind of pyrazinamide tablet and preparation method thereof, to overcome the defect that the pyrazinamide tablet in the prior art exists in the preparation process of easy splitting, tablet is not shaped, to reduce the pyrazinamide tablet Yield, and increase tablet speed to increase production efficiency of pyrazinamide tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pyrazinamide tablet, in parts by weight, comprising: 250 parts of pyrazinamide, 24 parts of filler, 12 parts of sucrose, 18 parts of microcrystalline cellulose, 8 parts of hydroxypropyl cellulose, and 20 parts of 18% starch for pulping Parts, 2 parts polysorbate-80, 1 part lubricant, 4 parts sodium carboxymethyl starch, 1 part adhesive.

[0023] Specifically, in this embodiment, the lubricant is one or a mixture of two or more of magnesium stearate, sodium stearate fumarate, calcium stearate, and zinc stearate in any ratio, and preferably It is magnesium stearate. The filler is one or a mixture of two or more of starch, dextrin, lactose, and calcium carbonate in any ratio; further, the filler is a mixture of starch and dextrin, and specifically the weight parts of starch and dextrin equal. The binder is one of gelatin solution, povidone K30 aqueous solution, and sucrose solution, or a mixture of two or more in any ratio.

Embodiment 2

[0025] This embodiment discloses a preparation method of pyrazinamide tablets. The preparation method adopts the prescription amount described in Example 1, and includes the following steps:

[0026] S1. After pulverizing pyrazinamide and sucrose, sieving with an 80 mesh screen, and using 80 mesh for fillers, microcrystalline cellulose, hydroxypropyl cellulose, lubricants (such as magnesium stearate), and sodium carboxymethyl starch Sieve through a sieve, put the above-mentioned components after sieving into a wet granulator and dry-mix for 10-20 minutes, then add polysorbate-80 and 18% starch for pulping, stir, mix and granulate to obtain a mixed powder;

[0027] S2. Place the prepared mixed powder in a boiling dryer, boil and dry at 70°C~80°C for 20-40 minutes, sieve the dried mixed powder with a 100-mesh screen, and then add lubricant and carboxymethyl Sodium starch, mix for 15 minutes, then transfer to wet granulator;

[0028] S3. Spray the binder into the wet mixing granulator....

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Abstract

The invention provides a pyrazinamide tablet and a preparation method thereof. The pyrazinamide tablet is prepared from the following components in parts by weight: 250 parts of pyrazinamide, 24 partsof filler, 12 parts of saccharose, 18 parts of microcrystalline cellulose, 8 parts of hydroxypropylcellulose, 20 parts of 18% pulp starch, 2 parts of polysorbate-80, 1 part of lubricant, 4 parts of sodium carboxymethyl starch, and 1 part of binding agent. The pyrazinamide tablet prepared according to the preparation method overcomes the defects that in the prior art, the pyrazinamide tablet is prone to crushing in the preparation process and the tablet is out of shape, the finished product ratio and the tabletting speed of the pyrazinamide tablet are improved, and the production efficiency ofthe pyrazinamide tablet is remarkably improved.

Description

Technical field [0001] The invention relates to the technical field of pharmacy, in particular to a pyrazinamide tablet and a preparation method thereof. Background technique [0002] Pyrazinamide tablets can effectively inhibit mycobacteria and are usually used in combination with other anti-tuberculosis drugs (such as streptomycin, isoniazid, rifampicin and ethambutol) to treat tuberculosis. [0003] The Chinese invention patent with publication number CN1629147A provides the preparation method of pyrazinamide bulk medicine and pyrazinamide tablets. Pyrazinamide tablets contain the following components per 100,000 tablets: pyrazinamide 20-30kg, starch 5.2-7.8kg, Microcrystalline cellulose 1.2~1.8kg, powdered sugar 0.8~1.2kg, 10% starch slurry appropriate amount, magnesium stearate (additional) appropriate amount, talcum powder (additional) appropriate amount; the main material pyrazinamide is crushed, and the auxiliary material starch, micro The crystalline cellulose and powdere...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4965A61K47/38A61K47/42A61P31/06
CPCA61K9/2059A61K9/2063A61K31/4965A61P31/06
Inventor 丁月萍沈振宇宋紫薇江永红
Owner JIANGSU SIHUAN BIOENGINEERING PHARM CO LTD
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