Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chitosan superfine fiber systems

A technology of chitosan and chitosan salt, which is applied in fiber treatment, fiber chemical characteristics, melt spinning, etc., can solve the problem of reducing the functional ability of polymers to interact with cells, and achieve the effect of promoting hemorrhage control

Pending Publication Date: 2018-09-28
TRICOL BIOMEDICAL INC
View PDF48 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually high levels of crosslinking are undesirable in bioactive substances because crosslinking reduces the functional ability of the polymer to interact with cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chitosan superfine fiber systems
  • Chitosan superfine fiber systems
  • Chitosan superfine fiber systems

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1 details results from pilot scale experiments. Subsequent evaluations from Formulation 25 had a basis weight of 17.6 g / cm 2 Fiber samples of: a) tissue attachment and stability (see Example 2), and b) hemostatic efficacy in an anticoagulated porcine injury model of gastrointestinal bleeding (see Example 3).

[0078] Example 1. Formulations 25-30, Example Fiber Tests: On Production Scale Spinning on FE 1.1 (FibeRio Technology Corporation)

[0079] Tables 1, 2 and 3 demonstrate that a chitosan-based solution (with a polymer content of 89% w / w chitosan and 11% w / w polyethylene oxide (400 kDa)) was tested on a pilot scale machine (FE1. 1) Spinnability under centrifugal spinning. One polyvinylpyrrolidone (PVP) formulation (#30) was not successfully spun. The typical flow rate of the chitosan solution from FE1.1 during spinning is about 5.0 g / min, the fastest flow rate is about 8.0 g / min from the spinneret. Since the highest expected flow rate specified for FE1...

Embodiment 2

[0088] Example 2. In vitro tests of ultrafine chitosan fibers for tissue adhesion, foldability and dissolution resistance in harsh biological environments such as the stomach

[0089] INTRODUCTION: Tissue adhesion, foldability, and resistance to dissolution in harsh biological environments such as the stomach are highly desirable features of ultrafine chitosan fiber nonwoven matrices intended for medical applications, which Includes external wound care, internal implantation, drug delivery, hemostatic applications, and delivery through endoscopes or catheters for minimally invasive wound care and hemostasis.

[0090] a) The dissolution resistance to synthetic gastric juice at 37°C was studied as follows. Synthetic gastric juice was prepared according to a formulation of pepsin (1.6 g), NaCl (1 g), water (500 ml), all added to a Nalgene LDPE 1000 ml bottle and mixed. The acidity was adjusted to pH 3-4 using Millipore pH 0-14 Universal Indicator Strips and 3.0M HCl was added dr...

Embodiment 3

[0098] Example 3. Porcine injury model of hemostasis, manual application in gastric injury to evaluate the efficacy of chitosan-based ultrafine nonwoven fibers: a) 15 minutes after application; and b) closed and evaluated by gastroscopy at 180 minutes Evaluation of hemostasis in the stomach

[0099] Foreword: Application of observations and successful bleeding control of arterial bleeding in the anticoagulated bleeding model described in this example not only demonstrates the application of the tissue-attached ultrafine chitosan fibers of the present invention in targeted wound care, bleeding and general wound care It has broad applicability for fluid loss and has also demonstrated particular suitability for fluid loss in addressable wound care, bleeding, and minimally invasive procedures, such as control of upper gastrointestinal bleeding.

[0100] Methods: All experiments were performed in accordance with the 2011 National Research Council "Guide for the Care and Use of Labo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The present chitosan-based superfine fiber invention relates to compositions, formulations, and processes that result in numerous significant advantages for the production and use of superfine fiber bioactive matrices in biomedical applications. The present invention relates to superfine, chitosan-based fibers, wherein the chitosan-based fibers have a percentage chitosan content of at least about20% w / w, and highly conformable and compliant matrices comprising such fibers, processes for their production, and related formulations. The superfine chitosan-based fibers of the invention preferablyinclude microfibers with diameter less than or equal to about 10 microns and micron and submicron fibers that are about 2 microns and less.

Description

[0001] related application [0002] This application claims priority to US Provisional Patent Application Serial No. 62 / 294,994, filed February 12, 2016, the contents of which are incorporated herein by reference in their entirety. technical field [0003] The present invention of chitosan based microfibers relates to compositions, formulations and methods leading to numerous significant advantages for the production of microfiber bioactive matrices and their use in biomedical applications . Chitosan-based microfibers of the present invention are spun from a solution composition comprising a non-volatile chitosan polymer; volatile, semi-volatile or non-volatile Acid component; optional non-volatile diluent polymer component, which assists the fiber spinning (spinning) process; optional crosslinking component, which is combined with the spun polymer after spinning and drying fiber crosslinking; and water. Low percentages (less than or equal to 5% by mass of dry fibers) of a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18C08J5/04
CPCA61L15/425A61L24/0036A61L24/08D01D1/02D01D5/18D01D10/02D01F1/02D01F9/00A61L15/28A61L2400/04A61L27/20A61L27/56A61L27/50C08L5/08A61L2430/00D01D5/08D01D5/084
Inventor B·克拉雷R·德沃拉克S·麦卡西J·玛查特
Owner TRICOL BIOMEDICAL INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com