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Magnetic polymer core-shell microspheres, preparation method and application thereof

A technology of core-shell structure and polymer, applied in the field of magnetic polymer core-shell structure microspheres and its preparation, to achieve the effect of uniform shape, good separation effect and low cost

Active Publication Date: 2021-02-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods are all based on the chemical synthesis of polymer magnetic microsphere particles, and these methods have certain limitations. In view of the increasingly wide application of polymer magnetic microspheres in daily life, especially in the field of biomedicine, It is also particularly important to continuously develop and explore new methods to prepare polymer magnetic microspheres

Method used

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  • Magnetic polymer core-shell microspheres, preparation method and application thereof
  • Magnetic polymer core-shell microspheres, preparation method and application thereof
  • Magnetic polymer core-shell microspheres, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] First weigh 4g Fe 3 o 4 Nanopowder, ground in an agate mortar for 10min. Then weigh 40g of organic matter COC particles, Fe 3 o 4 The nanopowder and COC particles are mixed evenly at 240°C, and then the mixture is extruded into a core rod, and then the core rod is placed in a hollow PMMA rod, and shrunk into a solid core rod in a vacuum drying oven to obtain an optical fiber preform. Then, the preform rod prepared above was pulled down on a drawing tower at 260° C. to draw an optical fiber, and the diameter of the obtained optical fiber was 200 μm. Take 10 cm of the above-mentioned optical fiber and heat-treat it in a furnace at 280°C for 3 minutes, then soak the heat-treated optical fiber in the organic solvent dimethylacetamide (DMAC) for 30 minutes, and repeat the soaking 3-5 times to fully remove the cladding organic matter, get coated Fe 3 o 4 The SEM image of the COC polymer microspheres of nanopowders and microspheres dispersed in dimethylacetamide figure ...

Embodiment 2

[0036] Weigh 4g NiFe 2 o 4 Nanopowder, ground in an agate mortar for 10min. Then weigh 40g of organic matter COC particles, NiFe 2 o 4 The nanopowder and COC particles are mixed evenly at 240°C, and then the mixture is extruded into a core rod, and then the core rod is placed in a hollow PMMA rod, and shrunk into a solid core rod in a vacuum drying oven to obtain an optical fiber preform. Then, the preform rod prepared above was pulled down on a drawing tower at 250° C. to make an optical fiber, and the diameter of the obtained optical fiber was 200 μm. Take 10 cm of the above-mentioned optical fiber and heat-treat it in a furnace at 280°C for 3 minutes, then soak the heat-treated optical fiber in the organic solvent dimethylacetamide (DMAC) for 30 minutes, and repeat the soaking 3-5 times to fully remove the cladding organic matter, Get Coated NiFe 2 o 4 Nanopowder COC polymer microspheres are dispersed in dimethylacetamide. After the carboxyl group is modified on the ...

Embodiment 3

[0039] Weigh 4g MnFe 2 o 4 Nanopowder, ground in an agate mortar for 10min. Then weigh 40g of organic matter COC particles, MnFe 2 o 4 The nanopowder and COC particles are uniformly mixed at 240°C, and then the mixture is extruded into a core rod, and then the core rod is placed in a hollow PC rod, and shrunk into a solid rod in a vacuum drying oven to obtain an optical fiber preform. Then, the preform rod prepared above was pulled down on a drawing tower at 245° C. to make an optical fiber, and the diameter of the obtained optical fiber was 200 μm. Take 10 cm of the above-mentioned optical fiber and heat-treat it in a furnace at 280°C for 3 minutes, then soak the heat-treated optical fiber in the organic solvent dimethylacetamide (DMAC) for 30 minutes, and repeat the soaking 3-5 times to fully remove the cladding organic matter, Get coated MnFe 2 o 4 Nanopowder COC polymer microspheres are dispersed in dimethylacetamide. After the carboxyl group is modified on the surf...

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Abstract

The invention discloses a preparation method of magnetic polymer core-shell structure microspheres, which comprises the following steps: (1) thermally mixing magnetic nanoparticles and organic particles, and then extruding them into rods; (2) putting the rods into Hollow-core optical fiber cladding, and then shrunk into a rod in a vacuum oven to make an optical fiber preform; (3) Draw the optical fiber preform into an optical fiber on a wire drawing tower; (4) Draw the optical fiber at a temperature higher than the optical fiber heat treatment at a temperature of 5°C-50°C; (5) using an organic solvent to dissolve the organic cladding of the optical fiber to obtain magnetic polymer microspheres. The invention also discloses the magnetic macromolecule core-shell structure microsphere and its application. The magnetic polymer microspheres obtained by the present invention are uniform in size and good in dispersibility, and the size of the magnetic microspheres is controllable from the micron level to the nano level, and a large number of microspheres can be prepared by drawing optical fibers, which is easy to achieve mass production; the surface modification of the magnetic microspheres After the carboxyl group, antibodies can be coupled to separate cells, and the separation effect is good.

Description

technical field [0001] The invention relates to a core-shell structure material, in particular to a magnetic polymer core-shell structure microsphere, a preparation method and application thereof. Background technique [0002] Magnetic polymer microspheres refer to a type of microsphere particles that combine organic polymer substances and inorganic magnetic particles with both polymer material properties and magnetic responsiveness. Since magnetic polymer microspheres have many excellent properties of polymer microspheres and are magnetically responsive, it can not only endow a variety of surface functional groups through a variety of different surface modification methods, but also It can be separated quickly and conveniently under the influence of the action, so it has a very wide range of applications. [0003] Among many polymer composite microspheres, polymer microspheres with carboxyl groups on the surface are widely used in biochemistry, immunoassay, RNA and DNA pur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02C12M1/00
CPCB01J13/02C12M1/00
Inventor 周时凤杜明辉叶树标唐俊州陈杰杰时琢
Owner SOUTH CHINA UNIV OF TECH