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Preparation method of a PLGA [poly(lactic-co-glycolic acid)]/bioactive glass composite degradable bone nail

A technology of bioactive glass and bioglass, which is applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of high brittleness, inactivation of protein and polypeptide drugs, and low mechanical strength, and achieve large output and simple and easy preparation process Good mechanical strength effect

Inactive Publication Date: 2018-11-02
深圳飞翔世纪生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional bioglass scaffolds generally have the disadvantages of high brittleness, low mechanical strength, and the inactivation of protein and polypeptide drugs.

Method used

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  • Preparation method of a PLGA [poly(lactic-co-glycolic acid)]/bioactive glass composite degradable bone nail
  • Preparation method of a PLGA [poly(lactic-co-glycolic acid)]/bioactive glass composite degradable bone nail
  • Preparation method of a PLGA [poly(lactic-co-glycolic acid)]/bioactive glass composite degradable bone nail

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Use sol-gel method to prepare bioactive glass, in which SiO 2 : P 2 O 5 : The mass percentage of CaO bioglass powder is: 58% silica, 6% phosphorous pentoxide, and 36% calcium oxide. Use a nano grinding machine to grind into nano-level bioactive glass;

[0027] (2) Accurately weigh 100mg of PLGA particles and dissolve them in 500μL of a mixed solution of dichloromethane and acetone (volume ratio 9:1). After the ultrasonic is completely dissolved, add 25mg of BG powder and disperse evenly, and react at 50℃. Within 24 hours, a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass is formed;

[0028] (3) Volatilize the dichloromethane and acetone in the mixed emulsion prepared in step (2) in a fume hood, wash with water, and dry, put the resulting powder into the spark plasma sintering chamber, and apply a shaft of 50MPa at both ends When the pressure in the sintering chamber reaches 60Pa, start heating. The heating rate is 30℃ / min. When the temperature ...

Embodiment 2

[0030] (1) Use sol-gel method to prepare bioactive glass, in which SiO 2 : P 2 O 5 :The mass percentage of CaO bioglass powder is: 58% silica, 10% phosphorus pentoxide, and 32% calcium oxide. Use a nano grinding machine to grind into nano-level bioactive glass;

[0031] (2) Accurately weigh 100mg of PLGA particles and dissolve them in 500μL of a mixed solution of dichloromethane and acetone (volume ratio 9:1). After the ultrasonic is completely dissolved, add 25mg of BG powder and disperse evenly, and react at 50℃. Within 24 hours, a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass is formed;

[0032] (3) Volatilize the dichloromethane and acetone in the mixed emulsion prepared in step (2) in a fume hood, wash with water, and dry, put the resulting powder into the spark plasma sintering chamber, and apply a shaft of 50MPa at both ends When the pressure in the sintering chamber reaches 60Pa, start heating. The heating rate is 30℃ / min. When the temperature r...

Embodiment 3

[0034] (1) Use sol-gel method to prepare bioactive glass, in which SiO 2 : P 2 O 5 : The mass percentage of CaO bioglass powder is: 58% silica, 15% phosphorus pentoxide, and 27% calcium oxide. Use a nano grinding machine to grind into nano-level bioactive glass;

[0035] (2) Accurately weigh 100mg of PLGA particles and dissolve them in 500μL of a mixed solution of dichloromethane and acetone (volume ratio 9:1). After the ultrasonic is completely dissolved, add 25mg of BG powder and disperse evenly, and react at 50℃. Within 24 hours, a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass is formed;

[0036] Volatilize the dichloromethane and acetone in the mixed emulsion prepared in step (2) in a fume hood, wash with water, and dry, put the obtained powder into the spark plasma sintering chamber, and apply an axial pressure of 50MPa at both ends, Vacuum and start heating when the pressure in the sintering chamber reaches 60 Pa. The heating rate is 30°C / min. Whe...

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Abstract

The invention provides a preparation method of a PLGA [poly(lactic-co-glycolic acid)] / bioactive glass composite degradable bone nail. The preparation method comprises the following steps: (1) dissolving polylactic acid-glycolic acid copolymer particles into an organic solvent to prepare an oil-phase solution of poly(light glycolic acid); (2) adding bioactive glass powder into the oil-phase solution to form a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass; (3) volatilizing the organic solvent in the mixed emulsion prepared in the step (2), washing with water, drying and placing the obtained powder in a discharge plasma sintering cavity for sintering. The biodegradable bone nail prepared by the method has high biocompatibility, high mechanical strength and high bioavailability. Through addition of the bioactive glass, an acidic environment generated in the degradation process of a polylactic acid-glycolic acid copolymer can be neutralized, so that the change ofpH value of the degradation solution of the polylactic acid-glycolic acid copolymer tends to be stable. The preparation method has the advantages of simple process, low cost and safer production industry.

Description

Technical field [0001] The invention relates to the field of biological materials, in particular to a preparation method of a PLGA / bioactive glass composite degradable bone nail. Background technique [0002] Bone defect has always been a medical problem. At present, the ideal method is autologous or allogeneic bone transplantation. Autologous bone transplantation is widely regarded as the "gold standard" for measuring bone graft fusion. Although autologous bone transplantation has many advantages, such as adapting to the regeneration of surrounding bone tissue, there are still some disadvantages, such as limited donors for autologous bone transplantation, secondary trauma, increased surgical difficulty, and a certain failure rate. Allogeneic bone sometimes fails to stimulate osteogenesis and often induces adverse reactions. Research on new types of bone replacement products has become a common problem faced by medical workers and materials workers. [0003] Poly(lactic-co-glycol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/10A61L27/12A61L27/50
CPCA61L27/18A61L27/10A61L27/12A61L27/50A61L2430/02C08L67/04
Inventor 董毅翔刘宏飞
Owner 深圳飞翔世纪生物科技有限公司
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