Preparation method of a PLGA [poly(lactic-co-glycolic acid)]/bioactive glass composite degradable bone nail
A technology of bioactive glass and bioglass, which is applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of high brittleness, inactivation of protein and polypeptide drugs, and low mechanical strength, and achieve large output and simple and easy preparation process Good mechanical strength effect
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Embodiment 1
[0026] (1) Use sol-gel method to prepare bioactive glass, in which SiO 2 : P 2 O 5 : The mass percentage of CaO bioglass powder is: 58% silica, 6% phosphorous pentoxide, and 36% calcium oxide. Use a nano grinding machine to grind into nano-level bioactive glass;
[0027] (2) Accurately weigh 100mg of PLGA particles and dissolve them in 500μL of a mixed solution of dichloromethane and acetone (volume ratio 9:1). After the ultrasonic is completely dissolved, add 25mg of BG powder and disperse evenly, and react at 50℃. Within 24 hours, a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass is formed;
[0028] (3) Volatilize the dichloromethane and acetone in the mixed emulsion prepared in step (2) in a fume hood, wash with water, and dry, put the resulting powder into the spark plasma sintering chamber, and apply a shaft of 50MPa at both ends When the pressure in the sintering chamber reaches 60Pa, start heating. The heating rate is 30℃ / min. When the temperature ...
Embodiment 2
[0030] (1) Use sol-gel method to prepare bioactive glass, in which SiO 2 : P 2 O 5 :The mass percentage of CaO bioglass powder is: 58% silica, 10% phosphorus pentoxide, and 32% calcium oxide. Use a nano grinding machine to grind into nano-level bioactive glass;
[0031] (2) Accurately weigh 100mg of PLGA particles and dissolve them in 500μL of a mixed solution of dichloromethane and acetone (volume ratio 9:1). After the ultrasonic is completely dissolved, add 25mg of BG powder and disperse evenly, and react at 50℃. Within 24 hours, a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass is formed;
[0032] (3) Volatilize the dichloromethane and acetone in the mixed emulsion prepared in step (2) in a fume hood, wash with water, and dry, put the resulting powder into the spark plasma sintering chamber, and apply a shaft of 50MPa at both ends When the pressure in the sintering chamber reaches 60Pa, start heating. The heating rate is 30℃ / min. When the temperature r...
Embodiment 3
[0034] (1) Use sol-gel method to prepare bioactive glass, in which SiO 2 : P 2 O 5 : The mass percentage of CaO bioglass powder is: 58% silica, 15% phosphorus pentoxide, and 27% calcium oxide. Use a nano grinding machine to grind into nano-level bioactive glass;
[0035] (2) Accurately weigh 100mg of PLGA particles and dissolve them in 500μL of a mixed solution of dichloromethane and acetone (volume ratio 9:1). After the ultrasonic is completely dissolved, add 25mg of BG powder and disperse evenly, and react at 50℃. Within 24 hours, a mixed emulsion of polylactic acid-glycolic acid copolymer / bioactive glass is formed;
[0036] Volatilize the dichloromethane and acetone in the mixed emulsion prepared in step (2) in a fume hood, wash with water, and dry, put the obtained powder into the spark plasma sintering chamber, and apply an axial pressure of 50MPa at both ends, Vacuum and start heating when the pressure in the sintering chamber reaches 60 Pa. The heating rate is 30°C / min. Whe...
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