Bio-active glass ceramic and preparation method thereof

Abstract

The invention discloses bio-active glass ceramic and a preparation method thereof. The bio-active glass ceramic includes the following raw materials, by weight, 50-70 parts of sodium oxide, 12-25 parts of zirconium oxide, 5-16 parts of phosphorus pentoxide, 6-12 parts of sodium fluoride, 4-14 parts of strontium oxide, 16-28 parts of silicon dioxide, 10-40 parts of zinc oxide and 3-10 parts of ammonium polyacrylate. The preparation method includes the following steps: weighing the raw materials according to the weight parts, mixing the raw materials, placing the raw materials in a crucible and heating the crucible, maintaining the temperature at 1500-1600 DEG C for 1-2 h, rapidly-cooling the mixture to obtain a frit, crushing the frit into glass powder, smelting the glass powder in the crucible at 1050-1100 DEG C, and naturally cooling the glass to obtain the bio-active glass ceramic. The bio-active glass ceramic can actively participate in bio-reactions and induce growth of bone tissue being contacted with the glass ceramic around the bio-active glass ceramic to form continuous bone materials.

Description

technical field

[0001] The invention belongs to the field of bioactive materials, and in particular relates to a preparation method of a bioactive glass-ceramic material used for bone defect repair. Background technique

[0002] Skeletal lesion is a clinical common disease and frequently-occurring disease. Through the development of bone repair and bone substitute materials, it can help patients repair defective or missing bone tissue and better restore the function of human tissue. In bone tissue engineering, an ideal repair material should meet the following conditions: good biocompatibility, biodegradability, plasticity, three-dimensional porous and interconnected pore structure and certain mechanical strength. In the field of bone defect repair research, there is an urgent need for scaffold materials that match the mechanical strength of human bone, have good cell compatibility, and promote the growth of new bone tissue.

[0003] Bioactive materials are materials used ...

Examples

Embodiment 1

[0025] A bioactive glass-ceramic, comprising the following raw materials in parts by weight: 58 parts of sodium oxide, 18 parts of zirconia, 12 parts of phosphorus pentoxide, 8 parts of sodium fluoride, 8 parts of strontium oxide, 22 parts of silicon dioxide, 30 parts of zinc, 6 parts of ammonium polyacrylate.

[0026] Wherein, the particle diameter of silicon dioxide is 250nm, the particle diameter of zinc oxide is 500nm, and the relative molecular mass of ammonium polyacrylate is 1000.

[0027] Prepare the preparation method of above-mentioned bioactive glass-ceramic, comprise the following steps:

[0028] (1) Weigh sodium oxide, zirconium oxide, phosphorus pentoxide, sodium fluoride, strontium oxide, silicon dioxide, zinc oxide and ammonium polyacrylate in parts by weight, mix and add in the orange pot;

[0029] (2) Heating the crucible, keeping it at 1500°C for 2 hours, quenching to form a frit, and crushing into glass powder;

[0030] (3) Melt the glass powder in a citr...

Embodiment 2

[0033] A bioactive glass-ceramic, comprising the following raw materials in parts by weight: 50 parts of sodium oxide, 12 parts of zirconia, 5 parts of phosphorus pentoxide, 6 parts of sodium fluoride, 4 parts of strontium oxide, 16 parts of silicon dioxide, 10 parts of zinc, 3 parts of ammonium polyacrylate.

[0034] Wherein, the particle diameter of silicon dioxide is 350nm, the particle diameter of zinc oxide is 800nm, and the relative molecular mass of ammonium polyacrylate is 5000.

[0035] Prepare the preparation method of above-mentioned bioactive glass-ceramic, comprise the following steps:

[0036] (1) Weigh sodium oxide, zirconium oxide, phosphorus pentoxide, sodium fluoride, strontium oxide, silicon dioxide, zinc oxide and ammonium polyacrylate in parts by weight, mix and add in the orange pot;

[0037] (2) Heating the crucible, holding it at 1600°C for 1 hour, quenching to form a frit, and crushing into glass powder;

[0038] (3) Melt the glass powder in a citrus...

Embodiment 3

[0041] A bioactive glass-ceramic, comprising the following raw materials in parts by weight: 70 parts of sodium oxide, 25 parts of zirconia, 16 parts of phosphorus pentoxide, 12 parts of sodium fluoride, 14 parts of strontium oxide, 28 parts of silicon dioxide, 40 parts of zinc, 10 parts of ammonium polyacrylate.

[0042] Among them, the particle size of silicon dioxide is 300nm, the particle size of zinc oxide is 600nm, and the relative molecular mass of ammonium polyacrylate is 3000

[0043] Prepare the preparation method of above-mentioned bioactive glass-ceramic, comprise the following steps:

[0044] (1) Weigh sodium oxide, zirconium oxide, phosphorus pentoxide, sodium fluoride, strontium oxide, silicon dioxide, zinc oxide and ammonium polyacrylate in parts by weight, mix and add in the orange pot;

[0045] (2) Heating the crucible, holding it at 1550°C for 1.5h, quenching to form a frit, and crushing into glass powder;

[0046] (3) Melt the glass powder in a citrus pot...

technical field

[0001] The invention belongs to the field of bioactive materials, and in particular relates to a preparation method of a bioactive glass-ceramic material used for bone defect repair. Background technique

[0002] Skeletal lesion is a clinical common disease and frequently-occurring disease. Through the development of bone repair and bone substitute materials, it can help patients repair defective or missing bone tissue and better restore the function of human tissue. In bone tissue engineering, an ideal repair material should meet the following conditions: good biocompatibility, biodegradability, plasticity, three-dimensional porous and interconnected pore structure and certain mechanical strength. In the field of bone defect repair research, there is an urgent need for scaffold materials that match the mechanical strength of human bone, have good cell compatibility, and promote the growth of new bone tissue.

[0003] Bioactive materials are materials used ...

Examples

Embodiment 1

[0025] A bioactive glass-ceramic, comprising the following raw materials in parts by weight: 58 parts of sodium oxide, 18 parts of zirconia, 12 parts of phosphorus pentoxide, 8 parts of sodium fluoride, 8 parts of strontium oxide, 22 parts of silicon dioxide, 30 parts of zinc, 6 parts of ammonium polyacrylate.

[0026] Wherein, the particle diameter of silicon dioxide is 250nm, the particle diameter of zinc oxide is 500nm, and the relative molecular mass of ammonium polyacrylate is 1000.

[0027] Prepare the preparation method of above-mentioned bioactive glass-ceramic, comprise the following steps:

[0028] (1) Weigh sodium oxide, zirconium oxide, phosphorus pentoxide, sodium fluoride, strontium oxide, silicon dioxide, zinc oxide and ammonium polyacrylate in parts by weight, mix and add in the orange pot;

[0029] (2) Heating the crucible, keeping it at 1500°C for 2 hours, quenching to form a frit, and crushing into glass powder;

[0030] (3) Melt the glass powder in a citr...

Embodiment 2

[0033] A bioactive glass-ceramic, comprising the following raw materials in parts by weight: 50 parts of sodium oxide, 12 parts of zirconia, 5 parts of phosphorus pentoxide, 6 parts of sodium fluoride, 4 parts of strontium oxide, 16 parts of silicon dioxide, 10 parts of zinc, 3 parts of ammonium polyacrylate.

[0034] Wherein, the particle diameter of silicon dioxide is 350nm, the particle diameter of zinc oxide is 800nm, and the relative molecular mass of ammonium polyacrylate is 5000.

[0035] Prepare the preparation method of above-mentioned bioactive glass-ceramic, comprise the following steps:

[0036] (1) Weigh sodium oxide, zirconium oxide, phosphorus pentoxide, sodium fluoride, strontium oxide, silicon dioxide, zinc oxide and ammonium polyacrylate in parts by weight, mix and add in the orange pot;

[0037] (2) Heating the crucible, holding it at 1600°C for 1 hour, quenching to form a frit, and crushing into glass powder;

[0038] (3) Melt the glass powder in a citrus...

Embodiment 3

[0041] A bioactive glass-ceramic, comprising the following raw materials in parts by weight: 70 parts of sodium oxide, 25 parts of zirconia, 16 parts of phosphorus pentoxide, 12 parts of sodium fluoride, 14 parts of strontium oxide, 28 parts of silicon dioxide, 40 parts of zinc, 10 parts of ammonium polyacrylate.

[0042] Among them, the particle size of silicon dioxide is 300nm, the particle size of zinc oxide is 600nm, and the relative molecular mass of ammonium polyacrylate is 3000

[0043] Prepare the preparation method of above-mentioned bioactive glass-ceramic, comprise the following steps:

[0044] (1) Weigh sodium oxide, zirconium oxide, phosphorus pentoxide, sodium fluoride, strontium oxide, silicon dioxide, zinc oxide and ammonium polyacrylate in parts by weight, mix and add in the orange pot;

[0045] (2) Heating the crucible, holding it at 1550°C for 1.5h, quenching to form a frit, and crushing into glass powder;

[0046] (3) Melt the glass powder in a citrus pot...