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Compound as well as preparation method and application thereof

A compound and catalyst technology, applied in the field of amino acid surfactant preparation, can solve the problem of poor decontamination ability of surfactants

Active Publication Date: 2018-11-06
SUZHOU OULIT BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they belong to the surfactants based on biological substances, they have high safety, good biodegradability and excellent skin feel, and have attracted more and more attention. However, due to the poor decontamination ability of such surfactants, It is seldom used alone as a main surfactant, and often needs to be used in combination with other main surfactants, which does not fundamentally solve the negative problems of daily chemical main surfactants in terms of safety and biodegradability

Method used

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  • Compound as well as preparation method and application thereof
  • Compound as well as preparation method and application thereof
  • Compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] The synthesis of embodiment 1 N-lauroyl-L-alanine

example 1

[0110] At room temperature, in a 2L three-neck flask, dissolve 16.0g (0.1mol) L-alanyl-L-alanine and 4..0g (0.1mol) sodium hydroxide in a mixed solution of 450mL distilled water and 450mL acetone Stir in medium to obtain L-alanyl-L-alanine sodium solution.

[0111] Under the condition of 25 DEG C, in the L-alanyl-L-alanine salt solution, slowly add 21.9g (0.1mol) lauroyl chloride dropwise, then add dropwise 50% sodium hydroxide solution so that the pH of the reaction system= 9. After the dropwise addition, continue stirring at 25° C. for 2 h to obtain pasty N-lauroyl-L-alanyl-L-alanine salt.

[0112] Add hydrochloric acid to the pasty N-lauroyl-L-alanyl-L-alanine salt to acidify to pH = 3~4, gradually precipitate a white solid, then place it in an ice bath for 2 hours and filter to obtain N- Lauroyl-L-alanyl-L-alanine crude.

[0113] Add a mixed solvent of water and acetone, L-alanyl-L-alanine and p-toluenesulfonic acid to the crude N-lauroyl-L-alanyl-L-alanine, wherein, N-l...

example 2

[0116] At room temperature, in a 2L three-neck flask, dissolve 16.0g (0.1mol) L-alanyl-L-alanine and 6.0g (0.15mol) potassium hydroxide in a mixed solution of 450mL distilled water and 450mL acetonitrile and stir Uniformly obtain L-alanyl-L-alanine sodium solution.

[0117] Under the condition of 25 DEG C, in the L-alanyl-L-alanine salt solution, slowly add 17.52g (0.08mol) lauroyl chloride dropwise, then add dropwise 30% sodium hydroxide solution so that the pH of the reaction system= 9. After the dropwise addition, continue stirring at 50° C. for 0.5 h to obtain pasty N-lauroyl-L-alanyl-L-alanine salt.

[0118] Add hydrochloric acid to the pasty N-lauroyl-L-alanyl-L-alanine salt to acidify to pH = 3~4, gradually precipitate a white solid, then place it in an ice bath for 3 hours and filter to obtain N- Lauroyl-L-alanyl-L-alanine crude.

[0119] Add a mixed solvent of water and acetone, L-alanyl-L-alanine and p-toluenesulfonic acid to the crude N-lauroyl-L-alanyl-L-alanine,...

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Abstract

The invention discloses a compound. The compound is N-lauroyl-L-alanyl-L-alanine or salts of N-lauroyl-L-alanyl-L-alanine, wherein the salts include N-lauroyl-L-alanyl-L-sodium alanine and N-lauroyl-L-alanyl-L-potassium alanine. The compound discloses by the invention has effective effects of bacteriostasis, pesticide removal and the like, and can be widely applied to daily use chemical, agriculture and medicine industry. The invention also discloses three methods for preparing the compound. The product obtained by the method has high yield and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of preparation of amino acid surfactants, and in particular relates to a compound and its preparation method and application. Background technique [0002] Surfactants are an essential part of many fields such as daily chemical industry, agriculture, and pharmaceutical industry. There are dozens of surfactants currently used in the market, but the commonly used ones are mainly sodium dodecylbenzenesulfonate (SLS), sodium lauryl polyoxyethylene ether sulfate (AES) and sodium lauryl sulfate ( K12) mainly. Since these three surfactants have been used for decades or even hundreds of years, their negative effects have gradually emerged during the use process, and their impact on human safety and the environment is often reported. [0003] Other surfactants, such as carbohydrate alkyl glycosides (APG), amino acid surfactants, such as lauroyl-L-glutamic acid, lauroyl glycine, lauroyl sarcosine, etc. Although the...

Claims

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Application Information

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IPC IPC(8): C07K5/062C07K1/02B01F17/22B01F17/28C09K23/22C09K23/28
CPCC07K5/06026C09K23/00
Inventor 张健
Owner SUZHOU OULIT BIOPHARM CO LTD
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