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Antibacterial modification method of polymer materials

A polymer material and modification technology, applied in the field of antibacterial materials, can solve the problems of biosafety, easy leakage of nano-silver, and inability to form chemical bonds between polymers and nano-silver, so as to avoid biosafety problems.

Active Publication Date: 2018-11-06
济南鸿湾生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, no matter the antibacterial materials prepared by the physical mixing method or the in situ reduction method, the inevitable defect is that the polymer and the nano-silver cannot form a strong chemical bond, and the two only rely on the intermolecular interaction to construct the material. Nanosilver is easy to leak during the process, causing serious biosafety problems

Method used

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  • Antibacterial modification method of polymer materials
  • Antibacterial modification method of polymer materials
  • Antibacterial modification method of polymer materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1. Synthesis of diazomethane

[0062] (1) Synthesis of compound 1

[0063] Weigh 4.42 g of sulfide anisole and dissolve in 50 mL of dichloromethane, then add 5.00 g of benzoyl chloride dropwise, and stir at room temperature for 24 hours after the dropwise addition. After the reaction, wash with 50 mL of saturated brine three times. The lower organic phase was dried with about 10 g of anhydrous magnesium sulfate, filtered, and rotary evaporated to obtain a crude product. The crude product was dissolved in dichloromethane, and then separated by column chromatography with the ratio of n-hexane:ethyl acetate=4:1 to obtain a pure product (yield 30%).

[0064] (2) Synthesis of compound 2

[0065] Add compound 1 (1g) and 35mL of absolute ethanol into a 100mL round-bottomed flask. After completely dissolving, add 80% hydrazine hydrate (2.19g), then add 2 drops of acetic acid, reflux at 85°C, and the reaction time is 48 hours. After the reaction is complete, perform post-pro...

Embodiment 2

[0076] 1. Synthesis of diazomethane

[0077] With embodiment 1.

[0078] 2. Surface modification of nylon cloth

[0079] Dissolve 0.2g of compound 3 in 5mL of dichloromethane solution, add 2cm×2cm×0.1cm nylon cloth to fully soak the nylon cloth. Then, dichloromethane was removed by rotary evaporation, so that compound 3 was evenly adsorbed on the surface of nylon cloth. Put it into a forced air drying oven and heat it to 120° C. and keep it for 20 minutes. The color of the nylon cloth changed from purple to yellow, indicating that the chemical modification was completed. Finally, wash the nylon cloth with dichloromethane 3 times, 20 mL each time, and dry it in a blast drying oven after washing.

[0080] 3. Preparation of nano-silver solution

[0081] With embodiment 1.

[0082] 4. Preparation of antibacterial nylon cloth

[0083] The silver nanoparticles solution (5 mL) was dissolved in 15 mL of ethylene glycol solution. Then, soak the surface-modified nylon cloth in t...

Embodiment 3

[0085] 1. Synthesis of diazomethane

[0086] With embodiment 1.

[0087] 2. Surface modification of polyurethane

[0088] Dissolve 0.2g of compound 3 in 5mL of cyclohexane solution, add dropwise on the surface of a 2cm×2cm×0.1cm polyurethane film, and blow dry with an ear wash ball while adding, so that compound 3 is evenly adsorbed on the surface of the polyurethane film. Put it into a forced air drying oven and heat it to 120° C. and keep it for 20 minutes. The color of the polyurethane changes from purple to yellow, indicating that the chemical modification is complete. Finally, the polyurethane was washed 3 times with cyclohexane, 20 mL each time, and dried in a blast drying oven after washing.

[0089] 3. Preparation of nano-silver solution

[0090] With embodiment 1.

[0091] 4. Preparation of antibacterial polyurethane film

[0092] The silver nanoparticles solution (5 mL) was dissolved in 15 mL of ethylene glycol solution. Then, soak the surface-modified polyure...

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Abstract

The invention relates to an antibacterial modification method of polymer materials. The antibacterial modification method comprises following steps: preparing diazomethane with a thioether group; using diazomethane to carry out chemical modification on the surface of a polymer material; and carrying out Ag-S coordination reactions between a nano silver particle solution and the chemically modifiedpolymer material. After antibacterial modification, Ag is bonded with the polymer material through chemical bonds, so during the using process, silver leakage is prevented, and the biological safetyis guaranteed.

Description

technical field [0001] The invention relates to an antibacterial modification method of polymer materials, belonging to the technical field of antibacterial materials. Background technique [0002] At present, the biggest problem with implantable / interventional medical polymer materials is that bacteria tend to adhere to the surface and form biofilms during clinical application, which can cause infection, surgery and medical accidents. According to preliminary statistics from the National Institutes of Health, 80% of bacterial diseases are related to medical materials. Bacterial biofilms commonly exist on artificial devices in the body, and have strong drug resistance and immune evasion. Even a drug that is hundreds of times the normal dose cannot be effectively removed, which often endangers the lives of patients. Taking the cardiovascular system as an example, the mortality rate due to infection of artificial devices is close to 100%. Therefore, obtaining medical polymer...

Claims

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Application Information

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IPC IPC(8): D06M11/83D06M13/322D06M13/252C08J7/12C07C319/20C07C323/48D06M101/06D06M101/34C08L75/04
CPCC07C319/20C08J7/12C08J2375/04D06M11/83D06M13/252D06M13/322D06M16/00D06M2101/06D06M2101/34C07C323/48
Inventor 杨鹏飞潘韵霖王永清柳沛丰
Owner 济南鸿湾生物技术有限公司
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