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Polylysine composite hydrogel and preparation method thereof

A technology of composite hydrogel and polylysine, applied in the field of polylysine composite hydrogel and its preparation, to achieve the effect of reducing scar formation, good application prospects, and accelerating wound healing

Inactive Publication Date: 2018-11-13
HUNAN GUOSHENG GRAPHITE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and insufficiencies of the above-mentioned prior art, aiming at skin wounds caused by trauma, burns, scalds, operations, etc. To solve such problems, provide a polylysine composite hydrogel with low toxicity and side effects, which can effectively inhibit scar formation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of polylysine composite hydrogel

[0024] (1) This example provides a polylysine composite hydrogel, which is prepared from polylysine, nitrogen-doped graphene, and scutellarin. The dosage of each component is: polylysine (10KDa ) 3g, nitrogen-doped graphene (3KDa) 0.5g, scutellarin 1.5g.

[0025] (2) Preparation method

[0026] According to the above quality, the raw materials of each component were respectively selected for use, and the breviscapine / polylysine composite hydrogel was prepared. The specific method included the following steps:

[0027] S1. Dissolving polylysine in acetic acid solution to obtain polylysine acetic acid solution; adding nitrogen-doped graphene to polylysine acetic acid solution and mixing to obtain polylysine / nitrogen-doped graphene mixed solution ;

[0028] S2. Adding the scutellarin powder into the polylysine / nitrogen-doped graphene mixed solution, stirring and mixing evenly, and degassing to obtain the scutellar...

Embodiment 2

[0030] Example 2 Preparation of polylysine composite hydrogel

[0031] This example provides a polylysine composite hydrogel that inhibits scar formation, which is prepared from polylysine, nitrogen-doped graphene, and breviscapine, and the dosage of each component is: polylysine ( 20KDa) 5g, nitrogen-doped graphene (8KDa) 0.8g, scutellarin 1.8g.

[0032] For the specific preparation method, refer to Example 1, which will not be repeated here.

Embodiment 3

[0033] The preparation of embodiment 3 polylysine composite hydrogel

[0034] This example provides a polylysine composite hydrogel that inhibits scar formation, which is prepared from polylysine, nitrogen-doped graphene, and breviscapine, and the dosage of each component is: polylysine ( 100KDa) 4g, nitrogen-doped graphene (5KDa) 0.7g, scutellarin 1.6g.

[0035] For the specific preparation method, refer to Example 1, which will not be repeated here.

[0036] The hydrogel provided by the invention can accelerate the healing of wounds through the effective combination of breviscapine, polylysine and nitrogen-doped graphene, has the characteristics of hemostasis, antibacterial and inhibits scar formation from the root, can shorten the Clotting time, accelerated wound healing and reduced scar formation. The preparation method of the hydrogel is simple and convenient, and has strong practicability. The polymer materials used are all non-toxic and biodegradable materials, and th...

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Abstract

The invention belongs to the technical field of biomedical materials, in particular to polylysine composite hydrogel and a preparation method thereof. The polylysine composite hydrogel is prepared from the following raw materials of breviscapine, polylysine and nitrogen doped graphene of which a mass ratio is (1 to 2):(3 to 5):(0.5 to 1) through compounding. The polylysine composite hydrogel disclosed by the invention is capable of accelerating the healing of wounds through effective combination of the breviscapine, the polylysine and the nitrogen doped graphene, has the characteristics that stopping bleeding, inhibiting bacteria and fundamentally inhibiting cicatrization, and is capable of shortening the blood clotting time, accelerating the wound healing and reducing the cicatrization. The preparation method of the polylysine composite hydrogel is simple and convenient and strong in practicability, used high polymer materials are all non-toxic and degradable materials, and the prepared polylysine composite hydrogel has the advantages of good biocompatibility, good biodegradability, good absorption, safety, no toxicity and the like and has a very good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials. More specifically, it relates to a polylysine composite hydrogel and a preparation method thereof. Background technique [0002] Scar is the disorder of fibroblast proliferation in the skin dermis, resulting in excessive production of fibroblasts and excessive deposition of collagen. It is a common complication after skin trauma and surgery, and seriously affects the appearance and psychology of patients. The pathogenesis of scar and its prevention and treatment methods have always been a research hotspot in the medical field, and there is no clear conclusion on its pathogenesis. Scar is the product of skin wound repair and healing process. Except for superficial wounds that can be repaired by simple epithelial formation, any damage that reaches deep into the dermis and subcutaneous tissue will be repaired by scar formation. Theoretically speaking, once the scar is formed, even if ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/009A61L26/0095A61L2300/232A61L2300/404A61L2300/412A61L2300/418A61L2300/604C08L77/04
Inventor 林前锋
Owner HUNAN GUOSHENG GRAPHITE TECH CO LTD