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Anti-inflammatory and bacteriostatic medical dressing

A medical and oily liposome technology, applied in the field of dressing preparation, can solve the problems of wound bacterial infection, poor hemostatic effect, unfavorable wound healing, etc., achieve good biocompatibility and prolong the effective time

Active Publication Date: 2018-11-20
DONGBEI MEDICAL EQUIP (SHANDONG) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem mainly solved by the present invention: the most commonly used dressings in clinical practice are mainly gauze, cotton pads, etc., which belong to inert dressings, which are not conducive to the healing of wounds, easily cause bacterial infection of wounds, and have poor hemostatic effect. As a kind of natural antibacterial Tea tree oil itself is volatile and highly irritating, difficult to preserve, poor in stability, affects the performance of the drug and brings inconvenience to its clinical application, and provides a tea tree oil liposome anti-inflammatory and antibacterial medical dressing The preparation method of the method is to obtain an impregnation solution by preparing tea tree oil liposome and chitosan solution, and then hemp and viscose composite fibers are reinforced by hydroentanglement, immersed in the impregnation solution and ultrasonically loaded, and the anti-aging agent is obtained after hot pressing. Inflammation and antibacterial medical dressings, in which tea tree oil is made into liposomes to solve the problems of strong volatility and poor stability, and the liposomes themselves have a slow-release effect, which can prolong the effective time of antibacterial and anti-inflammatory, and the compounding of chitosan To make it have better biocompatibility, the fiber dressing made by spunlace method has the advantages of softness, hygiene, breathability, moisture absorption and no hairiness. The medical dressing made by compounding combines the advantages of various raw materials and is a comfortable Effective Medical Products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Weigh 150g of soybean lecithin, 20g of cholesterol and 2g of sodium cholate and dissolve them in 500mL of absolute ethanol, shake and dissolve on a shaker for 1 hour, pour them into a 1L flask, and place them on a rotary evaporator to rotate at a speed of 50r / min. Remove absolute ethanol by steaming to form a uniform lipid film on the inner wall of the flask; measure 50mL of tea tree oil and 100mL of pH 6.5 phosphate buffer and pour them into the above-mentioned conjunctiva flask, put them into a vortex oscillator, and shake and wash with 30W power. Remove the lipid film on the wall of the bottle, and then move the flask into a microwave reactor after elution, hydration reaction at 45°C for 40 minutes, and obtain tea tree oil liposomes after filtering with a microporous membrane, and set aside; weigh 300g of hemp The fiber and 200g viscose fiber are evenly spread on the screen, and 30mL paraffin oil is evenly sprayed on the fiber in the form of mist. After the spraying, ...

example 2

[0022]Weigh 200g of soybean lecithin, 25g of cholesterol and 3g of sodium cholate and dissolve them in 550mL of absolute ethanol, shake and dissolve on a shaker for 1.5h, then pour into a 1L flask, place on a rotary evaporator at a speed of 55r / min Remove absolute ethanol by rotary evaporation, and form a uniform lipid film on the inner wall of the flask; measure 80mL of tea tree oil and 150mL of pH 6.5 phosphate buffer and pour them into the above conjunctiva flask, put them into a vortex shaker, and use 35W power Oscillate and elute the lipid film on the bottle wall, and then move the flask into a microwave reactor after elution, hydration reaction at 50°C for 45min, and obtain tea tree oil liposomes after filtration with a microporous membrane, and set aside; weigh 350g Spread hemp fiber and 250g viscose fiber evenly on the screen, spray 35mL paraffin oil evenly on the fiber in the form of mist, after spraying, let the fiber stand for 25 hours and put it into the cotton mixi...

example 3

[0025] Weigh 250g of soybean lecithin, 30g of cholesterol and 4g of sodium cholate and dissolve them in 600mL of absolute ethanol, shake and dissolve on a shaker for 2 hours, then pour into a 1L flask, place on a rotary evaporator and rotate at a speed of 60r / min. Remove absolute ethanol and form a uniform lipid film on the inner wall of the flask; measure 100mL of tea tree oil and 200mL of pH 6.5 phosphate buffer and pour them into the above conjunctiva flask, put them in a vortex shaker, and shake and elute with 40W power After the lipid film on the bottle wall is eluted, the flask is moved into a microwave reactor, hydrated at 55°C for 50 minutes, and filtered with a microporous membrane to obtain tea tree oil liposomes for subsequent use; weigh 400g of hemp fiber Spread 300g of viscose fiber evenly on the sieve, spray 40mL of paraffin oil evenly on the fiber in the form of mist, after spraying, leave the fiber to lubricate for 30 hours, then put it into the cotton mixing bo...

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PUM

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Abstract

The invention relates to an anti-inflammatory and bacteriostatic medical dressing and belongs to the field of dressing preparation. Impregnating solution is prepared in the method through combining atea oil plastid with chitosan solution. And after reinforcing hemp and viscose composite fibers by spunlaced, the hemp and the viscose composite fibers are immersed into the impregnating solution under ultrasonic loading. After hot pressing, the anti-inflammatory and bacteriostatic medical dressing is obtained, which solves the problem of strong volatility and poor stability of tea tree oil aftermade into liposomes, and the liposomes themselves have sustained-release effect which can prolong the effective time of anti-bacterial and anti-inflammatory. The combination of chitosan makes the liposomes has better biocompatibility. A fiber dressing made by a spunlaced method has the advantages of softness, hygiene, breathability, moisture absorption and featherless. The medical dressing made bythe combination synthesizes the advantages of various raw materials and is a comfortable and effective medical product.

Description

technical field [0001] The invention relates to an anti-inflammatory and antibacterial medical dressing, which belongs to the field of dressing preparation. Background technique [0002] The skin is the largest organ of the human body. It has important functions such as resisting the invasion of external microorganisms, excreting and preventing water evaporation, regulating body temperature, and maintaining the stability of the body's internal environment. Scholars from all over the world are committed to actively promoting wound healing through various methods. As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. [0003] At present, the most commonly used dressings in clinical practice are mainly gauze, cotton pads, etc., which are mostly processed from cotton, burlap and linen. They are inert dressings and have no obv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/28A61L15/40A61L15/44A61L15/46
CPCA61F13/00063A61F13/02A61F13/0276A61L15/20A61L15/28A61L15/40A61L15/42A61L15/44A61L15/46A61L2300/30A61L2300/404A61L2300/41A61L2300/602A61L2300/626C08L5/08
Inventor 不公告发明人
Owner DONGBEI MEDICAL EQUIP (SHANDONG) CO LTD
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