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Liquid crystal polyurethane urea material with cholesteric side chains and preparation method of liquid crystal polyurethane urea

A technology of polyurethane urea and cholesterol, which is applied in the direction of liquid crystal materials, chemical instruments and methods, etc., can solve the problems that the oxidation rate of PU film cannot be guaranteed, the surface mechanism of materials will be damaged, and the mechanical properties of polymers will be damaged, so as to improve blood compatibility Good blood compatibility and biocompatibility, the effect of improving blood compatibility

Active Publication Date: 2018-11-30
广州迈腾化工科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of surface grafting cannot guarantee the oxidation rate of the PU film firstly, and secondly, the grafting rate is also very low, generally at 10 -8 about
And the method of grafting will destroy the surface mechanism of the material
The grafts are easy to fall off. After falling off, the mechanical properties of the polymer itself will be destroyed, and the biocompatibility will be greatly reduced.

Method used

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  • Liquid crystal polyurethane urea material with cholesteric side chains and preparation method of liquid crystal polyurethane urea
  • Liquid crystal polyurethane urea material with cholesteric side chains and preparation method of liquid crystal polyurethane urea
  • Liquid crystal polyurethane urea material with cholesteric side chains and preparation method of liquid crystal polyurethane urea

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Under the protection of dry nitrogen, 10.94g (15mmol) single-ended dihydroxy liquid crystal monomer (DAP) and 5.0g (5mmol) polyethylene glycol (PEG, M n =1000) were mixed, N,N-dimethylformamide (DMF) was added to dissolve (0.5g / mL), the temperature of the reaction system was raised to 80°C, and a DMF solution (1.0g / mL) of HBH (20.2mmol) was added dropwise, After the dropwise addition, keep the temperature and continue the reaction for 4.0 h, lower to room temperature, then add DMF to prepare a solution with a concentration of 8 g / 100 ml, settle with 8 times the volume of glacial ether, and dry the obtained solid under vacuum at 35°C.

[0069] Dissolve the solid in tetrahydrofuran, an organic solvent, to a concentration of 6.0g / 100mL, volatilize it in a polytetrafluoroethylene mold at 25°C under normal pressure for 80 hours, remove the film from the mold, and dry it in vacuum at room temperature for 1 day to obtain side Chain type liquid crystal polyurethane urea film ma...

Embodiment 2

[0071] Under the protection of dry nitrogen, 21.87g (30mmol) terminal dihydroxy liquid crystal monomer (DAP) and 5.0g (5mmol) polyethylene glycol (PEG, M n =1000) were mixed, N,N-dimethylformamide (DMF) was added to dissolve (0.4g / mL), the temperature of the reaction system was raised to 85°C, and a DMF solution (0.8g / mL) of HBH (35.7mmol) was added dropwise, After the dropwise addition, keep the temperature and continue the reaction for 3.5 hours, lower to room temperature, then add DMF to prepare a solution with a concentration of 6g / 100ml, settle with 8 times the volume of glacial ether, and dry the obtained solid under vacuum at 45°C.

[0072] Dissolve the solid in the organic solvent tetrahydrofuran to a concentration of 5.5g / 100mL, volatilize it in a polytetrafluoroethylene mold at 15°C under normal pressure for 75 hours, remove the film from the mold, and dry it in vacuum at room temperature for 1 day to obtain the side Chain type liquid crystal polyurethane urea film m...

Embodiment 3

[0074] Under the protection of dry nitrogen, 7.29g (10mmol) terminal dihydroxy liquid crystal monomer (DAP) and 15.0g (5mmol) polyethylene glycol (PEG, M n =3000) were mixed, N,N-dimethylformamide (DMF) was added to dissolve (0.6g / mL), the temperature of the reaction system was raised to 75°C, and a DMF solution (0.6g / mL) of HBH (26.25mmol) was added dropwise, After the dropwise addition, keep the temperature and continue the reaction for 4.5 h, lower to room temperature, then add DMF to prepare a solution with a concentration of 9 g / 100 ml, settle with 8 times the volume of glacial ether, and dry the obtained solid under vacuum at 40°C.

[0075]Dissolve the solid in the organic solvent tetrahydrofuran to a concentration of 5.5g / 100mL, volatilize it in a polytetrafluoroethylene mold at 25°C under normal pressure for 70 hours, remove the film from the mold, and dry it in vacuum at room temperature for 1 day to obtain the side Chain type liquid crystal polyurethane film material...

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Abstract

The invention provides liquid crystal polyurethane urea with cholesteric side chains and a preparation method of the liquid crystal polyurethane urea. Cholesteric liquid crystal units are connected toa main chain through long flexible segments in a covalently mode, single-end dihydroxy cholesteric liquid crystal monomer (DAP) is mixed with double-end hydroxyl polyethylene glycol (PEG), chain extension is performed by using diisocyanate containing a urea-based structure, and the liquid crystal polyurethane urea with the cholesteric side chains is obtained through purification. The liquid crystal polyurethane has a number average molecular weight of 1.0*10<5>-5.0*10<5> and a dispersion coefficient of 1.20-1.51, the mass content of DAP in the liquid crystal polyurethane is 25-52%, and the mass content of PEG in the liquid crystal polyurethane is 12-52%. By combining a cholesteric liquid crystal into polyurethane through a condensation polymerization mode, not only can migration of the small molecule liquid crystal be avoided, but also the blood compatibility and biocompatibility of a polyurethane film can be improved; therefore, reference is provided for application of the modified polyurethane material in biomedical engineering, and good biodegradability can be obtained.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a cholesterol side chain liquid crystal polyurethane urea material and a preparation method thereof. Background technique [0002] Polyurethane material (PU) has excellent mechanical properties and good biocompatibility. At present, many medical devices are made of polyurethane, such as artificial valves, artificial hearts, artificial heart assist devices, and artificial blood vessels. Intervention catheter, artificial joint, artificial cartilage and artificial ureter, etc. [0003] Biomaterials are used as the base materials of medical devices for temporary intervention or permanent implantation in the human body. In addition to having appropriate mechanical properties, they must also have excellent biocompatibility (biocompatibility). Biocompatibility includes two parts: blood compatibility and tissue compatibility. The former indicates the degree of mut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/78C08G18/66C08G18/48C08G18/32C08J5/18C08L75/08C09K19/38
CPCC08G18/3868C08G18/4833C08G18/6666C08G18/7825C08G2250/00C08J5/18C08J2375/08C09K19/3885
Inventor 侯昭升肖铭慧张鋆李成林赵娟刘昭君
Owner 广州迈腾化工科技有限公司
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