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Infrared light controlled release drug loaded platform and preparation method and application thereof

An infrared light and drug-loading technology, which is applied in the directions of medical formula, drug combination, drug delivery, etc., can solve the problems of ineffective anti-cancer, non-anti-cancer ability of nickel-titanium alloy stents, reocclusion, etc.

Active Publication Date: 2018-12-04
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nickel-titanium alloy stent itself does not have anti-cancer ability, and it is prone to reocclusion after implantation. In order to prevent this phenomenon, drug-loaded stents have gradually become a hot spot in current research.
The control of drug release is one of the main problems in the preparation of drug-loaded stents. Too little drug release will not achieve anti-cancer effects, and too much drug release will cause damage to normal tissues.
However, there is no report on the controlled release of drugs loaded in layered double hydroxides

Method used

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  • Infrared light controlled release drug loaded platform and preparation method and application thereof
  • Infrared light controlled release drug loaded platform and preparation method and application thereof
  • Infrared light controlled release drug loaded platform and preparation method and application thereof

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preparation example Construction

[0067] The preparation method of the above-mentioned gold nanorods is not particularly limited, as long as the gold nanorods of the desired size can be obtained. In one embodiment of the present invention, the aforementioned gold nanorods can be prepared by using chloroauric acid as a raw material and reducing it with sodium borohydride. The preparation process of gold nanorods includes the preparation of seed crystal solution and the preparation of growth liquid (also called growth liquid).

[0068] In one example, when the seed solution is prepared, 0.04-0.24ml (for example, 0.12ml) of 0.01-0.4M HAuCl is added to 5ml of 0.05-0.4M cetyltrimethylammonium bromide (CTAB) solution 4 solution, stirred and added 1 to 10ml of distilled water. Then add 0.1-1ml of frozen 0.002-0.3mol / l NaBH dropwise 4 solution, namely the seed solution. The prepared solution can be used after standing in an environment of 27-30°C for 2-5 hours.

[0069] In one example, when preparing the growth so...

Embodiment 1

[0074] A nickel-titanium alloy disc with a diameter of 12 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic cleaning in sequence, each time for 15 min. with 6mM NiCl 2 , 2mM TiCl 4 , 6.5g / L urea mixed solution was used as hydrothermal medium for hydrothermal treatment, the hydrothermal temperature was 120°C, and the time was 24h. The filling degree of the hydrothermal kettle is 35%.

[0075] figure 1 (LDH) is the low-magnification and high-magnification scanning electron microscope pictures of the surface morphology of the sample obtained through the modification treatment of this embodiment. It can be seen from the figure that the prepared drug-loaded film presents a sheet-like structure, the length and width of the sheet are about 2 μm, and the thickness is 20-40 nm. figure 2 (LDH) provides the XRD spectrum of the sample prepared after the treatment of this embodiment, from which it can be seen that the characteristic peaks correspondin...

Embodiment 2

[0077] A nickel-titanium alloy disc with a diameter of 12 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic cleaning in sequence, each time for 15 min. with 6mM NiCl 2 , 2mM TiCl 4 , 6.5g / L urea, a mixed solution of 3mM sodium butyrate was used as a hydrothermal medium for hydrothermal treatment. Other processing parameters are as described in Example 1.

[0078] figure 1 (LDH / B) is the low-magnification and high-magnification scanning electron microscope pictures of the surface morphology of the sample obtained through the modification treatment of this embodiment. It can be seen from the figure that the morphology of the sample treated in this embodiment is completely consistent with the morphology of the sample processed in Example 1, both of which are composed of nanosheets. figure 2 (LDH / B) provides the XRD spectrogram of the sample prepared after the treatment of the present embodiment, from the figure it can be seen that the charac...

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Abstract

The invention provides an infrared light controlled release drug loaded platform and a preparation method and an application thereof. The infrared light controlled release drug loaded platform includes a medical titanium matrix material; a layered double hydroxide film growing in situ on the surface of the medical titanium matrix material, wherein the interior of a lattice of layered double hydroxide is loaded with a drug, preferably an anticancer drug, more preferably an anionic anticancer drug; and a gold nanorod modified on the surface of the layered double hydroxide. The infrared light controlled release drug loaded platform is strong in drug release controllability, organically combines thermal therapy and chemotherapy, and exhibits a better anticancer effect under conditions of infrared light irradiation.

Description

technical field [0001] The present invention relates to an infrared light-controlled release drug-loading platform and its preparation and application. Specifically, it relates to a biomedical titanium-based material as a substrate, on which a layered double hydroxide drug-loading film is grown in situ on the surface. The drug-loading platform obtained by further modifying the gold nanorod of the photothermal element can be regulated by infrared light, which belongs to the technical field of surface modification of metal materials. Background technique [0002] Medical titanium-based materials such as nickel-titanium alloy have good mechanical properties, biocompatibility and unique shape memory effect, and are widely used in the manufacture of medical stents. Good palliative care outcomes (Radiology 1993,187:661-665.). However, the nickel-titanium alloy stent itself does not have anti-cancer ability, and reocclusion is prone to occur after the stent is implanted. In order ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/513A61K31/19A61K31/704A61L31/02A61L31/08A61L31/14A61L31/16A61P35/00B22F9/24B22F1/00C23C18/12B82Y30/00B82Y40/00
CPCA61K41/0042A61K41/0052A61L31/022A61L31/088A61L31/14A61L31/16A61K31/19A61K31/513A61K31/704C23C18/1204C23C18/1241B82Y30/00B82Y40/00B22F9/24A61L2300/416A61L2400/12A61L2420/02A61L2400/16A61L2420/08B22F1/07B22F1/054A61K2300/00
Inventor 刘宣勇王东辉
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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