Insecticidal and antiviral foliar fertilizer and preparation method thereof

A foliar fertilizer and anti-virus technology, applied in nitrogen fertilizer, phosphate fertilizer, organic fertilizer, etc., can solve the problems of poor sterilization, pest control and anti-virus effects, and achieve high product yield, less by-products, and mild reaction conditions.

Inactive Publication Date: 2018-12-21
赵旭萌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the special seaweed foliar fertilizer for tea trees is not suitable for crops, only for tea trees, and the effect of sterilization, pest control and anti-virus is not good.

Method used

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  • Insecticidal and antiviral foliar fertilizer and preparation method thereof
  • Insecticidal and antiviral foliar fertilizer and preparation method thereof
  • Insecticidal and antiviral foliar fertilizer and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A method for preparing insecticidal and antiviral foliage fertilizer, comprising preparation of rimantadine hydrochloride, preparation of saponin extract, and preparation of foliage fertilizer, the specific steps comprising:

[0025] 1) preparation of rimantadine hydrochloride:

[0026] a. Preparation of adamantanecarboxylic acid chloride: Add 1.8g of adamantanecarboxylic acid and 3.6mL of thionyl chloride into a three-necked flask, heat to 80°C, reflux for 2 hours, recover thionyl chloride by vacuum distillation, and then add 5mL of benzene to carry out Extraction, the obtained extract is directly used in the next step reaction;

[0027] b. Preparation of adamantanemethyl ketone: add 0.10g of trimethylaluminum and 0.01g of cerium formate to a three-necked flask, then add a benzene solution of adamantanecarbonyl chloride dropwise at 0.25mL / min to make adamantanecarbonyl chloride and trimethyl Aluminum base reacts to generate adamantyl methyl ketone. After the reaction ...

Embodiment 2

[0034] A method for preparing insecticidal and antiviral foliage fertilizer, comprising preparation of rimantadine hydrochloride, preparation of saponin extract, and preparation of foliage fertilizer, the specific steps comprising:

[0035] 1) preparation of rimantadine hydrochloride:

[0036] a. Preparation of adamantanecarboxylic acid chloride: Add adamantanecarboxylic acid and excess thionyl chloride into a three-necked flask, heat to 80°C, reflux for 2 hours, recover thionyl chloride by vacuum distillation, then add benzene for extraction, and the obtained extract is directly for the next reaction;

[0037] b. Preparation of adamantanemethyl ketone: Add trimethylaluminum and cerium formate to a three-necked flask, and then dropwise add a benzene solution of adamantanecarbonyl chloride at 0.1mL / min to react adamantanecarbonyl chloride with trimethylaluminum to form For adamantane methyl ketone, after the reaction is completed, the reaction solution is poured into ice water...

Embodiment 3

[0044] A method for preparing insecticidal and antiviral foliage fertilizer, comprising preparation of rimantadine hydrochloride, preparation of saponin extract, and preparation of foliage fertilizer, the specific steps comprising:

[0045] 1) preparation of rimantadine hydrochloride:

[0046] a. Preparation of adamantanecarboxylic acid chloride: Add adamantanecarboxylic acid and excess thionyl chloride into a three-necked flask, heat to 80°C, reflux for 2 hours, recover thionyl chloride by vacuum distillation, then add benzene for extraction, and the obtained extract is directly for the next reaction;

[0047] b. Preparation of adamantanemethyl ketone: Add trimethylaluminum and cerium formate to a three-necked flask, and then dropwise add a benzene solution of adamantanecarbonyl chloride at 0.5mL / min to react adamantanecarbonyl chloride with trimethylaluminum to form For adamantane methyl ketone, after the reaction is completed, pour the reaction solution into ice water to o...

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Abstract

The invention discloses insecticidal and antiviral foliar fertilizer and a preparation method thereof. The preparation method comprises preparation of rimantadine hydrochloride, preparation of a saponin extract and preparation of foliar fertilizer, wherein the rimantadine hydrochloride is prepared by the following steps: carrying out heating reflux reaction on adamantanecarboxylic acid and thionylchloride, extracting benzene, slowly adding a benzene extract liquor into a three necked bottle containing trimethylaluminum and cerium formate for reaction, and then treating with ice water to obtain adamantane methyl ketone; adding hydroxylamine hydrochloride, alkali and alcohol for oximation into ketoxime, catalyzing by platinum-carbon for hydrogenation reduction, and then acidizing to form salt by hydrogen chloride gas, so as to obtain rimantadine hydrochloride. The preparation method has the beneficial effects that by preparing rimantadine hydrochloride with trimethylaluminum and ceriumformate, a previous route for synthesizing adamantane methyl ketone is changed, and mild reaction conditions, fewer by-products and high product yield are achieved; the foliar fertilizer prepared withrimantadine hydrochloride not only has insecticidal, antibacterial and antiviral effects, but also is capable of quickly supplementing foliar nutrition.

Description

technical field [0001] The invention relates to the technical field of foliar fertilizers, in particular to an insecticidal and antiviral foliar fertilizer and a preparation method thereof. Background technique [0002] Riantadine hydrochloride is an amino derivative of saturated tricyclodecane, the chemical name is α-methyltricyclo[3,3,1,1]decane-1-methylamine hydrochloride, Bristol Myers Squibb Company, USA Research and development, first launched in France in 1987. Such compounds have antiviral effects. The mechanism of action of rimantadine is to change the surface charge of the host cell, inhibit the process of the virus penetrating into sensitive cells and releasing nucleic acid, and inhibit the proliferation of the virus. In recent years, people have further researched on the synthetic method of rimantadine. [0003] The existing synthetic method of rimantadine hydrochloride uses adamantane as a raw material to first prepare 1-bromoadamantane, then make adamantanec...

Claims

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Application Information

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IPC IPC(8): C05G3/00C05G3/02C05G3/60
CPCC05B7/00C05G3/00C05G3/60C05C9/00C05F11/00
Inventor 赵旭萌
Owner 赵旭萌
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