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A heat-assisted carbon fiber ionization device and a method for realizing ionization using the device

An ionization and carbon fiber technology, applied in the field of mass spectrometry, can solve the problems of poor repeatability and accuracy of quantitative analysis, low ionization efficiency, and inability to ionize, and achieve good ionization effect, simple structure, and low matrix effect. Effect

Pending Publication Date: 2018-12-21
SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the carbon fiber ion source used in conventional CFI-MS is a "soft" ionization source. For some types of compounds, such as sugars and glycosides, the ionization efficiency of conventional CFI-MS is not high or even cannot be ionized; and, the current conventional When CFI-MS performs quantitative analysis of complex matrix samples, the matrix effect is high, which will lead to poor repeatability and accuracy of quantitative analysis

Method used

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  • A heat-assisted carbon fiber ionization device and a method for realizing ionization using the device
  • A heat-assisted carbon fiber ionization device and a method for realizing ionization using the device
  • A heat-assisted carbon fiber ionization device and a method for realizing ionization using the device

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Embodiment 1

[0071] Carbohydrate compounds: glucose, maltose, raffinose and stachyose are carried out to mass spectrometry using the heat-assisted carbon fiber ionization device and mass spectrometer (mass analyzer is a triple quadrupole) of the present invention:

[0072] Dissolve solid glucose, maltose, raffinose and stachyose in ethanol solution respectively to prepare sample solutions with a concentration of 0.1 mg / mL for use; heat the heating device 3 (high-temperature ceramic plate) to 250 °C; The metal hollow tube 6 introduces the auxiliary solvent ethanol (flow rate 2 μL / min), connects the high voltage power supply 4, and applies a high voltage of +2500V to the carbon fiber bundle 5; respectively takes 5 μL of 0.1 mg / mL sample solution, and applies it to the heating device 3 (high-temperature ceramic sheet), the solution is instantly gasified, and the gasified sample is collected and ionized by the sampling and ionization end of the carbon fiber bundle 5, and the ionized sample ente...

Embodiment 2

[0075] Adopt heat-assisted carbon fiber ionization device of the present invention and mass spectrometer (mass analyzer is a triple quadrupole) to carry out mass spectrometry analysis to glycoside compounds: naringin, icariin:

[0076] Dissolve naringin and icariin in ethanol solution respectively to make sample solutions with a concentration of 0.1mg / mL for use; heat the heating device 3 (high-temperature ceramic plate) to 250°C; 6. Introduce the auxiliary solvent ethanol (flow rate 2 μL / min), switch on the high-voltage power supply 4, and apply a high voltage of +2500V to the carbon fiber bundle 5; respectively take 5 μL of 0.1 mg / mL sample solution, and place samples on the heating device 3 (high-temperature ceramic sheet ), the solution is instantly gasified, and the gasified sample is collected and ionized by the sampling and ionization end of the carbon fiber bundle 5, and the ionized sample enters the mass spectrometer through the mass spectrometer sampling channel 1 for...

Embodiment 3

[0079] Adopt heat-assisted carbon fiber ionization device of the present invention and mass spectrometer (mass analyzer is a triple quadrupole) to carry out mass spectrometry to the solid sample without any pretreatment: fresh white radish and dry Chinese wolfberry:

[0080] Cut fresh white radish and dried wolfberry into 0.5mm thick slices with a length and width of 2mm×2mm as a spare sample; heat the heating device 3 (high-temperature ceramic sheet) to 250°C; introduce auxiliary solvent through the metal hollow tube 6 Ethanol (flow rate 2μL / min), connect the high-voltage power supply 4, and apply a high voltage of +2500V to the carbon fiber bundle 5; directly place the sliced ​​solid samples on the heating device 3 (high-temperature ceramic sheet), and the components in the sample are instantly Desorbed out, the desorbed gasification components are collected and ionized by the sampling and ionization end of the carbon fiber bundle 5, and then enter the mass spectrometer throu...

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Abstract

The invention discloses a thermally assisted carbon fiber ionization device and a method for realizing ionization by using the device, The heat-assisted carbon fiber ionization device comprises a carbon fiber ion source and a mass spectrometry sample injection channel, a heating device as a sample carrier is arranged near the sampling and ionization end of the carbon fiber ion source, and the heating device is located at the mass spectrometry sample injection channel. The method for realizing ionization using the heat-assisted carbon fiber ionization device of the present invention comprises the following operations: loading a sample on a heating device, and then the heating device thermally desorbs the sample loaded on the heating device, and then the thermally desorbed sample is ionizedby a carbon fiber ion source. The ionization device of the invention has the advantages of simple structure, simple operation, low cost, environmental protection, cleanliness, easy realization, high sensitivity, high ionization efficiency, low matrix effect, strong universality, wide application range, high throughput and the like, and has the popularization and application value.

Description

technical field [0001] The invention relates to a heat-assisted carbon fiber ionization device and a method for realizing ionization by using the device, belonging to the technical field of mass spectrometry. Background technique [0002] Mass spectrometry (MS) is a powerful tool for the analysis of complex mixtures, providing information about the molecular weight and chemical structure of the analyte. In recent years, with the continuous innovation and improvement of ionization technology and mass analyzers, mass spectrometry has become one of the fastest-growing analytical technologies. At present, mass spectrometry technology is widely used in chemistry and chemical engineering, biology and life science, medicine, pharmacy, Applications in environmental protection and other fields are becoming more and more extensive. [0003] Open ionization mass spectrometry (AI-MS) is a new type of mass spectrometry technology that can directly analyze samples or sample surface subst...

Claims

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Application Information

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IPC IPC(8): H01J49/04H01J49/00
CPCH01J49/0031H01J49/049
Inventor 郭寅龙张强徐小雁王政永张立张菁
Owner SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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