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A method for preparing a liquid bandage

A band-aid and liquid technology, applied in medical science, bandages, etc., can solve the problem of low water vapor transmission rate, achieve the effect of promoting wound healing, good water resistance, and small skin irritation

Active Publication Date: 2019-01-01
绍兴百立盛新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The liquid band-aid uses polyvinyl alcohol resin as a film-forming substance, which has a fast film-forming speed and can be isolated and waterproof, but has the disadvantage of low water vapor transmission rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Weigh 10g of a copolymer composed of styrene-maleic anhydride (SMA-EF-80 from Cray Valley, USA) at 20°C and disperse it in a volume percentage of 60% methylcyclohexane and 40% isopropanol. In the mixed solvent of the composition, a polymer solution with a mass percentage of 8% is prepared;

[0039] (2) Weigh 2g of rosin resin (Shanghai Songxinlin Products Co., Ltd., Grade X gum rosin) and disperse it in a mixed solvent composed of 60% methylcyclohexane and 40% isopropanol by volume to make a mass percentage 3% thickener solution;

[0040] (3) Add the thickener solution prepared in step (2) to the polymer solution prepared in step (1) at a volume ratio of 1:1, and then add 0.1 ppm of graphene / silver composite (Nanjing Xianfeng Nano Material Technology Co., Ltd., XF071), uniformly mixed into liquid band-aids, that is, the concentration of graphene / silver composite in the liquid band-aids is 0.1 mg / L.

Embodiment 2

[0042] (1) Under the protection of nitrogen, add 20 parts of styrene-ethylene-butadiene copolymer (Baling Petrochemical, SEBS YH-503) to 80 parts of 1,2-dichloroethane in a reactor at 10°C Add 1 part of chlorosulfonic acid, stir and react for 18 hours, add 200 parts of ethanol for precipitation washing, and dry to obtain a copolymer composed of styrene-ethylene-butadiene and 4-vinylbenzenesulfonic acid Things.

[0043] (2) Weigh 10g of a copolymer composed of styrene-ethylene-butadiene and 4-vinylbenzenesulfonic acid at 20°C and disperse it in a mixture composed of 70% cyclohexane and 30% isopropanol by volume. In the solvent, make a polymer solution with a mass percentage of 8%;

[0044] (3) Weigh 2g of polyethylene glycol (Liaoning Aoke Chemical Co., Ltd., PEG600) and disperse it in a mixed solvent consisting of 70% cyclohexane and 30% isopropanol to make a 3% mass Thickener solution;

[0045] (4) Add the thickener solution prepared in step (3) to the polymer solution prepared i...

Embodiment 3

[0047] (1) Under the protection of nitrogen, add 16 parts of liquid polybutadiene (Polyvest110, Evonik, Germany) to 85 parts of 1,2-dichloroethane in a reactor at 60°C, and stir until dissolved. Then add 4 parts of fumaric acid and 0.1 part of azobisisobutyronitrile, stir and react for 24 hours, add 300 parts of ethanol for precipitation washing, and dry to obtain a block polymer composed of butadiene and fumaric acid;

[0048] (2) Weigh 10g of the block polymer composed of butadiene and fumaric acid at 20°C and disperse it in a mixed solvent composed of 70% hexane and 30% isopropanol by volume to produce a mass percentage of 8 % Polymer solution;

[0049] (3) Weigh 2g of tributyl citrate (Shandong Kexing Chemical Co., Ltd.) and disperse it in a mixed solvent composed of 70% n-hexane and 30% isopropanol to make a thickening of 1% by mass Agent solution

[0050] (4) Add the thickener solution prepared in step (3) to the polymer solution prepared in step (2) at a volume ratio of 1:1,...

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Abstract

The invention discloses a method for preparing a liquid bandage. The method includes dispersing a block polymer consisting of a non-polar chain segments and polar chain segments into a solvent mixtureconsisting of a non-polar solvent and a polar solvent to prepare a polymer solution; dispersing a thickening agent into a solvent mixture consisting of a non-polar solvent and a polar solvent to prepare a thickening agent solution; adding the thickening agent solution into the polymer solution; then adding a bacteriostatic agent; and fully mixing the mixture to obtain the liquid bandage. The method is simple, and the prepared liquid bandage is simple and convenient to use, not limited to wound sizes or positions, and the like. Compared with other liquid bandages in China, the prepared liquidbandage has advantages of rapid film forming, good film waterproofness, high water vapor permeability of the film, good watertightness, and capability of providing a wet and sterile environment for wounds, promoting better wound healing and shortening healing time.

Description

Technical field [0001] The invention relates to the field of antibacterial isolation medical materials, in particular to a method for preparing liquid band-aids. Background technique [0002] Traditional band-aids are mostly composed of a long flat cloth tape with a small piece of drug-impregnated gauze or absorbent pad in the middle. It has the functions of stopping bleeding, protecting wounds, absorbing exudates, and keeping the wound dry. Its disadvantages are also Obviously, such as unavoidable wound scabs and poor waterproof and vapor permeability, they cannot meet the special needs of patients. As a high-end functional modern medical dressing, liquid band-aids are mainly processed by raw materials such as biocompatible polymers, volatile solvents, and antibacterial agents. Inheriting the advantages of traditional band-aids for hemostasis and wound care, liquid band-aids also have the advantages of biodegradability and autolysis, no scabs on the wound surface, protection of...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0061A61L26/0066A61L2300/104A61L2300/404C08L53/00
Inventor 娄琪超王鹏飞徐意
Owner 绍兴百立盛新材料科技有限公司
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