Method for reducing decomposition of sodium azide solution

Abstract

The invention discloses a method for reducing the decomposition of a sodium azide solution. The method comprises the steps of introducing isopropyl nitrite into the sodium azide solution, and carryingout a reaction for 1-4h at 0-30 DEG C, wherein the molar ratio of the isopropyl nitrite to sodium azide is equal to 1 to 1. According to the method, the decomposition of the sodium azide solution iseffectively reduced by introducing the isopropyl nitrite; the method has an important theoretical significance and a practical guidance for research on a synthesis method of sodium azide and the effective prevention of the decomposition of the sodium azide in a preparation process. Comparative experimental study proves that the isopropyl nitrite has a better effect in reduction of the decomposition rate of the sodium azide compared with ethyl nitrite.

Description

technical field [0001] The invention relates to a method for reducing the decomposition of sodium azide solution. It belongs to the technical field of chemical synthesis. Background technique [0002] Sodium azide, called sodium azide in English, is a colorless, odorless hexagonal crystal that decomposes into metallic sodium and ammonia gas when heated to 410°C. When it decomposes in air, the reaction is exothermic, and the reaction liquid can be further decomposed. As an important fine chemical product, sodium azide is widely used in medicine, pesticide, automobile, military and other fields. In my country, sodium azide is mainly used in the synthesis of cefazolin, cefoperazone, losartan, valsartan, etc., and is an important intermediate of cephalosporin antibiotics and sartan antihypertensive drugs. With the rapid development of the automobile manufacturing industry in my country, the amount of sodium azide used as an inflator for automobile airbags is increasing year b...

AI Technical Summary

Problems solved by technology

Among them, the hydrazine hydrate method is the most widely used to prepare sodium azide, and the synthesis process of reacting ethyl nitrite gas in an ethanol solution containing hydrazine hydrate and sodium hydroxide is often used to produce sodium azide. Solvent, high risk, high environmental protection pressure; long reaction cycle, difficult gas-liquid reaction control, low utilization rate of ethyl nitrite; partial decomposition of sodium azide during the reaction process; a small amount of highly toxic azide in the reaction mother liquor Sodium nitride, large amount of wastewater treatment and other key technical problems

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