Method for preparing honeycomb mesoporous silica microspheres

A mesoporous silica and honeycomb technology, applied in the field of materials science, can solve the problems of poor morphology of honeycomb mesoporous silica, and achieve the effects of easy functional modification, simple operation process and low cost.

Inactive Publication Date: 2019-01-04
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned technical problems in the prior art, the invention provides a kind of preparation method of honeycomb mesoporous silica microsphere, the preparation method of described this kind of honeycomb mesoporous silica microsphere should solve existing The pore wall of the honeycomb mesoporous silica in the technology is too thin and very fragile, and the resulting honeycomb mesoporous silica has poor morphology

Method used

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  • Method for preparing honeycomb mesoporous silica microspheres
  • Method for preparing honeycomb mesoporous silica microspheres
  • Method for preparing honeycomb mesoporous silica microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Honeycomb Mesoporous Silica

[0033] 1) Dissolve 1.16g of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer in 100mL deionized water, stir and disperse evenly to obtain uniform polyethylene oxide-polypropylene oxide -Polyethylene oxide triblock copolymer solution:

[0034] 2) Add 3mL of 1mol / L hydrochloric acid solution and 0.5g potassium chloride to the polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer solution obtained in step (1), and stir evenly Obtain a clear solution:

[0035] 3) Add 3.46 g of tetraethyl orthosilicate to the acidic surfactant solution obtained in step (2) at a stirring speed of 200 r / min, and stir at room temperature for 4 hours to obtain a clear and transparent solution;

[0036] 4) Add the clear and transparent solution obtained in step (3) into pH=8.0 polyethylene glycol phosphate buffer solution by spraying, magnetically stir for 300 min, and centrifuge at 7000 rp...

Embodiment 2

[0041] 1) Dissolve 1.16g of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer in 100mL deionized water, stir and disperse evenly to obtain uniform polyethylene oxide-polypropylene oxide -Polyethylene oxide triblock copolymer solution:

[0042]2) Add 4mL of 1mol / L hydrochloric acid solution and 0.5g potassium chloride to the polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer solution obtained in step (1), and stir evenly Obtain a clear solution:

[0043] 3) Under the condition of a stirring speed of 200r / min, directly add 3.46g of tetraethyl orthosilicate into the transparent solution in step (2), and stir at room temperature for 4 hours to obtain a clear and transparent solution;

[0044] 4) Add the clear and transparent solution obtained in step (3) into the pH=7.0 polyethylene glycol phosphate buffer solution by spraying, stir magnetically for 20 minutes, and centrifuge at 7000 rpm to obtain a white precipitate: the polye...

Embodiment 3

[0048] 1) Dissolve 1.16g of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer in 100mL deionized water, stir and disperse evenly to obtain uniform polyethylene oxide-polypropylene oxide -Polyethylene oxide triblock copolymer solution:

[0049] 2) Add 3mL of 1mol / L hydrochloric acid solution and 0.5g potassium chloride to the polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer solution obtained in step (1), and stir evenly Obtain a clear solution:

[0050] 3) Under the condition of a stirring speed of 200r / min, directly add 3.46g of tetraethyl orthosilicate into the transparent solution in step (2), and stir at room temperature for 4 hours to obtain a clear and transparent solution:

[0051] 4) Add the clear and transparent solution obtained in step (3) into a pH=8.0 polyethylene glycol phosphate buffer solution by spraying, ultrasonically disperse for 30 minutes, and centrifuge at 8000 rpm to obtain a white precipitate: the ...

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Abstract

The invention provides a method for preparing honeycomb mesoporous silica microspheres. The method comprises the following steps: adding a surfactant and potassium chloride into deionized water, and stirring to obtain a uniform surfactant solution; adding a hydrochloric acid solution to obtain an acidic surfactant solution; adding tetraethyl orthosilicate into the obtained acidic surfactant solution, and stirring at room temperature to obtain a clarified transparent solution; adding the obtained clarified transparent solution into a polyethylene glycol phosphate buffer solution in a spraying manner, then performing magnetic stirring or ultrasonic dispersion, performing centrifugal separation to obtain a white precipitate, and washing with deionized water and ethanol; drying the obtained white precipitate to obtain white powder; placing the white powder in a muffle furnace, and performing heat treatment to obtain the honeycomb mesoporous silica microspheres. The honeycomb mesoporous silica prepared with a sol-gel method in the invention has the pore size of 2-5nm and the specific surface area of 900-1400m<2> / g.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a mesoporous material, in particular to a method for preparing a honeycomb mesoporous silica microsphere. Background technique [0002] As an inorganic material, mesoporous silica has a large specific surface area and high porosity, and at the same time has the advantages of excellent chemical stability, non-toxicity, hydrophilicity, and easy modification of surface hydroxyl groups. occupies an important position. Especially as a carrier of all things, it can absorb more drug molecules in the channel, encapsulate the drug in the mesoporous channel, reduce the loss of the drug in the process of delivery in the body, and the channel can play a role in slow release, prolonging the drug in the human body. The preparation of silica is basically based on the Stober method under alkaline conditions through the hydrolysis and polycondensation of ethyl orthosilicate to prepare silica micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18
CPCC01B33/18C01P2002/82C01P2004/03C01P2004/04C01P2004/32C01P2004/62C01P2006/16
Inventor 单晓茜秦玉杰韩宇靳行
Owner SHANGHAI INST OF TECH
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