Thermosensitive three-stage color-changing medical antipyretic patch and preparation method thereof

A heat-reducing sticker and heat-sensitive technology, applied in the field of medical devices, can solve problems such as inability to effectively highlight low-grade and high-grade fever, difficult preservation of heat-sensitive materials, changes in physical and chemical properties, etc. The effect of breathability

Inactive Publication Date: 2019-01-18
江西润丰药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the color-changing antipyretic stickers currently on the market can only change two colors, that is, they can only distinguish between fever and no fever, and cannot effectively highlight low-grade fever and high-grade fever. The treatment options for low-grade and high-grade fever are very different, especially For special populations such as infants, in order not to affect their normal growth and development, it is generally not recommended to use drugs unless it is absolutely necessary. Therefore, it is more practical to develop a three-level ...

Method used

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  • Thermosensitive three-stage color-changing medical antipyretic patch and preparation method thereof

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Effect test

Embodiment 1

[0028] A heat-sensitive three-level color-changing medical antipyretic patch, including a spunlace non-woven fabric base cloth, a heat-sensitive hydrogel layer and a PP isolation film, the heat-sensitive hydrogel is coated on the spunlace non-woven fabric base fabric, and then laminated The PP isolation film can be obtained; among them, the heat-sensitive hydrogel layer directly contacts the human skin, absorbs the heat of the human body in the colloid, and then quickly evaporates the large amount of water stored in the hydrogel to take away the heat in the body, thereby reducing the temperature effect;

[0029] A preparation method of heat-sensitive three-stage color-changing medical antipyretic patch:

[0030] 1) By weight, weigh 0.5 part of the mixture of crystal violet lactone, fatty alcohol, and hydrated cobalt salt in a weight ratio of 0.5:4:1, and myristic acid, palmitic acid, and stearic acid in a weight ratio of 1:1: 1 part of the mixture of 2.5, 10 parts of polyviny...

Embodiment 2

[0033] A preparation method of heat-sensitive three-stage color-changing medical antipyretic patch:

[0034]1) By weight, weigh 0.3 parts of a mixture of crystal violet lactone, fatty alcohol, and hydrated cobalt salt in a weight ratio of 0.1:5:0.5, myristic acid, palmitic acid, and stearic acid in a weight ratio of 1:1: 1.6 parts of the mixture of 2.5, 3 parts of polyvinyl alcohol, dissolved in anhydrous alcohol, heated to 80°C and stirred continuously to allow it to react for 20 minutes, cooled with water to below 30°C, crystallized for 2 hours, suction filtered, and the filter residue was collected. Standby; mix and dissolve 10 parts of styrene, 3 parts of hydroxyethylacrylamide, and 0.5 parts of polyoxyethylene sorbitan monolaurate in water, stir at 45°C for 40 minutes to emulsify, and then add azobisisobutyl 0.1 part of amidine hydrochloride, heated to 80°C under stirring conditions, added the above filter residue at a rate of 0.5g / min, kept warm for 2 hours, then cooled ...

Embodiment 3

[0038] A preparation method of heat-sensitive three-stage color-changing medical antipyretic patch:

[0039] 1) By weight, weigh 0.8 parts of a mixture of crystal violet lactone, fatty alcohol, and hydrated cobalt salt in a weight ratio of 1:3:2, and myristic acid, palmitic acid, and stearic acid in a weight ratio of 1:1: 0.3 parts of the mixture of 2.5, 15 parts of polyvinyl alcohol, dissolved in anhydrous alcohol, heated to 70°C and stirred continuously to allow it to react for 20 minutes, cooled with water to below 30°C, crystallized for 1 hour, suction filtered, and the filter residue was collected. Standby; 1 part of styrene, 1 part of a mixture of divinylbenzene and methylol acrylamide, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitol Mix and dissolve 0.1 part of anhydride monooleate mixture in water, stir at 40-55°C for 40 minutes to emulsify, then add azobisisobutylamidine hydrochloride, azobisisobutylimidazoline h...

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Abstract

The invention discloses a novel medical antipyretic patch, in particular to a thermosensitive three-stage color-changing medical antipyretic patch and a preparation method thereof, wherein the thermosensitive three-stage color-changing medical antipyretic patch can directly observe the temperature change of a human body according to the color change in the use process. The antipyretic patch comprises a spunlace nonwoven substrate, a thermosensitive hydrogel layer and a PP separating film, wherein the thermosensitive hydrogel is coated on the spunlace nonwoven substrate, and then the PP separating film is coated on the thermosensitive hydrogel. The invention uses the mixture of crystal violet lactone, fatty alcohol and hydrated cobalt salt as the leuco dye, the mixture of tetradecanoic acid, hexadecanoic acid and stearic acid as the electron acceptor material, and optimizes the proportion of the components to effectively improve the color-changing sensitivity of the thermosensitive material; By adding carrageenan, konjac gum and nano-silica into hydrogel, the permeability and mechanical properties of hydrogel can be effectively improved, and the practicability is stronger.

Description

technical field [0001] The invention relates to a new type of medical antipyretic patch, in particular to a heat-sensitive three-stage color-changing medical antipyretic patch that can visually observe the change of human body temperature according to the change of color during use, and belongs to the technical field of medical devices. Background technique [0002] Children's fever is one of the main symptoms that threaten children's health, especially low-grade fever in young children. On the one hand, it is difficult for young children to express their subjective feelings. On the other hand, low-grade fever is often easily overlooked due to factors such as the environment. The delay of the disease will affect the normal development of the child at the slightest, and will cause life-threatening to the child at the worst; The color change of the patient can understand the patient's physical condition, and on the other hand, it can quickly cool down for treatment. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61F7/02A61B5/01
CPCA61B5/01A61F7/02A61F2007/0002A61F2007/0068A61F2007/0226
Inventor 朱小洪
Owner 江西润丰药业有限公司
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