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Novel bilayer membrane for guiding bone regeneration and preparation method thereof

A bone tissue regeneration and double-layer membrane technology, applied in coatings, medical science, prostheses, etc., can solve problems such as poor performance, easy collapse, and rapid degradation in the body, and achieve favorable prices, simple operation methods, and benefits for cells. Effects of ingrowth and soft tissue healing

Inactive Publication Date: 2019-01-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a new double-layer film for guiding bone tissue regeneration, which solves the technical defects of the traditional collagen film, such as poor mechanical properties, easy collapse, and too fast degradation in the body, and has good biocompatibility, which is conducive to cell growth and soft tissue healing

Method used

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  • Novel bilayer membrane for guiding bone regeneration and preparation method thereof
  • Novel bilayer membrane for guiding bone regeneration and preparation method thereof
  • Novel bilayer membrane for guiding bone regeneration and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] A novel bilayer membrane for guiding bone tissue regeneration, including a bilayer membrane prepared from type I collagen and polycaprolactone, and a nanoscale zeolite imidazolate framework material-8 coating coated on the bilayer membrane.

[0037] The preparation method of the novel guided bone tissue regeneration double-layer membrane is as follows:

[0038]S1) Preparation of double-layer membrane: Weigh type I collagen and polycaprolactone, and dissolve them in hexafluoroisopropanol to prepare the mass of solute according to the mass ratio of type I collagen and polycaprolactone at a ratio of 1:1 The first mixed spinning solution with a fraction of 7.5% was dissolved in hexafluoroisopropanol according to the mass ratio of type I collagen and polycaprolactone at a ratio of 1:1.5 to prepare the second mixed spinning solution with a solute mass fraction of 7.5%. Mix the spinning solution, stir it magnetically for 8 hours, draw 20ml of 1:1 first mixed spinning solution ...

Embodiment 2

[0042] The preparation method of the novel guided bone tissue regeneration double-layer membrane is as follows:

[0043] S1) Preparation of double-layer membrane: Weigh type I collagen and polycaprolactone, and dissolve them in hexafluoroisopropanol to prepare the mass of solute according to the mass ratio of type I collagen and polycaprolactone at a ratio of 1:1 The first mixed spinning solution with a fraction of 8.5% was dissolved in hexafluoroisopropanol according to the mass ratio of type I collagen and polycaprolactone at a ratio of 1:1.5 to prepare the second mixed spinning solution with a solute mass fraction of 8.5%. Mix the spinning solution, stir it magnetically for 12 hours, draw out 20ml of 1:1 first mixed spinning solution with two syringes, fix it on the constant current pump, connect the positive pole of the high-voltage electrostatic generator to the needle, and connect the negative pole to the To the receiving plate, a layer of aluminum foil paper is laid on ...

Embodiment 3

[0047] S1) Preparation of double-layer membrane: Weigh type I collagen and polycaprolactone, and dissolve them in hexafluoroisopropanol to prepare the mass of solute according to the mass ratio of type I collagen and polycaprolactone at a ratio of 1:1 The first mixed spinning solution with a fraction of 8% was dissolved in hexafluoroisopropanol according to the mass ratio of type I collagen and polycaprolactone at a ratio of 1:1.5 to prepare the second mixed spinning solution with a mass fraction of solute of 8%. Mix the spinning solution and stir it magnetically for 10 hours. First, use two syringes to draw 20ml of 1:1 first mixed spinning solution, fix it on the constant current pump, connect the positive pole of the high-voltage electrostatic generator to the needle, and connect the negative pole to the needle. To the receiving plate, a layer of aluminum foil paper is laid on the receiving plate to receive the electrospun fiber, the injection flow rate is set to 0.25ml / h, th...

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Abstract

The invention discloses a novel bilayer membrane for guiding bone regeneration and a preparation method thereof. The bilayer membrane comprises a double-layer membrane prepared by type I collagen andpolycaprolactone and a nano-scale zeolite imidazole ester skeleton material coated on the double-layer membrane. 8 coating, the preparation method comprises the following steps: S1) preparing a two-layer film; S2) drying and disinfecting; S3) coating a nano-scale zeolite imidazole ester skeleton material-8 coating. The invention solves the technical defect that the traditional collagen membrane has poor mechanical properties and collapses easily, and the degradation in the body is too fast, has good biocompatibility, and is beneficial to cell growth and soft tissue healing.

Description

technical field [0001] The field of oral medical materials of the present invention, specifically, relates to a novel dual-layer film for guiding bone tissue regeneration and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, more and more patients begin to consider implant restoration to restore dentition defect or missing dentition, and then restore mastication, pronunciation function and aesthetics. In implant repair, sufficient bone mass is the guarantee for successful implant surgery, and guided bone regeneration (guided bone regeneration GBR) technology is to implant bone graft materials in areas with insufficient bone mass, and cover the surface with guided bone regeneration membrane Acts as a physical barrier, preventing faster growing epithelial cells and fibroblasts from growing in and providing space for slower growing bone tissue and blood vessels. Guided bone tissue regeneration membranes are divided i...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/02A61L27/18A61L27/30A61L27/24A61L27/58
CPCA61L27/18A61L27/24A61L27/306A61L27/58C08L67/04C08L89/00
Inventor 万乾炳薛轶元王剑裴锡波游伦陈俊宇王通秦汉程馨霆
Owner SICHUAN UNIV
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