Method for producing levodopa from Mucuna

Abstract

The invention discloses a method for producing levodopa from Mucuna, belonging to the technical field of deep processing of Mucuna. The method comprises the following steps of processing Mucuna to obtain Mucuna powder, dissolving vitamin C and acetic acid into water, adding Mucuna powder and mixing uniformly, performing ultrasonic extraction, and then performing refluxing extraction for three times; uniformly mixing the filtrates which are obtained through three extractions, adjusting the pH to 4-5, standing still and precipitating to obtain extracting solution; centrifugally separating the extracting solution, concentrating the supernatant to obtain crude product; refining, drying, crushing, mixing and packaging the crude product to obtain levodopa product. The levodopa prepared by the invention is high in yield and purity, lower in cost of extraction method in comparison with traditional craft, and the cost is close to the cost for blending levodopa with a low concentration. By adopting the method provided by the invention, nearly zero wastewater discharge is realized, and moreover, mother solution and precipitate can be used for producing extracts with different contents, the whole process can produce series products with active component extracts from 10-99 percent, and meanwhile, the demands of different customers can be met, and the product sales volume is guaranteed.

Description

technical field [0001] The invention belongs to the technical field of deep processing of quinoa beans, and in particular relates to a method for producing levodopa from quinoa beans. Background technique [0002] Quinoa bean is a cultivated species of young pods and seeds in the leguminous genus Chenopodium. It is an annual winding herbaceous plant. Quinoa beans are rich in protein, vitamins, and inorganic salts. You can harvest tender pods or seeds for vegetable consumption. [0003] Levodopa is one of the precursors for the synthesis of norepinephrine and dopamine in the body, which can increase the level of dopamine in the brain tissue. It is an important biologically active substance in the body. important intermediates in biochemical metabolic pathways. Levodopa is mainly used for men's health care. It has the functions of aphrodisiac, fitness, prevention and improvement of Parkinson's syndrome, and is widely used in the market. At present, levodopa products are mad...

AI Technical Summary

Problems solved by technology

The more prominent problem of the acid water-resin method is that the extraction process consumes a large amount of hydrochloric acid, which requires particularly high acid resistance of the equipment, resulting in short service life of the equipment, quick update, and high production costs; another obvious disadvantage of the acid water-resin method is : The production process produces a large amount of acidic wastewater, and after neutralization, a large amount of protein precipitates are precipitated. The COD is as high as 10,000 mg / L, which seriously exceeds the national discharge standard of COD less than 100 mg / L. Therefore, this type of sewage treatment facility requires large investment and environmental protection. The cost is extremely high, the pressure on environmental protection increases, and the product cost is high

The disadvantage is that after the particles and colloidal ions in the extract are adsorbed and deposited on the membrane surface or in the membrane pores to a certain extent, the membrane pores are quickly blocked and become smaller, and the permeation flow and separation characteristics of the membrane are irreversibly changed. Phenomenon, the membrane permeability and transmittance are almost 0, and the membrane needs to be regenerated frequently, so that the service life of the filter membrane is very short, and the filter membrane needs to be updated frequently, and the cost is very high

But this method has the following disadvantages: the pH adjusted by the extract is 5.5-8, and finally there will be about 5% of acid-base wastewater to be discharged, and more components such as ammonium bicarbonate, ammonium sulfate, and tannin are added in the extraction process Acid, sodium metabisulfite, etc., increase the cost and cause some pollution to the environment; cat beans are extracted after being flattened, and cannot obtain levodopa to a greater extent, and the product yield is only 3-3.5%, which needs to be improved

[0007] At present, the processing and production of levodopa by quinoa beans generally has defects such as complicated procedures, low extraction rate, low purity of levodopa, and high cost.

Due to the particularity of the extraction of lentil beans, the current production cost of levodopa from quinoa beans remains high and cannot compete with low-content levodopa that is chemically synthesized or blended with high-content levodopa and starch. The pharmacological effect of the extract is obviously better than blended dopa, but because of its extremely high price, it affects sales and cannot fully open up the market

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