Method for producing levodopa from Mucuna

A technology of levodopa and quinoa beans, applied in the field of levodopa production from quinoa beans, can solve the problems of increased pressure on environmental protection, low extraction rate, short equipment life, etc., to ensure product sales, high product yield, and water consumption little effect

Active Publication Date: 2019-01-18
那坡康正天然植物提取有限责任公司
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The more prominent problem of the acid water-resin method is that the extraction process consumes a large amount of hydrochloric acid, which requires particularly high acid resistance of the equipment, resulting in short service life of the equipment, quick update, and high production costs; another obvious disadvantage of the acid water-resin method is : The production process produces a large amount of acidic wastewater, and after neutralization, a large amount of protein precipitates are precipitated. The COD is as high as 10,000 mg/L, which seriously exceeds the national discharge standard of COD less than 100 mg/L. Therefore, this type of sewage treatment facility requires large investment and environmental protection. The cost is extremely high, the pressure on environmental protection increases, and the product cost is high
The disadvantage is that after the particles and colloidal ions in the extract are adsorbed and deposited on the membrane surface or in the membrane pores to a certain extent, the membrane pores are quickly blocked and become smaller, and the permeation flow and separation characteristics of the membrane are irreversibly changed. Phenomenon, the membrane permeability and transmittance are almost 0, and the membrane needs to be regenerated frequently, so

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for producing levodopa from Mucuna

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for producing levodopa from quinoa beans, comprising the steps of:

[0032] S1. Treatment of quinoa beans: Clean the quinoa beans, grind them into powder, and pass through an 80-mesh sieve to obtain quinoa bean powder.

[0033] S2, leaching: add vitamin C, acetic acid to dissolve in water, also added table salt simultaneously, the add-on of described table salt is 0.08% of water weight, add quinoa bean powder and mix again, described quinoa bean powder, water, vitamin C. The mass ratio of acetic acid is: quinoa bean flour: water: vitamin C: acetic acid = 1:5:0.005:0.005; ultrasonic extraction is 45min, ultrasonic power is 400W, working temperature is 75°C; then reflux extraction for 8h to complete the first immersion , filter; take the filter residue and carry out the second immersion according to the method of first immersion, and filter; take the filter residue and perform three immersion according to the method of first immersion, wherein the reflux extracti...

Embodiment 2

[0039] A method for producing levodopa from quinoa beans, comprising the steps of:

[0040] S1. Treatment of quinoa beans: Clean the quinoa beans, grind them into powder, and pass through an 80-mesh sieve to obtain quinoa bean powder.

[0041]S2, leaching: add vitamin C, acetic acid into water to dissolve, also added table salt simultaneously, the add-on of described table salt is 0.06% of water weight; C. The mass ratio of acetic acid is: quinoa bean flour: water: vitamin C: acetic acid = 1: 6: 0.005: 0.006; ultrasonic extraction is 40 minutes, ultrasonic power is 450W, working temperature is 75 ° C; then reflux extraction for 9 hours, complete a dip , filter; take the filter residue and carry out the second immersion according to the method of first immersion, and filter; take the filter residue and perform three immersion according to the method of first immersion, wherein the reflux extraction time is changed to 3.5h, filter, and the filter residue is recycled for fermenti...

Embodiment 3

[0047] A method for producing levodopa from quinoa beans, comprising the steps of:

[0048] S1. Treatment of quinoa beans: Clean the quinoa beans, grind them into powder, and pass through an 80-mesh sieve to obtain quinoa bean powder.

[0049] S2, leaching: add vitamin C, acetic acid to dissolve in water, also added table salt simultaneously, the add-on of described table salt is 0.08% of water weight, then add quinoa bean powder and mix, described quinoa bean powder, water, vitamin C. The mass ratio of acetic acid is: quinoa bean flour: water: vitamin C: acetic acid = 1:5:0.004:0.005; ultrasonic extraction is 50min, ultrasonic power is 350W, working temperature is 75°C; then reflux extraction for 8h, complete a dip , filter; take the filter residue and carry out the second immersion according to the method of first immersion, and filter; take the filter residue and perform three immersion according to the method of first immersion, wherein the reflux extraction time is change...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for producing levodopa from Mucuna, belonging to the technical field of deep processing of Mucuna. The method comprises the following steps of processing Mucuna to obtain Mucuna powder, dissolving vitamin C and acetic acid into water, adding Mucuna powder and mixing uniformly, performing ultrasonic extraction, and then performing refluxing extraction for three times; uniformly mixing the filtrates which are obtained through three extractions, adjusting the pH to 4-5, standing still and precipitating to obtain extracting solution; centrifugally separating the extracting solution, concentrating the supernatant to obtain crude product; refining, drying, crushing, mixing and packaging the crude product to obtain levodopa product. The levodopa prepared by the invention is high in yield and purity, lower in cost of extraction method in comparison with traditional craft, and the cost is close to the cost for blending levodopa with a low concentration. By adopting the method provided by the invention, nearly zero wastewater discharge is realized, and moreover, mother solution and precipitate can be used for producing extracts with different contents, the whole process can produce series products with active component extracts from 10-99 percent, and meanwhile, the demands of different customers can be met, and the product sales volume is guaranteed.

Description

technical field [0001] The invention belongs to the technical field of deep processing of quinoa beans, and in particular relates to a method for producing levodopa from quinoa beans. Background technique [0002] Quinoa bean is a cultivated species of young pods and seeds in the leguminous genus Chenopodium. It is an annual winding herbaceous plant. Quinoa beans are rich in protein, vitamins, and inorganic salts. You can harvest tender pods or seeds for vegetable consumption. [0003] Levodopa is one of the precursors for the synthesis of norepinephrine and dopamine in the body, which can increase the level of dopamine in the brain tissue. It is an important biologically active substance in the body. important intermediates in biochemical metabolic pathways. Levodopa is mainly used for men's health care. It has the functions of aphrodisiac, fitness, prevention and improvement of Parkinson's syndrome, and is widely used in the market. At present, levodopa products are mad...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C229/36C07C227/40C07C227/28
CPCC07C227/28C07C227/40C07C229/36
Inventor 黎永红陆华黎敏护
Owner 那坡康正天然植物提取有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products