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A kind of X-ray-opaque marker barium sulfate pellets and preparation method thereof

A technology of barium sulfate and markers, applied in X-ray contrast agent preparation, microcapsules, pharmaceutical formulations, etc., can solve the problem of reducing the accuracy of colon transit test in diagnosing constipation disease types, affecting the determination of patient treatment methods, and colon transit test results Inaccurate and other problems, to achieve the effect of promoting the healthy development of the society, promoting the application, improving the quality of diagnostic services, and having no potential safety hazards

Active Publication Date: 2021-12-03
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is that in the prior art, when barium sulfate or its preparation is used as a marker in the colon transit test, the stability is poor, and the developing effect is not good, resulting in inaccurate results of the colon transit test. Accurate, reducing the accuracy of the colonic transit test in diagnosing the type of constipation disease, affecting the determination of the follow-up treatment method of the patient, increasing the suffering of the patient, and the preparation method of the existing barium sulfate preparation is complicated and not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1, preparation of barium sulfate pellets

[0073] The raw materials for preparing the ball core include: 126g of barium sulfate, 34.2g of microcrystalline cellulose, and 18g of lactose;

[0074] The raw materials for preparing the coating include: 162g of barium sulfate, 7.2g of microcrystalline cellulose, and 0.9g of lactose;

[0075] The raw materials for preparing the coating layer include: 3% ethyl cellulose ethanol solution;

[0076] The preparation method specifically includes:

[0077] Take 1 part of the raw materials for the preparation of the above-mentioned ball core, mix them evenly, pass through a 100-mesh sieve, use hypromellose solution to make it into a soft material, put it into an extrusion spheronizer, and make a strip of a certain length, and further The strips are rounded, passed through a 8-20 mesh sieve, and dried in a blast drying oven at 60°C for 2 hours to obtain the core of the barium sulfate pellets;

[0078] Take 3.5 parts of th...

Embodiment 2

[0080] Embodiment 2, preparation of barium sulfate pellets

[0081] The raw materials for preparing the ball core include: 144g of barium sulfate, 21.6g of microcrystalline cellulose, and 12.6g of lactose;

[0082] The raw materials for preparing the coating include: 153g of barium sulfate, 18g of microcrystalline cellulose, and 7.2g of lactose;

[0083] Coating layer preparation raw materials include: 3% ethyl cellulose ethanol solution

[0084] The preparation method specifically includes:

[0085] Take 1 part of the raw materials for the preparation of the above-mentioned ball core, mix them evenly, pass through a 100-mesh sieve, use hypromellose solution to make it into a soft material, put it into an extrusion spheronizer, and make a strip of a certain length, and further The strips are rounded, passed through a 10-16 mesh sieve, and dried in a blast drying oven at 60°C for 2 hours to obtain the core of the barium sulfate pellets;

[0086] Take 4 parts of the raw mater...

Embodiment 3

[0088] Embodiment 3, preparation of barium sulfate pellets

[0089] The raw materials for preparing the ball core include: 153g of barium sulfate, 18g of microcrystalline cellulose, and 1.8g of lactose;

[0090] The raw materials for preparing the coating layer include: 168.3g of barium sulfate, 9g of microcrystalline cellulose, and 0.9g of lactose;

[0091] Coating layer preparation raw materials include: 3% ethyl cellulose ethanol solution

[0092] The preparation method specifically includes:

[0093] Take 1 part of the raw materials for the preparation of the above-mentioned ball core, mix them evenly, pass through a 100-mesh sieve, use hypromellose solution to make it into a soft material, put it into an extrusion spheronizer, and make a strip of a certain length, and further The strips are rounded, passed through a 10-16 mesh sieve, and dried in a blast drying oven at 60°C for 2 hours to obtain the core of the barium sulfate pellets;

[0094] Take 5 parts of the raw m...

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Abstract

The invention discloses an X-ray-opaque marker barium sulfate pellet, which comprises a pellet core, a barium sulfate wrapping layer and a coating layer. The particle diameter of the barium sulfate pellet is 6-7 meshes. agent, adhesive, the barium sulfate coating layer is the feed powder and adhesive including barium sulfate and diluent, the feed powder is attached or wrapped on the outer layer of the ball core, and the coating layer includes slow-release materials. The invention also provides the preparation method and application of the barium sulfate pellets. When the barium sulfate pellets disclosed in the present invention are used in the colon transit test to diagnose the type of constipation disease, the stability is good, the development is clear and the effect is good, the accuracy of the results of the colon transit test is improved, and it is beneficial to the accurate diagnosis of the constipation disease type. Improve the matching accuracy of the patient's follow-up treatment method, reduce the patient's pain of delayed disease treatment due to diagnostic errors; the preparation method of the barium sulfate pellets disclosed by the invention is simple, easy to operate, safe and environmentally friendly, and is conducive to the realization of industrialization and expanded production and application.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an X-ray-opaque marker barium sulfate pellet and a preparation method thereof. Background technique [0002] Slow transit constipation is a common chronic gastrointestinal disease in clinical practice. Due to changes in dietary structure, mental stress, population aging and social factors, its incidence is increasing year by year. At present, the adult prevalence rate in my country is 4% to 6%. Slow transit constipation can often lead to hemorrhoids, anal fissure and other anorectal diseases, increase the risk of colon cancer, hepatic encephalopathy, Alzheimer's disease, etc., and can also induce acute cardiovascular and cerebrovascular accidents, resulting in death of patients and increasing the economic benefits of patients. and psychological burden. Therefore, it is very urgent to make a reasonable diagnosis and treatment of slow transit constipation. At...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K9/50A61K47/38
CPCA61K9/5042A61K49/0404
Inventor 谢英花宁芳崔玉李冬雪孟晗川马燕山
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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