Novel artificial bone material as well as preparation method and application thereof

A technology of artificial bone and bone material, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of poor biocompatibility and high modulus of PMMA bone cement, and achieve low elastic modulus, good biocompatibility, The effect of reducing PMMA bone cement complications

Inactive Publication Date: 2019-02-12
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to improve the problems of high modulus and poor biocompatibility of PMMA bone cement, the object of the present invention is to provide a novel artificial bone material

Method used

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  • Novel artificial bone material as well as preparation method and application thereof
  • Novel artificial bone material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 modified mineralized collagen

[0036] Step S1, dissolving collagen in any one of hydrochloric acid, nitric acid or acetic acid to prepare an acid solution of collagen, wherein the concentration of collagen is 5.0×10-5~5.0×10-3 g / mL;

[0037] Step S2, continuously stirring the solution obtained in step S1, slowly adding the solution containing calcium ions dropwise, the amount of calcium ions added is 0.01-0.16 mol of calcium ions corresponding to each gram of collagen;

[0038] Step S3, continuously stirring the solution obtained in step S2, slowly adding the solution containing phosphate ions dropwise, the molar ratio of the amount of phosphate ions added to the amount of calcium ions added in step S2 is Ca / P=1 / 1~2 / 1;

[0039] Step S4, continue to stir the solution obtained in step S3, slowly add NaOH solution dropwise until the pH of the mixed system is 6-8, when the pH=5-6, the mixed system begins to precipitate, and when the pH=7, th...

Embodiment 2

[0044] Embodiment 2 Preparation of modified mineralized collagen artificial bone material 1

[0045] The artificial bone material is a PMMA bone material of a two-component system, the two-component system is composed of a powder component and a liquid component, and the weight ratio of the powder component to the liquid component is 1:2.5;

[0046] Wherein, in the powder component, by weight, it includes 30 parts of modified mineralized collagen powder, 40 parts of polymethyl methacrylate powder, 10 parts of 1,3-butadiene powder, styrene powder 10 parts, 6 parts of strontium boride, 6 parts of magnesium nitrate, 7 parts of silver nitrate, the molecular weight is 2x10 5 ~3x10 5 12 parts of carboxymethyl chitosan;

[0047] The liquid part includes dimethyl terephthalate solution and methyl methacrylate solution, wherein the weight ratio of dimethyl terephthalate solution and methyl methacrylate solution is 1:60 , the mass fraction of dimethyl terephthalate in dimethyl tereph...

Embodiment 3

[0053] Embodiment 3 Preparation 2 of modified mineralized collagen artificial bone material

[0054] The artificial bone material is a PMMA bone material of a two-component system, the two-component system is composed of a powder component and a liquid component, and the weight ratio of the powder component to the liquid component is 1:3;

[0055] Wherein, in the powder component, by weight, it includes 35 parts of modified mineralized collagen powder, 30 parts of polymethyl methacrylate powder, 12 parts of 1,3-butadiene powder, styrene powder 14 parts, 11 parts of strontium boride, 12 parts of magnesium nitrate, 8 parts of silver nitrate, the molecular weight is 2x10 5 ~3x10 5 15 parts of carboxymethyl chitosan;

[0056] The liquid part includes dimethyl terephthalate solution and methyl methacrylate solution, wherein the weight ratio of dimethyl terephthalate solution and methyl methacrylate solution is 1:60 , the mass fraction of dimethyl terephthalate in dimethyl tereph...

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Abstract

The invention discloses a novel artificial bone material. The artificial bone material is a PMMA bone material in a double-component system; the double-component system consists of a powder componentand a liquid component; the weight ratio of the powder component to the liquid component is 1:(2.5 to 4.5). The invention also provides a preparation method and application of the artificial bone material. The artificial bone material with high compressive strength, low elasticity modulus and high biocompatibility is obtained. In the aspect of mechanical performance, the novel material combines the mechanical property of the human bone tissue compared with pure PMMA bone cement; the risk that the autogenous bone is worn is reduced; the damage due to extrusion when the prosthesis is implanted can also be effectively avoided. In the aspect of biocompatibility, the modified mineralized collagen composite material can form bone combination with the autogenous bone; the bone bonding and the stability of a filler in the implanted position are favorably improved, so that the use of the novel material is safer and more reliable.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a novel artificial bone material and its preparation method and application. Background technique [0002] Bone cement is a medical material widely used in orthopedic surgery. Bone cement is usually composed of solid powder and curing liquid. It can be cured by mixing it in a certain proportion at room temperature. After the reaction is over, the joint can be fixed or the bone defect can be repaired. Due to the injectability of bone cement, it can minimize the area of ​​minor surgical wounds, speed up the recovery, and reduce the pain of patients. Therefore, it is often used as a filling material and scaffold material for bone tissue, which plays a supporting role and is an indispensable material for bone tissue applications. a member of Since the advent of bone cement in the early 1960s, the main types of bone cement are polymethyl methacrylate (PMMA) bone cement, ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/16A61L27/20A61L27/24A61L27/50
CPCA61L27/025A61L27/16A61L27/20A61L27/24A61L27/50A61L2430/02C08L33/12C08L5/08
Inventor 翁习生边焱焱张嘉郑志博李涛
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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