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Sulfonated dihydroxypropyl chitosan modified polysulfone (SDHPCS-PSF) membrane and preparation method thereof

A technology of sulfonated dihydroxypropyl chitosan and polysulfone membrane, which is applied in the field of biomedical materials, can solve the problems of expensive heparin, poor molecular specificity of heparin, and limitation of clinical application of heparin-grafted polysulfone, achieving the degree of aggregation and The degree of deformation is reduced, the reaction conditions are mild and easy to control, and the effect of improving blood compatibility

Inactive Publication Date: 2019-02-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, heparin has poor molecular specificity and is easy to combine with other proteins, especially platelet factors, thereby inducing thrombocytopenia. In addition, heparin also has side effects such as inducing hemorrhage and hyperkalemia. Clinical applications of sulfone surfaces

Method used

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  • Sulfonated dihydroxypropyl chitosan modified polysulfone (SDHPCS-PSF) membrane and preparation method thereof
  • Sulfonated dihydroxypropyl chitosan modified polysulfone (SDHPCS-PSF) membrane and preparation method thereof
  • Sulfonated dihydroxypropyl chitosan modified polysulfone (SDHPCS-PSF) membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Immerse the polysulfone-based membrane in 0.4moL / L 2,4-dihydroxybenzophenone methanol solution for 1h; take out the polysulfone-based membrane or leave it in the original solution, and irradiate it with a 160W UV lamp for 5min to obtain hydroxylation Polysulfone base membrane;

[0044] Add the hydroxylated polysulfone-based membrane to vinyl glycidyl ether, control the temperature at 50°C, and stir for 2 hours; after taking it out, wash it with absolute ethanol and deionized water, and then dry it under vacuum at 45°C to obtain ethylene Kylated polysulfone base membrane;

[0045] Add 1g of the SDHPCS obtained above into 45mL of deionized water, stir evenly, and make an SDHPCS aqueous solution; then add 5mL of potassium persulfate solution with a mass fraction of 5%, and then add the vinylated polysulfone-based membrane obtained above. Under the protection of nitrogen, stir and react at room temperature for 20 hours; after the reaction, wash the membrane with deionized ...

Embodiment 2

[0047] Immerse the polysulfone-based membrane in 0.4moL / L 2,4-dihydroxybenzophenone methanol solution for 40min; take out the polysulfone-based membrane or leave it in the original solution, and irradiate it with a 180W UV lamp for 5min to obtain hydroxylation Polysulfone base membrane;

[0048] Add the hydroxylated polysulfone-based membrane to vinyl glycidyl ether, control the temperature at 50°C, and stir for 2 hours; after taking it out, wash it with absolute ethanol and deionized water, and then dry it under vacuum at 45°C to obtain ethylene Kylated polysulfone base membrane;

[0049] Add 2 g of the SDHPCS obtained above into 45 mL of deionized water, stir evenly, and make an SDHPCS aqueous solution; then add 5 mL of potassium persulfate solution with a mass fraction of 5%, and then add the vinylated polysulfone-based membrane obtained above. Under the protection of nitrogen, stir and react at room temperature for 20 hours; after the reaction, wash the membrane with deio...

Embodiment 3

[0051] Immerse the polysulfone-based membrane in 0.4moL / L 2,4-dihydroxybenzophenone methanol solution for 1h; take out the polysulfone-based membrane or leave it in the original solution, and irradiate it with a 200W UV lamp for 10min to obtain hydroxylation Polysulfone base membrane;

[0052] Add the hydroxylated polysulfone-based membrane to vinyl glycidyl ether, control the temperature at 50°C, and stir for 2 hours; after taking it out, wash it with absolute ethanol and deionized water, and then dry it under vacuum at 45°C to obtain ethylene Kylated polysulfone base membrane;

[0053] Add 2 g of the SDHPCS obtained above into 45 mL of deionized water, stir evenly, and make an SDHPCS aqueous solution; then add 5 mL of potassium persulfate solution with a mass fraction of 5%, and then add the vinylated polysulfone-based membrane obtained above. Under the protection of nitrogen, stir and react at room temperature for 20 hours; after the reaction, wash the membrane with deioni...

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Abstract

The invention relates to a sulfonated dihydroxypropyl chitosan modified polysulfone (SDHPCS-PSF) membrane and a preparation method thereof. The preparation method comprises the steps of anchoring 2,4-dihydroxybenzophenone (2,4-DHBP) onto the surface of a polysulfone (PSF) membrane, used as a base membrane, by means of ultraviolet grafting so as to obtain a hydroxylated PSF base membrane; graftingvinyl glycidyl ether onto the surface of the hydroxylated PSF base membrane by means of an etherification reaction so as to obtain a vinylated PSF base membrane; finally, grafting sulfonated dihydroxypropyl chitosan (SDHPCS) onto the surface of the vinylated PSF base membrane by means of a Michael addition reaction so as to obtain the SDHPCS-PSF membrane. The preparation method has the characteristic that the surface of the PSF membrane contains SDHPCS-PSF, so that the hydrophilia and anticoagulant activity of the membrane surface are improved; furthermore, the method is simple in process, andmild and controllable in reaction conditions.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a sulfonated dihydroxypropyl chitosan modified polysulfone membrane and a preparation method thereof. Background technique [0002] With the change of disease spectrum and the acceleration of population aging process, the incidence of chronic kidney disease worldwide is increasing year by year. The number of renal replacement therapy patients is increasing at a rate of more than 11% per year. Hemodialysis is one of the main treatments for patients with ESRD. Dialysis membrane is the core part of hemodialysis treatment, how to effectively avoid coagulation and thrombus formation on the membrane surface during dialysis has always been a crucial problem in the clinical use of hemodialyzers. Polysulfone is widely used in the preparation of dialysis membranes due to its high temperature resistance, good mechanical properties, and strong corrosion resistance. And because the pore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D67/00
CPCB01D67/0002B01D71/68
Inventor 邱运仁王灿闫升
Owner CENT SOUTH UNIV
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