Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparing method for tianeptine molecularly imprinted electrochemical sensor

A molecular and electrochemical technology of tianeptine, which is applied in the field of preparation of molecularly imprinted electrochemical sensors for tianeptine, can solve problems such as poor drop resistance, inability to properly match functional monomers and template molecules, and low sensitivity. question

Inactive Publication Date: 2019-02-12
GUANGXI UNIV FOR NATITIES
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method has low sensitivity and poor drop resistance because the selected functional monomers and template molecules cannot be properly matched, and the toughness and rigidity of the crosslinked film are also poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparing method for tianeptine molecularly imprinted electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Treatment of glassy carbon electrode

[0017] Polish the glassy carbon electrode on the polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder, then put it in a 1:1 volume ratio of nitric acid for 8 min, and then put it in absolute ethanol for 8 min , And finally clean with pure water ultrasonic cleaning.

[0018] 2. Preparation of tianeptine molecularly imprinted electrochemical sensor

[0019] Prepare 20 mL of a mixed aqueous solution of 0.25 mol / L cobalt sulfate, 0.25 mol / L nickel sulfate and 0.5 mol / L vitamin C with water as the solvent, and use benzyl alcohol as the solvent to prepare a concentration of 0.05 mol / L pentaerythritol 5 mL of distearyl diphosphite, and then add the prepared 5 mL of pentaerythritol diphosphite distearyl solution at a rate of 5 drops per second to the 20 mL of cobalt sulfate, nickel sulfate and vitamin C prepared above In the mixed solution, stir vigorously at a speed of 2500 rpm during the dripping process, and then react in a 50 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparing method for a tianeptine molecularly imprinted electrochemical sensor. A tianeptine molecularly imprinted electrochemical sensor with high-sensitivity and drop-resistant doped nickel-cobalt layered powder composite materials can be prepared by taking the tianeptine as a template molecule, taking the lithospermoside as a functional monomer, taking the azobisisobutyronitrile as an initiator, taking the nickel-cobalt layered powder composite material as a dopant, taking the 4-butoxyl-4'-cyanobiphenyl as a sensing membrane modifier, and taking the isoliquiritigenin as a crosslinking agent. The analyzing method is simple and practical, and the defects that the prior analyzing method is complex, the equipment is expensive, and the sensitivity is low are overcome.

Description

Technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a tianeptine molecularly imprinted electrochemical sensor. Background technique [0002] Tianeptine is an antidepressant. It is often used to treat depression and various anxiety and depression-based neuroses. It can also be used for menopausal psychosis, and is effective for depressive neurosis, chronic alcoholism and after alcoholism. Depression that appears is also effective. However, excessive use of such drugs can cause side effects such as drowsiness, dry mouth, blurred vision, upper abdominal pain, abdominal pain, kidney function, liver function damage, etc. caused by drug sensitivity. Therefore, it is listed as a controlled drug by most countries in the world. [0003] The methods for determination of Tianeptine include high performance liquid chromatography, chromatographic mass spectrometry and so on. However, these methods have disadva...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3275
Inventor 李浩余会成韦贻春石展望雷福厚陈其锋
Owner GUANGXI UNIV FOR NATITIES