Elemene-solid lipid nanoparticles and preparation method thereof
A technology of elemene and lipids, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low bioavailability, impact on popularization and application, pain, fever, etc. problems, achieve the effect of improving bioavailability, high safety, and good targeting
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Embodiment 1
[0031] The preparation of embodiment 1 elemene solid lipid nanoparticles
[0032] By prescription screening (partial screening experiment is described in embodiment 2), obtain more preferred prescription as follows:
[0033]
[0034] Each component of the recipe amount was weighed, glyceryl tristearate and glyceryl monostearate were mixed and melted in a water bath at 65° C. to obtain an oil phase. Weigh the prescribed amount of sodium cholate and dissolve it in double distilled water, and heat to 65°C to form an aqueous phase. Quickly disperse the elemene measured according to the prescription in the molten oil phase mixture, then quickly pour it into a glass tube, then add the water phase to the oil phase, and use an ultrasonic probe under the condition of a water bath with a temperature of 65°C on the outer layer The mixture was subjected to sonication (power: 360w), 10s of sonication followed by 10s of sonication, and the sonication time was 5min (including the stop time...
Embodiment 2
[0036] The prescription and preparation method are the same as in Example 1, except that sodium cholate is replaced by egg yolk lecithin, soybean lecithin and TPGS respectively. The experimental results found that the use of egg yolk lecithin produced floating flocs during the preparation process, and soybean lecithin produced precipitates when the temperature was lowered. Although TPGS has good stability, the particle size distribution of the product will produce bimodal .
[0037] The prescription and preparation method are the same as in Example 1, except that glyceryl tristearate is replaced by glyceryl stearate, stearic acid, glyceryl tripalmitate and glyceryl palmitate. The results of the experiment found that stearic acid and glyceryl palmitate began to precipitate after 17 hours after being placed at room temperature, while cholesterol stearate and glyceryl palmitate were more stable than the former, but remained stable after 32 hours. Precipitation occurs, still sign...
Embodiment 3
[0039] Preparation method is identical with embodiment 1, and prescription is changed into respectively:
[0040]
[0041] The stability of the prepared formulation was similar to that of Example 1, and the particle size and particle size distribution were 142 and 118, and 0.182 and 0.248, respectively. The encapsulation efficiencies were 97.45% and 97.77%, respectively, and the drug loadings were 39.9% and 39.11%.
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