A kind of coupling synthesis method of 4,4,4-trifluorobutanol

A technology of trifluorobutanol and cross-coupling reaction, applied in chemical instruments and methods, preparation of organic compounds, preparation of hydroxy compounds, etc., can solve the problems of low yield of synthetic routes, unfavorable industrialization and application, etc.
CN109384651BActive Publication Date: 2021-09-21湖南有色郴州氟化学有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
湖南有色郴州氟化学有限公司
Publication Date
2021-09-21

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Abstract

The invention provides a novel method for coupling and synthesizing 4,4,4-trifluorobutanol, comprising the following steps: in the presence of a catalyst, 2,2,2-trifluoro-1-chloroethane and 1-chloroethanol is mixed in a solvent to carry out cross-coupling reaction to obtain 4,4,4-trifluorobutanol; the catalyst is a copper salt and an organic ligand; the copper salt is cuprous halide and / or chlorine copper chloride; the organic ligand is one or more of 2,2'-bipyridine, tetramethylethylenediamine and 4,4-di-tert-butyl-2,2,-bipyridine. The present invention uses copper salts and organic ligands as catalysts to catalyze the free radical cross-coupling reaction between 2,2,2-trifluoro-1 haloethane and 1-chloroethanol, and can efficiently prepare 4,4,4- Trifluorobutanol, the preparation method in the present invention has high selectivity and high yield. Experimental results show that the yield of the preparation method in the present invention is as high as 80%.
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Description

technical field

[0001] The invention belongs to the technical field of organic fluorine fine chemicals, and in particular relates to a novel coupling synthesis method for synthesizing 4,4,4-trifluorobutanol. Background technique

[0002] 4,4,4-Trifluorobutanol is a widely used fluorine fine chemical. It is mainly used as a pharmaceutical raw material. It can be used to make antiseptics, antiemetics, and local analgesics. 10% ointment can be disinfected and sterilized, used as antiseptic, anesthetic, cosmetic preservative, and also an important raw material for many organic synthesis reactions. The following are the main operational routes of the synthetic trifluorobutanol reported in the literature at present:

[0003] The method for preparing trifluorobutanol is to use 1,1,1-trifluoropropane and ethyl orthoformate as raw materials, reflux reaction in ether solution for a long time to generate fluorinated aldehyde, and then reduce it with lithium aluminum sodium hydride to ...

Claims

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