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Method for extracting mangiferin from leaves of mangifera indica linn

A technology of mango leaves and mangiferin, which is applied in the extraction field of biotechnology, can solve the problems of safety impact, deep color, long production cycle, etc., and achieve high-efficiency cell wall breaking, uniform particle size distribution, and reduce color.

Inactive Publication Date: 2019-03-08
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN100475830C "preparation method of high-purity mangiferin", patent CN101759689A "preparation method of mangiferin" and patent CN101429222A "a method of extracting mangiferin" all adopt macroporous resin purification as the main separation step, however The macroporous resin purification method is adopted, the resin needs to be treated before use, the purification needs to go through the process of adsorption and elution, and the production cycle is long
When using a macroporous resin for purification and elution, due to physical adsorption, it is easy to cause a part of the sample to be deadly adsorbed, resulting in a decrease in the transfer rate
In addition, the volume of eluent purified by macroporous resin is large, and the solvent recovery time is long, which increases the production cost, and the solvent recovery produces more waste liquid, which causes a certain burden on environmental protection.
In addition, due to the use of macroporous resins, the risk of introducing organic residual solvents such as benzene, toluene, xylene, styrene, alkanes, and diethylbenzene has increased, which has a certain impact on product safety.
[0005] In existing studies, for the extraction of mangiferin from mango leaves, generally the content of mangiferin can reach more than 98.5%, but the color of mangiferin obtained in the prior art is relatively dark, which is not conducive to the subsequent utilization of mangiferin

Method used

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  • Method for extracting mangiferin from leaves of mangifera indica linn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for extracting mangiferin from mango leaves, specifically comprising the steps of:

[0024] 1) Raw material processing: crushing dried mango leaves;

[0025] 2) High-pressure micro-jet ultra-fine pulverization treatment: Add equal weight of pure water to the material obtained in the previous step, and then add petroleum sodium sulfonate equivalent to 0.3% of the material weight, and process it with a high-speed shear emulsifier for 10 minutes at a speed of 8000r / min, then process it at 25°C with high-pressure micro-jet ultrafine pulverization equipment, the processing pressure is 80MPa, and the number of times of processing is 2 times to obtain a paste slurry;

[0026] 3) Separation: perform two-phase extraction on the obtained paste slurry to obtain the upper extraction phase and the lower extraction phase. The two-phase aqueous system used in the two-phase extraction is composed of polyethylene glycol, sodium carbonate and water. The poly The mass percentag...

Embodiment 2

[0030] A method for extracting mangiferin from mango leaves, specifically comprising the steps of:

[0031] 1) raw material processing: breaking fresh mango leaves;

[0032] 2) High-pressure micro-jet ultra-fine pulverization treatment: add equal weight of pure water to the material obtained in the previous step, and then add petroleum sodium sulfonate equivalent to 0.4% of the weight of the material, and process it with a high-speed shear emulsifier for 20 minutes at a speed of 12000r / min, then process it at 25°C with high-pressure micro-jet ultrafine pulverization equipment, the processing pressure is 120MPa, and the number of times of processing is 3 times to obtain a paste slurry;

[0033] 3) Separation: perform two-phase extraction on the obtained creamy slurry to obtain the upper extraction phase and the lower extraction phase. The two-phase aqueous system used in the two-phase extraction is composed of polyethylene glycol, sodium carbonate and water. The poly The mass...

Embodiment 3

[0037] A method for extracting mangiferin from mango leaves, specifically comprising the steps of:

[0038]1) raw material processing: breaking fresh mango leaves;

[0039] 2) High-pressure micro-jet ultra-fine pulverization treatment: add equal weight of pure water to the material obtained in the previous step, and then add petroleum sodium sulfonate equivalent to 0.5% of the weight of the material, and process it with a high-speed shear emulsifier for 15 minutes at a speed of 10000r / min, then process it at 25°C with high-pressure micro-jet ultrafine pulverization equipment, the treatment pressure is 100MPa, and the number of times of treatment is 3 times to obtain a paste slurry;

[0040] 3) Separation: perform two-phase extraction on the obtained paste slurry to obtain the upper extraction phase and the lower extraction phase. The two-phase aqueous system used in the two-phase extraction is composed of polyethylene glycol, sodium carbonate and water. The poly The mass per...

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Abstract

The invention discloses a method for extracting mangiferin from leaves of mangifera indica linn. The method comprises the following steps: raw material treatment, high-pressure microjet superfine grinding treatment, dual-aqueous phase extraction, desalting and recrystallization. The obtained mangiferin is high in content and light in color.

Description

technical field [0001] The invention relates to an extraction method in the field of biotechnology, in particular to a method for extracting mangiferin from mango leaves. Background technique [0002] Mango (Mangifera indica linn) is a fruit tree growing in the tropics and subtropics. It is widely distributed in Hainan, Guangxi, Guangdong and other provinces in my country; Guangxi Zhuang Autonomous Region is one of the main producing areas of mangoes, and it is also a key fruit tree in Guangxi. Dong County and Tianyang County were once named "Hometown of Mango" by the Ministry of Agriculture. [0003] Mango leaf is the leaf of Mango Mangifera indica L, a plant of Anacardiaceae. It is a local traditional Chinese medicine in Guangxi. It is recorded in the 1990 edition of "Guangxi Standards of Traditional Chinese Medicine". Active ingredients, mangiferin has anti-inflammatory, anti-virus, central nervous system suppression and immunosuppressive effects, as well as anti-lipid pe...

Claims

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Application Information

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IPC IPC(8): C07D407/04
CPCC07D407/04
Inventor 邹登峰柯珍陈剑娇陈志强文剑赵理云
Owner GUILIN MEDICAL UNIVERSITY
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