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New method for synthesizing diisocyanate for medical polyurethane

A technology of diisocyanate and isophorone diisocyanate, applied in the field of preparation of diisocyanate, can solve problems such as affecting product applicability, existing safety hazards, difficult separation and recovery, etc., achieving significant economic and social benefits and low production costs , the effect of simple preparation process

Inactive Publication Date: 2019-03-15
关爱丽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are following problems in the production process: (1) phosgene is a highly toxic gas, which has potential safety hazards; (2) the by-product hydrogen chloride causes serious environmental pollution; (3) the equipment is severely corroded; (4) the product contains a small amount of Hydrolysis of chlorine, affecting the applicability of the product
Recently, some companies use the urea method to produce IPDI, and the yield is acceptable. It is a promising non-phosgene method for producing IPDI. It has certain competitiveness in the market, but it has high requirements for equipment and requires relatively high production capacity. High temperature, difficult operation, high boiling point of by-products, difficult to separate and recover

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A homogeneous mixture of 0.3 g Cu / AC catalyst and 1.0 g quartz sand was placed in the center of a stainless steel reaction tube. 0.5ml / min methanol was introduced into the reactor through a micropump, fully heated and vaporized, then mixed with 40ml / min carbon monoxide and 2.5ml / min oxygen, reacted at 150°C and 0.1MPa for 3h, stopped heating, and lowered the temperature. Add 1ml / min isophorone diamine and 0.5ml / min sodium methoxide catalyst into the reactor through a micropump, control the reaction temperature at 60°C, and the pressure is normal pressure, and obtain isophorone by cooling and refluxing during the reaction Ketone diisocyanate.

Embodiment 2

[0016] A homogeneous mixture of 0.3 g Cu / AC catalyst and 0.3 g quartz sand was placed in the center of a stainless steel reaction tube. 0.5ml / min methanol was introduced into the reactor through a micropump, fully heated and vaporized, then mixed with 12.5ml / min carbon monoxide and 1.25ml / min oxygen, reacted at 100°C, 1MPa for 1h, stopped heating, and lowered the temperature. Add 0.25ml / min isophorone diamine and 0.25ml / min sodium methoxide catalyst into the reactor through a micropump, control the reaction temperature at 60°C and the pressure at normal pressure, and obtain isophorone by cooling and refluxing during the reaction ketone diisocyanate.

Embodiment 3

[0018] A homogeneous mixture of 0.5 g of Cu / AC catalyst and 1 g of quartz sand was placed in the center of a stainless steel reaction tube. 1ml / min methanol was introduced into the reactor through a micropump, fully heated and vaporized, then mixed with 100ml / min carbon monoxide and 5ml / min oxygen, reacted at 130°C and 0.5MPa for 2h, stopped heating, and lowered the temperature. Add 1ml / min isophorone diamine and 0.75ml / min sodium methoxide catalyst into the reactor through a micropump, control the reaction temperature at 60°C and the pressure at normal pressure, and obtain isophorone by cooling and refluxing during the reaction Ketone diisocyanate.

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PUM

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Abstract

The invention is a novel method for synthesizing diisocyanate for medical polyurethane. Isophorone diamine is synthesized in one step with a fixed bed reactor by using methanol and isophorone diamineas raw materials. The method obviously shortens the conventional process flow, is simple in operation, mild in condition and high in yield, and has a good application prospect.

Description

technical field [0001] The invention relates to the field of polyurethane, in particular to a method for preparing diisocyanate. Background technique [0002] Due to its excellent mechanical strength, high elasticity, wear resistance, lubricity, fatigue resistance and good biocompatibility, polyurethane is widely used in biomedical fields, such as cardiac pacemaker insulated wires, artificial blood vessels, and interventional catheters Wait. Medical polyurethane is usually composed of a soft segment and a hard segment. The soft segment is polylactic acid, and the hard segment is a degradable non-toxic diisocyanate, and isophorone diisocyanate (IPDI) is one of the most important diisocyanates. At present, more than 85% of IPDI in the world is produced by phosgenation, which has the advantages of short process, high yield and low raw material cost. But there are following problems in the production process: (1) phosgene is a highly toxic gas, which has potential safety hazar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C263/00C07C265/14
CPCC07C263/00C07C2601/14
Inventor 关爱丽邵一兵栾晓娜王晓庆邢聪慧
Owner 关爱丽
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