Preparation method of gymnadenia conopsea wall-broken decoction pieces

A technology of broken wall decoction pieces and palm ginseng, which is applied in the field of medicine, can solve the problems that the microbial content of the product cannot be guaranteed, the sterilization process is cumbersome, and the time cost is high. Effect

Active Publication Date: 2019-03-19
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sterilization process of this method is cumbersome, time-consuming, and time-costly, and after the coarse powder is sterilized, it is easily contaminated by mi...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An embodiment of the preparation method of palm ginseng broken wall decoction pieces of the present invention includes the following steps:

[0028] (1) Steam explosion treatment of medicinal materials: Wash 5kg of fresh palm ginseng medicinal materials with water to clean the impurities on the surface, and place the water on the surface to drain, and then use steam explosion technology to break into palm ginseng coarse slag (the pressure of steam explosion is 1.2MPa, palm ginseng) The water content is 10%, and the time to maintain the pressure is 1.0min);

[0029] (2) Broken wall: The coarse slag is dried under reduced pressure at 45°C for 3 hours to make the moisture reach about 10%. The palm ginseng coarse slag is broken and crushed by a micro-powder under low-temperature circulation conditions. The crushing time is 20 minutes. For ultra-fine powder with 300 meshes or more, routinely check the microbes in the palm ginseng coarse powder until it meets the microbial limit r...

Embodiment 2

[0033] An embodiment of the preparation method of palm ginseng broken wall decoction pieces of the present invention includes the following steps:

[0034] (1) Steam explosion treatment of medicinal materials: 5 kg of fresh palm ginseng medicinal materials are washed with water on the surface of impurities, and the surface water is drained, and then steam blasting technology is used to break into palm ginseng coarse slag (the pressure of steam explosion is 1.8MPa, palm ginseng The water content is 80%, and the pressure is maintained for 10 minutes);

[0035] (2) Breaking the wall: place the crude slag in a freeze-drying box to cool to -35°C, keep it for 3 hours for freeze-drying, evacuate to a system absolute pressure of 50Pa, start heating to 50°C, sublimate and dry for 3 hours, The water content reaches about 5%; the coarse slag of palm ginseng is crushed by a micro-powder machine under low-temperature circulation conditions. The crushing time is 15 minutes. The wall is broken an...

Embodiment 3

[0039] An embodiment of the preparation method of palm ginseng broken wall decoction pieces of the present invention includes the following steps:

[0040] (1) Steam explosion treatment of medicinal materials: 5kg of fresh palm ginseng medicinal materials are washed with water on the surface of impurities, placed to drain the surface water, and then broken into coarse palm ginseng slag by steam explosion technology (the pressure of steam explosion is 1.5MPa, palm ginseng) The water content is 50%, and the time to maintain the pressure is 5min);

[0041] (2) Broken wall: Put the palm ginseng crude residue in a freeze-drying box to cool to -35°C, keep it for 5 hours for freeze-drying, evacuate to a system absolute pressure of 50Pa, start heating to 50°C, sublimate and dry for 3 hours , To make the water content below 5%; the palm ginseng coarse slag is crushed by a micro-powder machine under low-temperature circulation conditions. The crushing time is 20 minutes. The wall is broken a...

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Abstract

The invention relates to a preparation method of gymnadenia conopsea wall-broken decoction pieces and belongs to the technical field of medicines. The preparation method of the gymnadenia conopsea wall-broken decoction pieces comprises the following steps: (1) breaking gymnadenia conopsea into coarse residues through a steam blasting technique; (2) drying the coarse residues and then breaking thecoarse residues into ultramicro powder by using an ultramicro pulverization technique, taking thin-wall cells as indicative characteristic cells to determine wall breakage rate of the ultramicro powder of gymnadenia conopsea to obtain ultramicro powder reaching the standard of the wall breakage rate; and (3) adding a solvent into the ultramicro powder, granulating, drying, neatening granules and packaging to obtain the gymnadenia conopsea wall-broken decoction pieces. The granules of the gymnadenia conopsea wall-broken decoction pieces prepared by the method is good in granule shape, relatively easy to dry, moderate in tightness, high in water solubility, clear in wall breakage rate index, high in wall breakage rate, high in medicine effective component retention rate, high in dissolutionrate and high in medicine utilization rate; the microorganism limit of the prepared products is easily controlled; safety and effectiveness of medicine application can be ensured.

Description

Technical field [0001] The invention relates to a preparation method of palm ginseng broken wall decoction pieces, belonging to the technical field of medicine. Background technique [0002] Palm ginseng (Gymnadeniaconopsea (L.) R.Br.), also known as hand ginseng, palm ginseng, hand ginseng, bergamot, is the tuber of orchid plant hand ginseng or thick-veined hand ginseng. It is a rare species that grows on the Qinghai-Tibet Plateau. The medicinal material grows in alpine bushes at an altitude of 3000 to 4000 meters. It is named because it looks like a palm. It has the effects of nourishing essence, promoting essence and quenching thirst, and is often used in powder form. It is a blindly important drug in Tibetan medicine and a blind medicinal material in many Tibetan medicine formulations, such as the "Bushen Pill" recorded in the National Tibetan Medicine Standards Book ", "Shi Wei Shou Shen San", "Eighteen Flavor Codonopsis Pills" and other Tibetan medicinal compounds are comp...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/16
CPCA61K36/898A61K2236/17A61K2236/15
Inventor 袁诚龙海林蔡鸿飞张懿李康强潘裕清李海波杨阳许文东蒋兆健
Owner GUANGZHOU HANFANG PHARMA
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