Technological preparation method of anti-virus oral liquid

An antiviral oral liquid and preparation technology, applied in the field of traditional Chinese medicine, can solve the problems of complete loss of volatile components, unsatisfactory inclusion effect, low water solubility of volatile oil, etc., to achieve guaranteed curative effect, high encapsulation efficiency, and equipment The effect of less investment

Inactive Publication Date: 2019-03-22
安徽东盛友邦制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Forsythia, patchouli, calamus, and turmeric in the prescription contain volatile oils. According to literature reports, pharmacodynamic experiments have proved that patchouli alcohol (patiole alcohol) in the antiviral oral liquid has good antipyretic, Antibacterial effect, but the current extraction process uses water extraction and alcohol precipitation, and the extracted volatile components are directly added to the oral liquid. Since the volatile oil is less water-soluble and volatile, when the volatile oil is added to the filtrate, it will be used in potting and sealing. The volatile oil will be lost during the sterilization process, and as the storage time prolongs, the volatile components in the finished product will gradually be lost
[0003] Therefore, in order to improve the stability of the product and ensure the effective components of the volatile oil in the product, the cyclodextrin inclusion technology is often used in the prior art to carry out the inclusion treatment of the volatile oil, such as the name "a new process for preparing antiviral oral liquid" Chinese patent CN1939525A, which adopts water-soluble cyclodextrin to carry out inclusion treatment for volatile oil, but uses cyclodextrin to encapsulate volatile oil, and its inclusion rate is 40-85%, and the inclusion effect is not ideal

Method used

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  • Technological preparation method of anti-virus oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method of antiviral oral liquid, concrete process step is as follows:

[0033] (1) Pretreatment of traditional Chinese medicine raw materials: Weigh 900g isatis root, 400g gypsum, 200g patchouli, 225g rehmannia glutinosa, 175g turmeric, 425g reed rhizome, 175g Shichangpu, 175g Anemarrhena anemarrhena, 325g forsythia Below 10mm, mix well and set aside;

[0034] (2) Distillation and extraction: Use steam distillation to distill and extract the above-mentioned mixed medicinal materials after crushing, add 8 times the amount of pure water to the mixed medicinal materials and mix them, and keep a slight boil under the condition of steam pressure 0.05-0.10Mpa after boiling State for 1.5 hours, collect 1964mL of volatile oil emulsion;

[0035] Then add 6 times the amount of purified water to the obtained dregs, boil it and keep it in a slightly boiling state for 1 hour and 20 minutes under the condition of steam pressure of 0.01-0.05Mpa, and filter and combine...

Embodiment 2

[0043] Embodiment 2: preparation method is basically the same as embodiment 1, difference is:

[0044] Step (5) volatile oil clathrate treatment:

[0045]Take 10 g of water-soluble cyclodextrin and add an appropriate amount of distilled water to prepare a saturated solution, then add the volatile oil emulsion collected in step (2), place it in an ultrasonic instrument, and place it at a temperature of 45-52°C for 30-60 minutes;

[0046] After adding a small amount of absolute ethanol solution, place it at a temperature of 45°C, add an appropriate amount of colloidal silica in small amounts for several times, stir and grind while adding, and grind until it becomes a paste, continue grinding for 20-30 minutes, and filter with suction , the resulting clathrate was rinsed with absolute ethanol, dried at 40°C to obtain a powdery volatile oil clathrate, and the mass of the clathrate was weighed.

Embodiment 3

[0047] Embodiment 3: The preparation method is basically the same as in Example 1, the difference is that the volatile oil emulsion obtained in step (2) is directly subjected to inclusion treatment: first, the volatile oil content in the volatile oil emulsion is measured and measured;

[0048] Take 50g of water-soluble cyclodextrin and add an appropriate amount of distilled water to prepare a saturated solution, then add the volatile oil emulsion collected in step (2), place it in an ultrasonic instrument, and place it at 50°C for 30 minutes;

[0049] After adding 40mL of absolute ethanol solution, place it at 45°C, add 15g of colloidal silicon dioxide in small amounts for several times, stir and grind while adding, and grind until it becomes a paste, continue grinding for 30min, and filter with suction. The compound was rinsed with absolute ethanol and dried at 40°C to obtain a powdery volatile oil clathrate, and the mass of the clathrate was weighed.

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Abstract

The invention discloses a technological preparation method of anti-virus oral liquid. The technological preparation method comprises the following steps: pretreating Chinese herbal raw materials, performing distilling extraction to collect a volatile oil emulsion, concentrating the extracting solution, performing alcohol precipitation and concentration, and preparing the liquid, wherein before liquid is prepared, an ultrasonic-gel grinding method is adopted to include the volatile oil emulsion by using colloidal silicon dioxide under the assistance of water-soluble cyclodextrin. Compared withthe inclusion method using the cyclodextrin singly in the prior art, the technological preparation method provided by the invention has the advantages that the encapsulating efficiency is higher and the heating temperature in the inclusion process is relatively low; the volatile oil component is retained to the greatest extent; the equipment investment is small; the technological preparation method is suitable for industrial mass production in an enterprise. The prepared anti-virus oral liquid can obviously improve the stability of the volatile oil, so that the therapeutic effect of a productis ensured.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation process of an antiviral oral liquid. Background technique [0002] Antiviral Oral Liquid is a Chinese patent medicine approved by the Ministry of Health of the People's Republic of China. Composition, one of which is mineral medicine gypsum, and the other eight are herbal medicines. The prescription is 129g isatis root, 57g gypsum, 61g reed rhizome, 32g rehmannia root, 25g turmeric, 25g Anemarrhena, 25g Shichangpu, 29g patchouli, Warm 46g add auxiliary materials, purified water to make 1000ml antiviral oral liquid. It is clinically used for viral infectious diseases such as wind-heat cold, upper respiratory tract infection caused by fever due to febrile disease, influenza and mumps, and has good curative effect. Forsythia, patchouli, calamus, and turmeric in the prescription contain volatile oils. According to literature r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/69A61K47/04A61K36/9066A61P31/12A61K33/06
CPCA61K9/0095A61K33/06A61K36/195A61K36/315A61K36/532A61K36/634A61K36/804A61K36/888A61K36/8964A61K36/899A61K36/9066A61K47/02A61K47/6951A61P31/12A61K2300/00
Inventor 苏悌孙海王娇耿云李方楼
Owner 安徽东盛友邦制药有限公司
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