Probiotic composition for preventing and treating allergic rhinitis, nasal preparation and preparation method based on it

A technology for allergic rhinitis and probiotics, used in allergic diseases, drug combinations, medical preparations with inactive ingredients, etc. question

Active Publication Date: 2021-09-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, allergic rhinitis is an allergic disease mainly manifested by nasal symptoms, and oral administration of probiotics to prevent and treat allergic rhinitis has the following problems: 1. The role of regulating the immune state of the nose is indirect, and It cannot prevent antigenic substances from contacting the nasal mucosa, so it is usually used as adjuvant therapy; 2. Probiotics are generally regarded as safe (GRAS), but long-term oral administration of probiotics can cause hypersensitivity to allergens and gastrointestinal symptoms (such as Diarrhea) and other side effects; 3. When oral probiotics pass through the digestive tract, they are digested by gastric juice and pancreatic juice, so the number of live bacteria that actually play a role will be greatly reduced; 4. Oral probiotics can indirectly treat allergic rhinitis by regulating the immune status of the whole body. Slow to act and does not provide quick relief of nasal symptoms
Although this invention can solve the problem that probiotics are difficult to colonize in the respiratory tract, there are still some deficiencies
For example, because probiotics are afraid of water, the survival time of probiotics in liquid products is very short, and the number of active probiotics will drop sharply; the surface active substances in the lower respiratory tract play a very important role in maintaining the normal function of the human respiratory system. The surfactants added in the drug may disturb the normal concentration of surfactants in the lower respiratory tract, resulting in potential side effects; nasal immersion takes a long time, is cumbersome to use, and the process is not comfortable

Method used

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  • Probiotic composition for preventing and treating allergic rhinitis, nasal preparation and preparation method based on it
  • Probiotic composition for preventing and treating allergic rhinitis, nasal preparation and preparation method based on it
  • Probiotic composition for preventing and treating allergic rhinitis, nasal preparation and preparation method based on it

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] In terms of mass fraction, it includes: 75% medical gel, 8% isomaltooligosaccharide, 1% Sanguobao, and 100% glycerin; The order of magnitude of bacteria is 10 8 ).

[0109] Preparation method:

[0110] (1) Weigh the sterilized medical gel, isomaltooligosaccharide and Sanguobao according to the above ratio, stir at 75°C for 15min, 600-800rpm;

[0111] (2) Inoculate the probiotic powder into the sterilized glycerin, stir at 37°C for 10min, 600rpm;

[0112] (3) After cooling the gel mixture prepared in (1) to 37°C, add the probiotic glycerol mixture prepared in (2), and stir at 37°C for 10 minutes at 600 rpm to obtain the product.

[0113] Note that the Sanguobao used in the embodiment of the present invention is a product that can be purchased on iHerb, and its UPCCode: 797734507287. (The following examples are the same)

Embodiment 2

[0115] In terms of mass fraction, it includes: 75% medical gel, 8% isomaltooligosaccharide, 1% Sanguobao, 100% glycerin; probiotic powder: selected from Lactobacillus acidophilus and Bifidobacterium (acidophilus The mass ratio of Lactobacillus: Bifidobacteria is 3:1, and the order of probiotics contained in each milliliter gel is 10 8 ).

[0116] Preparation method:

[0117] (1) Weigh the sterilized medical gel, isomaltooligosaccharide and Sanguobao according to the above ratio, stir at 75°C for 15min, 600-800rpm;

[0118] (2) Inoculate the probiotic powder into the sterilized glycerin, stir at 37°C for 10min, 600rpm;

[0119] (3) After cooling the gel mixture prepared in (1) to 37°C, add the probiotic glycerol mixture prepared in (2), and stir at 37°C for 10 minutes at 600 rpm to obtain the product.

Embodiment 3

[0121] In terms of mass fraction, it includes: water-soluble chitosan 2%, isomaltooligosaccharide 10%, Sanguobao 1%, NaCl 1%, double distilled water to 100%; probiotic powder: selected from Lactobacillus acidophilus (The order of magnitude of probiotics contained in every milliliter lotion is 10 8 ).

[0122] Preparation method:

[0123] (1) Weigh the sterilized water-soluble chitosan, isomaltooligosaccharide, Sanguobao and NaCl according to the above ratio, stir at 75°C for 15min, 600-800rpm;

[0124] (2) Inoculate the probiotic powder into (1) cooled to 37°C, stir at 37°C for 10min, 600rpm;

[0125] (3) Adjust the pH of (2) to 5.5. If the pH is low, NaOH can be added, and if the pH is high, lactic acid can be added.

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Abstract

The invention discloses a probiotic composition for preventing and treating allergic rhinitis, a nasal preparation and a preparation method based on the probiotic composition. The probiotic is used as an active ingredient and a composite stabilizer is used as a matrix. The nasal gel or ointment of the present invention is applied to the inner wall of the nasal cavity to form a protective film in the nasal cavity, just like wearing an invisible mask, effectively blocking inhaled allergens (such as pollen in the air) from entering the human body through the nasal cavity, Thereby eliminating or alleviating allergic symptoms; at the same time, the probiotic composition contained can more quickly and directly play an immune regulatory role in the nasal mucosa, that is, by promoting the secretion of interleukin 12 (IL‑12) and interferon gamma, Regulate Th1 type immune response and inhibit immunoglobulin IgE, improve the hypersensitivity of Th2 type immune response, and do not produce other side effects at the same time.

Description

technical field [0001] The invention belongs to the technical field of preparations for treating allergic rhinitis, and relates to a probiotic composition for preventing and treating allergic rhinitis, a nasal preparation based thereon and a preparation method. Background technique [0002] The nose is the gateway for human breathing, and it undertakes key physiological functions such as breathing and immune defense. Various nasal inflammations can be caused by genetic variation, environmental pathogenic factors, abnormal clearance function or immune defense function, etc. Epidemiological surveys show that the incidence of rhinitis in my country is as high as 37%, of which allergic rhinitis is about 11.3%, and the number of patients is close to 150 million. It has become one of the persistent diseases affecting people's quality of life. Allergic rhinitis is allergic rhinitis, which refers to the release of mediators (mainly histamine) mediated by IgE after atopic individual...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K36/47A61K36/185A61K9/06A61K47/26A61P11/02A61P37/08
CPCA61K9/0043A61K9/06A61K35/741A61K36/185A61K36/47A61K47/26A61K47/36A61P11/02A61P37/08A61K2300/00
Inventor 王馨佩李嘉陈晓栋杨红燕赵美娜张星
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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