Composite flexible sio for bone repair 2 -Elastic airgel scaffolds of cao fibers

Abstract

The invention provides an elastic aerogel stent with compound flexible SiO2-CaO fibers for bone repair. The stent is characterized by comprising a high molecular aerogel with SiO2-CaO fibers dispersed, wherein the SiO2-CaO fibers are overlapped in the high molecular aerogel in a staggered manner; and high molecules at the overlap of the fibers are crosslinked chemically to fix the fibers. The flexible SiO2-CaO fibers in the aerogel stent are taken as a three-dimensional spatial framework and natural high molecules coating the surfaces of the fibers are taken as a structural anchoring point andan elastic buffer area. The aerogel stent has compressive rebound resilience in a water environment, can achieve close fit of small cut implanting and an irregular bone injury area, can promote mineralization of living bodies, and can load cells, so that the bone injury repairing effect is improved.

Description

technical field [0001] The invention relates to a composite flexible SiO2 for bone repair 2 - The technical field of elastic airgel scaffold of CaO fiber and its preparation method, belonging to the field of biomedical materials. Background technique [0002] According to statistics, about 2 million patients in my country need bone graft repair and bone reconstruction every year due to complications such as bone defect and osteonecrosis. At present, autologous bone transplantation is widely used clinically, which has the advantages of good histocompatibility and low immune rejection, so autologous bone transplantation is still the "gold standard" for clinical treatment of bone defects (Sci.Transl.Med.2016 ,8,343). However, the source of autologous bone is limited, and at the same time it causes new defects, so its clinical application is limited. In recent years, inorganic materials such as bioceramics (alumina ceramics, calcium phosphate, hydroxyapatite), porous metals (...

AI Technical Summary

Problems solved by technology

However, whether it is body bone or inorganic materials, as a hard material, there are the following problems: First, the transplantation of hard materials often requires relatively large surgical incisions, resulting in secondary damage to the soft tissue at the damaged site; second, hard materials are difficult to shape accurately, and the surface It is difficult to maintain a tight fit for irregular bone defects, which affects osseointegration and long-term repair effect

In the field of bone tissue engineering, SiO 2 -CaO series bioactive glasses have good osteoconductivity, can promote the repair of bone damage, and have broad application prospects as bone tissue replacement and repair materials, but SiO 2 -CaO itself is brittle and cannot be used alone for bone tissue repair with certain load-bearing parts

Therefore, the existing patented technology is not suitable for the preparation of SiO 2 -CaO fiber-based bone repair

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