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Terpene pharmaceutical composition self-emulsifying oral preparation as well as preparation method and application

A technology for oral preparations and compositions, which is applied in the field of self-emulsifying oral preparations and preparations of terpene pharmaceutical compositions, can solve problems such as unstable preparation quality, achieve the effects of reducing irritation, ensuring therapeutic effects, and avoiding nausea

Active Publication Date: 2019-03-29
BEIJING GRAND JOHAUM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved by the present invention is to overcome the defect that the preparation quality is not stable in the oral formulations of the pharmaceutical composition containing eucalyptol, limonene and α-pinene prepared by the existing method, thereby providing a terpene drug Composition Self-emulsifying oral formulation

Method used

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  • Terpene pharmaceutical composition self-emulsifying oral preparation as well as preparation method and application
  • Terpene pharmaceutical composition self-emulsifying oral preparation as well as preparation method and application
  • Terpene pharmaceutical composition self-emulsifying oral preparation as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The preparation of embodiment 1 terpene pharmaceutical composition self-emulsifying soft capsule

[0060] The prescription for self-emulsifying liquid medicine is:

[0061]

[0062]

[0063] The preparation method is:

[0064] (1) get eucalyptol, limonene, α-pinene and soybean oil in the recipe quantity, stir 1 hour with the rotating speed of 50rpm at 15 ℃, mix, obtain oil phase;

[0065] (2) get the Tween 80 of recipe quantity, propylene glycol and add in oil phase, 15 ℃ with the rotating speed of 50rpm and stir for 1 hour, mix, form homogeneous self-emulsifying medicinal liquid;

[0066] (3) Weigh gelatin, glycerin, and water to prepare capsule skins in a weight ratio of 1:0.5:1.1;

[0067] (4) The self-emulsifying medicinal liquid obtained in step (2) and the capsule skin obtained in step (3) are pressed on a soft capsule machine in a conventional manner, and set in a shaping machine to set the shape to prepare a terpene pharmaceutical composition self-emulsi...

Embodiment 2

[0068] The preparation of embodiment 2 terpene pharmaceutical composition self-emulsifying soft capsule

[0069] The prescription for self-emulsifying liquid medicine is:

[0070]

[0071] The preparation method is:

[0072] (1) get eucalyptol, limonene, α-pinene and medium chain triglyceride in the recipe quantity, stir 2 hours with the rotating speed of 30rpm at 30 ℃, mix, obtain oil phase;

[0073] (2) get recipe quantity Labrasol, Transcutol and add in oil phase, stir 2 hours at 30 ℃ with the rotating speed of 30rpm, mix, form homogeneous self-emulsifying medicinal liquid;

[0074] (3) Weigh gelatin, glycerin, and water to prepare capsule skins at a weight ratio of 1:0.45:1.1;

[0075] (4) The self-emulsifying medicinal liquid obtained in step (2) and the capsule skin obtained in step (3) are pressed on a soft capsule machine in a conventional manner, and set in a shaping machine to set the shape to prepare a terpene pharmaceutical composition self-emulsifying soft ca...

Embodiment 3

[0076] The preparation of embodiment 3 terpene pharmaceutical composition self-emulsifying soft capsule

[0077] The prescription for self-emulsifying liquid medicine is:

[0078]

[0079] The preparation method is the same as that of Example 2.

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Abstract

The invention relates to the technical field of pharmaceutical preparations and discloses a terpene pharmaceutical composition self-emulsifying oral preparation as well as a preparation method and anapplication. The self-emulsifying oral preparation contains pharmaceutical composition containing eucalyptol, limonene and alpha-pinene in a specific ratio, grease, an emulsifier and a co-emulsifier,the components cooperate with one another, so that the prepared terpene pharmaceutical composition self-emulsifying liquid has stable and homogeneous property, quality stability of the terpene pharmaceutical composition self-emulsifying oral preparation is improved, the pharmaceutical treatment effect is guaranteed, and the preparation is suitable for being popularized and applied in a large clinical area.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, and relates to a self-emulsifying oral preparation of a terpene pharmaceutical composition, a preparation method and an application thereof. Background technique [0002] The pharmaceutical composition containing eucalyptol, limonene and α-pinene can be used for cough relief, anti-inflammatory, expectorant and promoting the excretion of contrast agents in patients with respiratory diseases, and as aerosol inhalers for improving the symptoms caused by rhinitis and sinusitis For example, the prior art discloses a pharmaceutical composition fat emulsion injection containing eucalyptol, limonene and α-pinene and a preparation method thereof, and the weight % composition of the injection comprises eucalyptus Olefin 0.0128-0.032%, limonene 0.0084-0.0210%, α-pinene 0.0028-0.0070%, soybean oil for injection 10-30%, egg yolk lecithin for injection 1.0-1.5% or soybean lecithin for injec...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/44A61K47/24A61K47/14A61K31/35A61K31/015A61P11/00A61P11/02A61P31/06A61P31/10
CPCA61K47/14A61K47/24A61K47/44A61P11/00A61P11/02A61P31/06A61P31/10A61K9/0053A61K9/107A61K31/015A61K31/35A61K2300/00
Inventor 韩悦耿海明沈芳玲赵家欣胡昱代向东霍扬扬
Owner BEIJING GRAND JOHAUM PHARMA CO LTD
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